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List of works by Esteban Morcillo

A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.

scientific article published on March 2006

Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways

scientific article published on 04 June 2010

Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition.

scientific article published on 27 September 2012

Aclidinium inhibits human lung fibroblast to myofibroblast transition.

scientific article

Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release.

scientific article published on 23 April 2009

Acute cardio-respiratory effects in rats of PS4alpha, an antineoplastic peptidoglycan from Mycobacterium vaccae

scientific article published on 01 June 2001

Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines

scientific article published on 29 November 2004

Antagonism of leukotriene responses in human airways by BAY x7195

article

Arachidonic acid relaxes human pulmonary arteries through K+ channels and nitric oxide pathways.

scientific article published in October 2004

Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II.

scientific article published in November 2012

Bafetinib inhibits functional responses of human eosinophils in vitro.

scientific article published on 6 June 2013

Binding of [3H][D-Ala2, MePhe4, Gly-ol5] enkephalin, [3H][D-Pen2, D-Pen5]enkephalin, and [3H]U-69,593 to airway and pulmonary tissues of normal and sensitized rats

scientific article published on 01 January 1997

Biotransformation in vitro of the 22R and 22S epimers of budesonide by human liver, bronchus, colonic mucosa and skin.

scientific article

Bronchodilator and anti-inflammatory activities of SCA40: studies in human isolated bronchus, human eosinophils, and in the guinea-pig in vivo

scientific article published on 01 December 1997

CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration

scientific journal article

Calcium dependence of the contraction produced by endothelin (ET-1) in isolated guinea-pig trachea.

scientific article

Changes inα-tocopherol and retinol levels during cardiopulmonary bypass correlate with maximal arterial partial pressure of oxygen

scientific article published on 01 September 2007

Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.

scientific article

Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences

scientific article

Contraction of human airways by oxidative stress protection by N-acetylcysteine

scientific article published on 01 August 1999

Contributions of ACE and mast cell chymase to endogenous angiotensin II generation and leucocyte recruitment in vivo.

scientific article published on 27 May 2011

Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium.

scientific article published on 9 November 2012

Diaphragmatic paralysis following minor cervical trauma

scientific article published on 01 August 2007

Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neurtrophil recruitment in vivo

Effect of sensitization on somatostatin concentration and binding in cytosol from guinea pig airways.

scientific article published in November 1987

Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo.

scientific article published on 14 October 2003

Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte–endothelial cell interactions

Effects of Ca2+ channel antagonists and benzodiazepine receptor ligands in normal and skinned rat urinary bladder

scientific article published on 01 April 1994

Effects of Mn2+ on the responses induced by different spasmogens in the oestrogen-primed rat uterus

article

Effects of Na+ transport inhibitors on guinea-pig tracheal responses to spasmogens

scientific article published on 01 October 1992

Effects of dantrolene on the responses to methylxanthines in the isolated guinea-pig trachea ⬇️

scientific article published on June 6, 1991

Effects of erythromycin on chemoattractant-activated human polymorphonuclear leukocytes

scientific article published on 01 October 1997

Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study

scientific article published on 01 January 1998

Effects of inhaled glaucine on pulmonary responses to antigen in sensitized guinea pigs

scientific article published on 01 May 2000

Effects of ouabain on human bronchial muscle in vitro.

scientific article published on 15 October 2003

Effects of phorbol 12,13-diacetate on human isolated bronchus

scientific article published on 01 June 2000

Electrophysiologic evaluation of phrenic nerve and diaphragm function after coronary bypass surgery: prospective study of diabetes and other risk factors

scientific article published on 01 September 2006

Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression.

scientific article published in January 2005

Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECT in Guinea Pig: Role of Bitter Taste Agonists

scientific article

Evaluation of the quality of publications on randomized clinical trials using the Consolidated Standards of Reporting Trials (CONSORT) statement guidelines in a Spanish tertiary hospital.

scientific article

Extracellular calcium-sensing receptor mediates human bronchial epithelial wound repair.

scientific article published on 8 April 2010

H-7, a protein kinase C inhibitor, inhibits spontaneous tone and spasmogenic responses in normal and sensitized guinea pig trachea

scientific article published on 01 December 1995

Haemodynamic effects of long-term administration of sildenafil in normotensive pregnant and non-pregnant rats.

scientific article published on 18 January 2011

Hawthorn extract inhibits human isolated neutrophil functions.

scientific article published on 8 May 2008

Histamine up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils.

scientific article

In vitro tracheal hyperresponsiveness to muscarinic receptor stimulation by carbachol in a rat model of bleomycin-induced pulmonary fibrosis

scientific article published on 01 July 2006

Increased lung neutrophil apoptosis and inflammation resolution in nonresponding pneumonia

scientific article published on 24 March 2011

Inhibitory effects of N-acetylcysteine on the functional responses of human eosinophils in vitro

scientific article published on 01 May 2007

Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

scientific article

JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study.

scientific article published on 10 February 2018

MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps

scientific article published on 14 September 2016

Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.

scientific article

Modification by indomethacin of airway contractile responses in normal and sensitized guinea-pigs

scientific article published on 01 March 1989

Modulatory effects of N-acetyl-L-cysteine on human eosinophil apoptosis

scientific article published on 15 May 2007

Mucin 1 deficiency mediates corticosteroid insensitivity in asthma

scientific article published on 02 October 2018

Mucus and MUC in asthma

scientific article

Myocardial prostaglandin E release by nitroglycerin and modification by indomethacin.

scientific article published in January 1980

N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV).

scientific article published on 25 May 2011

Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells.

scientific article published in January 2010

Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients.

scientific article published on 8 November 2016

Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen.

scientific article published in March 2003

Oxidative stress and pulmonary inflammation: pharmacological intervention with antioxidants.

scientific article

Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages

scientific article published on 01 April 2011

P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetyl-L-cysteine.

scientific article published on July 2002

Palliative treatment of dyspnea with epidural methadone in advanced emphysema.

scientific article published on November 2005

Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro.

scientific article published in August 1997

Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium

scientific article published on 01 October 1999

Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.

scientific article

Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H(2)O(2) via mechanisms involving AP-1 activation.

scientific article

Relaxation by beta 3-adrenoceptor agonists of the isolated human internal anal sphincter.

scientific article published on 20 January 2010

Relaxation of the isolated human internal anal sphincter by sildenafil

scientific article published on 01 July 2007

Responses to histamine and selective H2-receptor agonists in lung parenchymal strips from normal and sensitized guinea-pigs

scientific article published on 01 August 1989

Responsiveness to tyramine in isolated lung parenchymal strip of guinea-pig and rat.

scientific article published in January 1984

Retinoid X receptor agonists impair arterial mononuclear cell recruitment through peroxisome proliferator-activated receptor-γ activation.

scientific article

Roflumilast Prevents the Metabolic Effects of Bleomycin-Induced Fibrosis in a Murine Model

scientific article

Roflumilast improves corticosteroid resistance COPD bronchial epithelial cells stimulated with toll like receptor 3 agonist

scientific article

Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability.

scientific article

Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury

scientific article published on February 2009

Role of endothelium in the responses to noradrenaline in normal and sensitized guinea-pig aorta

scientific article published on 01 April 1993

Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences.

scientific article published on 13 February 2017

Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis.

scientific article published on 12 March 2009

Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.

scientific article

Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia.

scientific article published on 21 September 2005

Taurine chloramine inhibits functional responses of human eosinophils in vitro.

scientific article published on 13 February 2009

The JAK2 pathway is activated in idiopathic pulmonary fibrosis.

scientific article

The human near-term myometrial beta 3-adrenoceptor but not the beta 2-adrenoceptor is resistant to desensitisation after sustained agonist stimulation.

scientific article

The spasmogenic effect of caffeine in trachealis isolated from control and actively sensitized guinea-pigs

scientific article published on 01 December 1988

The spasmogenic effects of vanadate in human isolated bronchus ⬇️

scientific article published on August 1, 1997

Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.

scientific article published on 13 August 2010

Vascular effects of sildenafil in patients with pulmonary fibrosis and pulmonary hypertension: an ex vivo/in vitro study.

scientific article published on 23 March 2016

Vascular effects of the new anti-migraine agent almotriptan on human cranial and peripheral arteries.

scientific article published in October 2001

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