List of works - Fumio Sakane

1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain

scientific article published on 05 March 2020

A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response.

scientific article published on 14 January 2016

Abnormalities of the serotonergic system in diacylglycerol kinase δ-deficient mouse brain.

scientific article published on 24 February 2018

Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species.

scientific article published on 20 July 2016

Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions

scientific article

Analytical Method for Diacylglycerol Kinase ζ Activity in Cells Using Protein Myristoylation and Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 17 November 2019

Behavioral and pharmacological phenotypes of brain-specific diacylglycerol kinase δ-knockout mice.

scientific article published on 13 July 2016

Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ.

scientific article

Chaperone function of calreticulin when expressed in the endoplasmic reticulum as the membrane-anchored and soluble forms.

scientific article

Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor

scientific article published on 13 November 2019

Chronic administration of myristic acid improves hyperglycaemia in the Nagoya-Shibata-Yasuda mouse model of congenital type 2 diabetes.

scientific article published on 13 July 2017

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase ⬇️

scientific article published on September 26, 1997

Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain

scientific journal article

Combined inhibition/silencing of diacylglycerol kinase α and ζ simultaneously and synergistically enhances interleukin-2 production in T cells and induces cell death of melanoma cells

scientific article published on 05 January 2021

Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids

scientific article published on 19 April 2019

Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains

scientific article published on 04 February 2019

DaMab-2: Anti-Human DGKα Monoclonal Antibody for Immunocytochemistry

scientific article published on 25 July 2017

Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior.

scientific article published on 11 May 2016

Depression of type I diacylglycerol kinases in pancreatic β-cells from male mice results in impaired insulin secretion.

scientific article published on 13 September 2013

Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C.

scientific article

DgMab-6: Antihuman DGKγ Monoclonal Antibody for Immunocytochemistry

scientific article published on 01 November 2018

Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update

scientific article

Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras–Raf–MEK–ERK pathway ⬇️

scientific article published on March 14, 2012

Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation

scientific article

Diacylglycerol kinase and phosphatidic acid phosphatase--enzymes metabolizing lipid second messengers.

scientific article published on September 1993

Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1.

scientific article

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.

scholarly article

Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.

scientific article published on 26 August 2009

Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor.

scientific article published on 18 January 2007

Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling

scientific journal article

Diacylglycerol kinase isozymes from brain and lymphoid tissues

scientific article published on January 1, 1992

Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines

scientific article published on 09 December 2018

Diacylglycerol kinase β induces filopodium formation via its C1, catalytic and carboxy-terminal domains and interacts with the Rac1-GTPase-activating protein, β2-chimaerin

scientific article published on 28 August 2018

Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference

scientific article published on 31 January 2014

Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains

scientific article published on 24 January 2020

Diacylglycerol kinase δ controls down-regulation of cyclin D1 for C2C12 myogenic differentiation.

scientific article

Diacylglycerol kinase δ phosphorylates phosphatidylcholine-specific phospholipase C-dependent, palmitic acid-containing diacylglycerol species in response to high glucose levels.

scientific article

Diacylglycerol kinase δ1 transiently translocates to the plasma membrane in response to high glucose.

scientific article

Diacylglycerol kinase ζ generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation

scientific article published on 15 October 2016

Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol.

scientific article

Diacylglycerol kinase--a novel enzyme having both zinc finger and E-F hand motifs

scientific article published on 01 July 1990

Diacylglycerol kinases: emerging downstream regulators in cell signaling systems.

scientific article

Diacylglycerol kinases: why so many of them?

scientific article published on 14 April 2007

Diacylglycerol kinase‐dependent formation of phosphatidic acid molecular species during interleukin‐2 activation in CTLL‐2 T‐lymphocytes ⬇️

scientific article published on September 4, 2012

Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.

scientific article published on September 2003

Dioleoyl-phosphatidic acid selectively binds to α-synuclein and strongly induces its aggregation.

scientific article

Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes.

scientific article published on 23 June 2016

Distinct expression and localization of diacylglycerol kinase isozymes in rat retina.

scientific article

Distinct expression and localization of the type II diacylglycerol kinase isozymes δ, η and κ in the mouse reproductive organs.

scientific article

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

scientific article published on 01 December 1997

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

scientific article published in February 2008

EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes

scientific article

EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains.

scientific article published on 18 April 2014

Editorial: Diacylglycerol Kinase Signalling.

scientific article published on 21 September 2017

Evaluations of the Selectivities of the Diacylglycerol Kinase Inhibitors R59022 and R59949 Among Diacylglycerol Kinase Isozymes Using a New Non-Radioactive Assay Method ⬇️

scientific article published on August 16, 2013

Expression and localization of type II diacylglycerol kinase isozymes δ and η in the developing mouse brain

scientific article

Expression and purification of human diacylglycerol kinase α from baculovirus-infected insect cells for structural studies

scientific article published on 10 August 2018

Expression, Purification, and Characterization of Human Diacylglycerol Kinase ζ

scientific article published on 19 March 2019

Gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta

scientific article published on 26 April 2005

Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization.

scientific article published on 3 August 2007

Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (type 2) bound to plasma membranes. Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase

scientific journal article

Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa

scientific article

Identification and characterization of two splice variants of human diacylglycerol kinase eta

scientific article

Identification of myosin II as a binding protein to the PH domain of protein kinase B

scientific article published on 01 February 1999

Immunoquantitation of 80 kDa diacylglycerol kinase in pig and human lymphocytes and several other cells.

scientific article published in February 1989

Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase γ independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase γ.

scientific article

Isolation and characterization of the human diacylglycerol kinase gene.

scientific article published on September 1993

Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts

scientific article

Microarray analysis of gene expression in the diacylglycerol kinase η knockout mouse brain

scientific article published on 25 June 2019

Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells

scientific article

Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases

scientific article

Molecules in focus: diacylglycerol kinase.

scientific article

Myristic Acid Enhances Diacylglycerol Kinase δ-Dependent Glucose Uptake in Myotubes.

scientific article published on 20 May 2016

Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells

scientific article published on 11 April 2019

New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein

scientific article published on 16 September 2020

Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus.

scientific article

Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin

scientific article published on 01 January 2008

Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation

scientific article (publication date: 20 September 2002)

Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.

scientific article published in April 1991

Porcine polymorphonuclear leukocyte NADPH-cytochrome c reductase generates superoxide in the presence of cytochrome b559 and phospholipid

scientific article published on 01 August 1987

Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin

scientific article

Purification and characterization of a membrane-bound NADPH-cytochrome c reductase capable of catalyzing menadione-dependent O2- formation in guinea pig polymorphonuclear leukocytes.

scientific article published in September 1984

Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes ⬇️

scientific article published on December 15, 1992

Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv

scientific article published on 12 July 2007

Recent progress on type II diacylglycerol kinases: the physiological functions of diacylglycerol kinase δ, η and κ and their involvement in disease.

scientific article published on 13 September 2012

Regulation of diacylglycerol kinase δ2 expression in C2C12 skeletal muscle cells by free fatty acids.

scientific article

Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1

scientific article

Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells.

scientific article

Screening of subtype-specific activators and inhibitors for diacylglycerol kinase

scientific article published on 01 June 2019

Separation of three menadione-dependent, O2--generating, pyridine nucleotide-oxidizing enzymes in guinea pig polymorphonuclear leukocytes.

scientific article

Stabilizing effect of glutaraldehyde on the respiratory burst NADPH oxidase of guinea pig polymorphonuclear leukocytes.

scientific article published in August 1987

The Pleckstrin Homology Domain of Diacylglycerol Kinase η Strongly and Selectively Binds to Phosphatidylinositol 4,5-Bisphosphate

scientific article published on 17 February 2016

The different effects of sphingosine on diacylglycerol kinase isozymes in Jurkat cells, a human T-cell line.

scientific article published on September 1993

The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain

scientific article

The regulatory role of EF-hand motifs of pig 80K diacylglycerol kinase as assessed using truncation and deletion mutants.

scientific article

Translocation of diacylglycerol kinase α to the nuclear matrix of rat thymocytes and peripheral T-lymphocytes

scientific article published on 01 September 1996

Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways

scientific article

Zinc Binding Drives Sheet Formation by the SAM Domain of Diacylglycerol Kinase δ ⬇️

scientific article published on November 9, 2010

[Diverse structures of diacylglycerol kinase gene family]

scientific article published on 01 March 1997

[The primary structure of diacylglycerol kinase and regulation of its activity]

scientific article published on 01 February 1991

c-Abl Tyrosine Kinase Regulates Serum-induced Nuclear Export of Diacylglycerol Kinase α by Phosphorylation at Tyr-218 ⬇️

scientific article published on December 23, 2011

List of works by Fumio Sakane

1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain

A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response.

Abnormalities of the serotonergic system in diacylglycerol kinase δ-deficient mouse brain.

Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species.

Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions

Analytical Method for Diacylglycerol Kinase ζ Activity in Cells Using Protein Myristoylation and Liquid Chromatography-Tandem Mass Spectrometry

Behavioral and pharmacological phenotypes of brain-specific diacylglycerol kinase δ-knockout mice.

Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ.

Chaperone function of calreticulin when expressed in the endoplasmic reticulum as the membrane-anchored and soluble forms.

Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor

Chronic administration of myristic acid improves hyperglycaemia in the Nagoya-Shibata-Yasuda mouse model of congenital type 2 diabetes.

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase ⬇️

Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain

Combined inhibition/silencing of diacylglycerol kinase α and ζ simultaneously and synergistically enhances interleukin-2 production in T cells and induces cell death of melanoma cells

Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids

Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains

DaMab-2: Anti-Human DGKα Monoclonal Antibody for Immunocytochemistry

Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior.

Depression of type I diacylglycerol kinases in pancreatic β-cells from male mice results in impaired insulin secretion.

Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C.

DgMab-6: Antihuman DGKγ Monoclonal Antibody for Immunocytochemistry

Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update

Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras–Raf–MEK–ERK pathway ⬇️

Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation

Diacylglycerol kinase and phosphatidic acid phosphatase--enzymes metabolizing lipid second messengers.

Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1.

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.

Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.

Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor.

Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling

Diacylglycerol kinase isozymes from brain and lymphoid tissues

Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines

Diacylglycerol kinase β induces filopodium formation via its C1, catalytic and carboxy-terminal domains and interacts with the Rac1-GTPase-activating protein, β2-chimaerin

Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference

Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains

Diacylglycerol kinase δ controls down-regulation of cyclin D1 for C2C12 myogenic differentiation.

Diacylglycerol kinase δ phosphorylates phosphatidylcholine-specific phospholipase C-dependent, palmitic acid-containing diacylglycerol species in response to high glucose levels.

Diacylglycerol kinase δ1 transiently translocates to the plasma membrane in response to high glucose.

Diacylglycerol kinase ζ generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation

Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol.

Diacylglycerol kinase--a novel enzyme having both zinc finger and E-F hand motifs

Diacylglycerol kinases: emerging downstream regulators in cell signaling systems.

Diacylglycerol kinases: why so many of them?

Diacylglycerol kinase‐dependent formation of phosphatidic acid molecular species during interleukin‐2 activation in CTLL‐2 T‐lymphocytes ⬇️

Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.

Dioleoyl-phosphatidic acid selectively binds to α-synuclein and strongly induces its aggregation.

Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes.

Distinct expression and localization of diacylglycerol kinase isozymes in rat retina.

Distinct expression and localization of the type II diacylglycerol kinase isozymes δ, η and κ in the mouse reproductive organs.

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes

EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains.

Editorial: Diacylglycerol Kinase Signalling.

Evaluations of the Selectivities of the Diacylglycerol Kinase Inhibitors R59022 and R59949 Among Diacylglycerol Kinase Isozymes Using a New Non-Radioactive Assay Method ⬇️

Expression and localization of type II diacylglycerol kinase isozymes δ and η in the developing mouse brain

Expression and purification of human diacylglycerol kinase α from baculovirus-infected insect cells for structural studies

Expression, Purification, and Characterization of Human Diacylglycerol Kinase ζ

Gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta

Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization.

Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (type 2) bound to plasma membranes. Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase

Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa

Identification and characterization of two splice variants of human diacylglycerol kinase eta

Identification of myosin II as a binding protein to the PH domain of protein kinase B

Immunoquantitation of 80 kDa diacylglycerol kinase in pig and human lymphocytes and several other cells.

Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase γ independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase γ.

Isolation and characterization of the human diacylglycerol kinase gene.

Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts

Microarray analysis of gene expression in the diacylglycerol kinase η knockout mouse brain

Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells

Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases

Molecules in focus: diacylglycerol kinase.

Myristic Acid Enhances Diacylglycerol Kinase δ-Dependent Glucose Uptake in Myotubes.

Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells

New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein

Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus.

Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin

Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation

Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.