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List of works by Tsutomu Nakamura

15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways ⬇️

scientific article published on June 12, 2011

Antiemetic efficacy and safety of granisetron or palonosetron alone and in combination with a corticosteroid for ABVD therapy-induced nausea and vomiting

scientific article published on 9 January 2018

Antipsychotics-associated serious adverse events in children: an analysis of the FAERS database.

scientific article published on 5 January 2015

Association of VEGF genotype with mRNA level in colorectal adenocarcinomas

scientific article published on 01 December 2004

Association of cumulative cyclosporine dose with its irreversible nephrotoxicity in Japanese patients with pediatric-onset autoimmune diseases

scientific article published on 01 December 2007

Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.

scientific article published on August 2010

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

scientific article published on 24 October 2016

Circadian variability of pharmacokinetics of 5-fluorouracil and CLOCK T3111C genetic polymorphism in patients with esophageal carcinoma.

scientific article published in June 2005

Comparison between Antiemetic Effects of Palonosetron and Granisetron on Chemotherapy-Induced Nausea and Vomiting in Japanese Patients Treated with R-CHOP.

scientific article published in January 2017

Comparison of antiemetic effects of granisetron and palonosetron in patients receiving bendamustine-based chemotherapy

scientific article published on 01 May 2018

Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma.

scientific article

EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients.

scientific article published on 22 September 2005

Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia

scientific article published on 01 October 2010

Effect of dexamethasone on extracellular secretion of cystatin C in cancer cell lines

scientific article published on 15 October 2012

Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs.

scientific article published in June 2005

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.

scientific article published in April 2002

Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles.

scientific article published on 7 April 2009

Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs.

scientific article published in January 2002

Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.

scientific article

Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport.

scientific article published on January 2006

Effects of arbekacin and vancomycin on release of lactate dehydrogenase and fragmentation of DNA in LLC-PK1 kidney epithelial cells

scientific article published on 01 July 1999

Effects of carvedilol on MDR1 ‐mediated multidrug resistance: comparison with verapamil ⬇️

scientific article published on January 1, 2003

Effects of fosfomycin and imipenem-cilastatin on the nephrotoxicity of vancomycin and cisplatin in rats

scientific article

Effects of fosfomycin and imipenem/cilastatin on nephrotoxicity and renal excretion of vancomycin in rats

scientific article published on 01 May 1998

Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma

scientific article

Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects

scientific article published on 01 October 2002

Effects of reactive oxygen species on cell proliferation and death in HeLa cells and its MDR1-overexpressing derivative cell line.

scientific article published on February 2003

Factors influencing the prediction of steady state concentrations of digoxin.

scientific article published in April 2001

Favorable genetic polymorphisms predictive of clinical outcome of chemoradiotherapy for stage II/III esophageal squamous cell carcinoma in Japanese

scientific article published on 01 June 2007

Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.

scientific article

Genetic polymorphisms in SLC23A2 as predictive biomarkers of severe acute toxicities after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.

scientific article published on 07 February 2014

Genotype-dependent down-regulation of gene expression and function of MDR1 in human peripheral blood mononuclear cells under acute inflammation.

scientific article

IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation.

scientific article published in August 2007

In-vivo clearance study of vancomycin in rats

scientific article published on 01 November 1996

Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers

scientific article

Intradermal concentration of hydroquinone after application of hydroquinone ointments is higher than its cytotoxic concentration.

scientific article published in September 2003

L-type voltage-dependent calcium channel is involved in the snake venom group IA secretory phospholipase A2-induced neuronal apoptosis ⬇️

scientific article published on January 29, 2013

MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese

scientific article published on 01 February 2006

MDR1 T-129C polymorphism can be predictive of differentiation, and thereby prognosis of colorectal adenocarcinomas in Japanese.

scientific article published on July 2006

MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects

scientific article published on 01 April 2003

MDR1 genotype-related pharmacokinetics and pharmacodynamics.

scientific article

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

scientific article published on 01 October 2001

MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer

scientific article published on 01 April 2006

MDR1 up-regulated by apoptotic stimuli suppresses apoptotic signaling

scientific article published on 01 September 2002

MDR1, MRP1 and MRP2 genotypes and in vitro chemosensitivity in Japanese patients with colorectal adenocarcinomas.

scientific article published in January 2004

Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.

scientific article published in January 2004

Pharmacogenetics of intestinal absorption.

scientific article published on July 2008

Prediction of systemic exposure to cyclosporine in Japanese pediatric patients

scientific article published on 14 September 2006

Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma

scientific article

Renal excretion of vancomycin in rats with acute renal failure

scientific article published on 01 February 1997

Reversal effects of Ca2+ antagonists on multidrug resistance via down-regulation of MDR1 mRNA.

scientific article published in January 2007

Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients.

scientific article

Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin

scientific article published on 01 October 2002

Simultaneous determination of single nucleotide polymorphisms of MDR1 genes by electrochemical DNA chip.

scientific article published on June 2005

Simvastatin and lovastatin, but not pravastatin, interact with MDR1.

scientific article published on March 2002

TNF-α -857C>T genotype is predictive of clinical response after treatment with definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma

scientific article published on 15 October 2013

Three-dimensional, but not two-dimensional, culture results in tumor growth enhancement after exposure to anticancer drugs.

scientific article

Transport of Azithromycin into Extravascular Space in Rats

scientific article published on 6 September 2016

VEGF -634C/G Genotype is Predictive of Long-term Survival after Treatment with a Definitive 5-Fluorouracil/cisplatin-based Chemoradiotherapy in Japanese Patients with Esophageal Squamous Cell Carcinoma ⬇️

scientific article published on January 1, 2012

VEGF G-1154A is predictive of severe acute toxicities during chemoradiotherapy for esophageal squamous cell carcinoma in Japanese patients.

scientific article published in August 2008

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