List of works - James Burchfield

A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systems

scientific article

Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta

scientific article published on 24 February 2004

An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction.

scientific article published on 29 June 2017

Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis

scientific article published on 24 December 2019

Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane

scientific article

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

scientific article published on 9 July 2014

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

scientific journal article

Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle

scientific journal article

Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway

scientific article

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.

scientific article published on 7 October 2009

Exocytotic vesicle behaviour assessed by total internal reflection fluorescence microscopy

scientific article published on 12 January 2010

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.

scientific article

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

scientific article published on 02 December 2019

Glucose Transport: Methods for Interrogating GLUT4 Trafficking in Adipocytes.

scientific article published in January 2018

Glucose homeostasis in mice is transglutaminase 2 independent

scientific article

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

scientific article published on 13 February 2018

Identification of a distal GLUT4 trafficking event controlled by actin polymerization

scientific article

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

scientific article published in October 2007

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

scientific article

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes

scientific article published on 19 November 2019

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

scientific article published on 29 March 2018

Multiplexed Temporal Quantification of the Exercise-regulated Plasma Peptidome

scientific article published on 5 October 2017

Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response.

scientific article published on 18 January 2013

Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry

scientific article published on 05 August 2019

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

scientific article

Quantitative proteomic analysis of the adipocyte plasma membrane.

scientific article published on 18 October 2011

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

scientific article published on 11 September 2020

Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes

scientific article published on 22 September 2019

Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction

scientific article published on 02 April 2014

The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes

scientific article

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin

scientific article published on 29 December 2016

The diverse roles of protein kinase C in pancreatic beta-cell function.

scientific article

The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.

scientific article

Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes

scientific article published in October 2009

List of works by James Burchfield

A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systems

Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta

An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction.

Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis

Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle

Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.

Exocytotic vesicle behaviour assessed by total internal reflection fluorescence microscopy

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

Glucose Transport: Methods for Interrogating GLUT4 Trafficking in Adipocytes.

Glucose homeostasis in mice is transglutaminase 2 independent

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Identification of a distal GLUT4 trafficking event controlled by actin polymerization

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

Multiplexed Temporal Quantification of the Exercise-regulated Plasma Peptidome

Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response.

Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

Quantitative proteomic analysis of the adipocyte plasma membrane.

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes

Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction

The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin

The diverse roles of protein kinase C in pancreatic beta-cell function.

The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.

Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes