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List of works by Lucia Altucci

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

scientific article

1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells

scientific article published on 08 July 2014

A DNA methyltransferase modulator inspired by peyssonenyne natural product structures.

scientific article

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

scientific article

A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome

scientific article published on June 2004

A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up

scientific article published on 7 October 2009

ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias

scientific article

Acute myeloid leukemia: therapeutic impact of epigenetic drugs

scientific article

Altered folate receptor 2 expression in uraemic patients on haemodialysis: implications for folate resistance.

scientific article

Analysis of chromatin-nuclear receptor interactions by laser-chromatin immunoprecipitation

scientific article

Anticancer activities of anthocyanin extract from genotyped Solanum tuberosum L. “Vitelotte”

Antioxidant, antimicrobial and anti-proliferative activities of Solanum tuberosum L. var. Vitelotte

scientific article published on 11 January 2013

Antiproliferative, antibacterial and antifungal activity of the lichen Xanthoria parietina and its secondary metabolite parietin

scientific article

Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1

scientific article published in 2021

Author Correction: Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells

scientific article published on 17 April 2020

BK Virus Infection and BK-Virus-Associated Nephropathy in Renal Transplant Recipients

scientific article published on 21 July 2022

BLUEPRINT to decode the epigenetic signature written in blood.

scientific article

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition

scientific article published on 18 April 2019

Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells

scientific article published on 7 September 2012

Biological interactions of biocompatible and water-dispersed MoS nanosheets with bacteria and human cells

scientific article published in Scientific Reports

Bispyridinium dienes: histone deacetylase inhibitors with selective activities

scientific article published on 21 April 2007

Cancer epigenetics: Moving forward.

scientific article published on 7 June 2018

Cancer therapy: New drugs are emerging based on molecular targeting but still many challenges

scientific article published on 25 March 2007

Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement

scientific article published in September 2010

Carbamate prodrug concept for hydroxamate HDAC inhibitors

scientific article

Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications

scientific article published on 28 November 2013

Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway

scientific article published on 05 March 2019

Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies

scientific article published on November 2012

Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues

scientific article published in February 2010

Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia

scientific article

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides

scientific article published in May 2005

Comparative Phytochemical Characterization, Genetic Profile, and Antiproliferative Activity of Polyphenol-Rich Extracts from Pigmented Tubers of Different Solanum tuberosum Varieties

scientific article published on 06 January 2020

Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells

scientific article published on August 2006

Competitive or noncompetitive, that's the question: research toward histone deacetylase inhibitors

scientific article published on May 2008

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.

scientific article published on 24 February 2014

Corrigendum to "SIRT1 inhibition affects angiogenic properties of human MSCs".

scientific article published on 25 March 2015

Cytotoxic Potential of the Marine Diatom Thalassiosira rotula: Insights into Bioactivity of 24-Methylene Cholesterol

scientific article published in 2022

D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts

scientific article published on 28 October 2015

DNA Mutations via Chern-Simons Currents

DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment

scientific article published on 28 December 2019

Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008

article

Decryption of the retinoid death code in leukemia

scientific article

Deregulation of Cell Death in Cancer: Recent Highlights

scientific article published on 26 November 2020

Design of selective nuclear receptor modulators: RAR and RXR as a case study

scientific article published on October 2007

Design, Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

scientific article published on 24 May 2012

Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents

scientific article

Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death.

scientific article published on 29 December 2017

Developing novel non-hydroxamate histone deacetylase inhibitors: the chelidamic warhead

Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells

scientific article published on 12 December 2012

Distinct signaling pathways mediate stimulation of cell cycle progression and prevention of apoptotic cell death by estrogen in rat pituitary tumor PR1 cells

scientific article

ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia

scientific article

Effect of bisphenol A with or without enzyme treatment on the proliferation and viability of MCF-7 cells.

scientific article

Endocannabinoid control of sperm motility: The role of epididymus

scientific article published on 12 February 2007

Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer

scientific article published on 12 November 2019

Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead

scientific article published on 22 August 2008

Epigenetic drugs against cancer: an evolving landscape

scientific article

Epigenetic modulator UVI5008 inhibits MRSA by interfering with bacterial gyrase

scientific article published in Scientific Reports

Epigenetic multiple modulators

scientific article

Epigenetic profiling of the antitumor natural product psammaplin A and its analogues

scientific article published on 15 December 2010

Epigenetic therapies in haematological malignancies: searching for true targets

scientific article published on 05 April 2009

Epigenetic-based therapy: From single- to multi-target approaches

scientific article

Estrogen induces early and timed activation of cyclin-dependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus

scientific article published on 01 March 1997

Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cycli

scientific article published on August 2004

Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies.

scientific article

Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model

scientific article

Extracellular Vesicle-Based Nucleic Acid Delivery: Current Advances and Future Perspectives in Cancer Therapeutic Strategies

scientific article published on 16 October 2020

Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities

scientific article published on 25 May 2007

Functions, aberrations, and advances for chromatin modulation in cancer

scientific article published on January 2014

Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia

scientific article published on 30 May 2015

Genista sessilifolia DC. extracts induce apoptosis across a range of cancer cell lines.

scientific article

Glycation of Wild-Type Apomyoglobin Induces Formation of Highly Cytotoxic Oligomeric Species

scientific article published on November 2015

Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.

scientific article

HDAC inhibitors as epigenetic regulators for cancer immunotherapy

scientific article published on 10 March 2018

HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b.

scientific article

HDAC modulation and cell death in the clinic

scientific article published on 03 February 2012

HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2.

scientific article

HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

scholarly article

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation

scientific article published on 16 July 2010

Histone Deacetylase Inhibitors: Recent Insights from Basic to Clinical Knowledge & Patenting of Anti-Cancer Actions ⬇️

scientific article published on January 1, 2011

Histone acetyltransferase inhibitors and preclinical studies

scientific article published on June 2009

Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation.

scientific article published on 5 October 2009

Histone deacetylase inhibitors promote apoptosis and senescence in human mesenchymal stem cells

scientific article published in May 2009

Histone deacetylase inhibitors: a patent review (2009 - 2011).

scientific article published on 25 October 2012

Histone deacetylase inhibitors: clinical implications for hematological malignancies

scientific article

Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

scientific article published on 30 December 2008

Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells

scientific article published on March 2014

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

scientific article

Identification of Two New Synthetic Histone Deacetylase Inhibitors That Modulate Globin Gene Expression in Erythroid Cells from Healthy Donors and Patients with Thalassemia

article

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

scientific article published on 11 April 2008

Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors

scientific article published on May 2010

Impact of histone deacetylase inhibitors SAHA and MS-275 on DNA repair pathways in human mesenchymal stem cells

scientific article published in November 2010

Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities

scientific article

Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer

scientific article published on 16 December 2019

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

scientific article published on 26 December 2004

Laccase treatment impairs bisphenol A-induced cancer cell proliferation affecting estrogen receptor alpha-dependent rapid signals

scientific article

Leukemia: beneficial actions of retinoids and rexinoids

scientific article published on February 2004

Low 17beta-estradiol levels in CNR1 knock-out mice affect spermatid chromatin remodeling by interfering with chromatin reorganization

scientific article published on 20 June 2013

Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy

scientific article published on 31 December 2020

MePR: a novel human mesenchymal progenitor model with characteristics of pluripotency.

scientific article published on 24 May 2013

Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma

scientific article published in 2022

MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance

scientific article published on 30 December 2020

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).

scientific article published on 14 January 2011

Molecular Docking Simulations on Histone Deacetylases (HDAC)-1 and -2 to Investigate the Flavone Binding

scientific article published on 04 December 2020

Molecular Pathways: The Complexity of the Epigenome in Cancer and Recent Clinical Advances

scientific article published on 17 August 2012

Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells

scientific article published on 18 June 2009

Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability

scientific article published on 22 May 2008

Molecular identification of ERalpha-positive breast cancer cells by the expression profile of an intrinsic set of estrogen regulated genes

scientific article published on September 2004

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Molecular networks in Network Medicine: Development and applications

scientific article published on 19 April 2020

Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells

scientific article published in March 2005

Natural compounds in epigenetics: a current view.

scientific article

New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators

scientific article published on September 2010

New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations

scientific article published on 12 September 2008

New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity

scientific article published on 30 January 2012

Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group

scientific article published on 29 September 2009

Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.

scientific article published on 8 July 2014

Novel benzofuran–chromone and –coumarin derivatives: synthesis and biological activity in K562 human leukemia cells

article published in 2013

Novel cinnamyl hydroxyamides and 2-aminoanilides as histone deacetylase inhibitors: apoptotic induction and cytodifferentiation activity

scientific article published on 4 March 2011

Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity

scientific article published on 4 April 2007

Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities

scientific article published on 22 March 2008

Nuclear size as estrogen-responsive chromatin quality parameter of mouse spermatozoa

scientific article published on 21 August 2013

Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

scientific article

Outer Membrane Vesicles Derived from <i>Klebsiella pneumoniae</i> Influence the miRNA Expression Profile in Human Bronchial Epithelial BEAS-2B Cells

scientific article published on 13 December 2020

PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

scientific article

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

scientific article

Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma

scientific article published on October 2006

Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells.

scientific article published on 11 April 2018

Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells

scientific article published on 08 July 2020

Psidium guajava L. anti-neoplastic effects: induction of apoptosis and cell differentiation.

scientific article

Pyrrole-based hydroxamates and 2-aminoanilides: histone deacetylase inhibition and cellular activities

scientific article

Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells

scientific article published on 06 February 2014

RAR and RXR modulation in cancer and metabolic disease

scientific article published on October 2007

RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer.

scientific article published on 13 March 2018

Recent insights into Histone Acetyltransferase-1: biological function and involvement in pathogenesis

scientific article published on 04 October 2020

Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells

scientific article published on 4 September 2008

Regulation of nuclear receptor and cofactor expression in breast cancer cell lines

scientific article published on April 2003

Relationship between genome and epigenome--challenges and requirements for future research

scientific article published on 18 June 2014

Retinoids and TRAIL: two cooperating actors to fight against cancer

scientific article published on January 2004

Retinoids: potential in cancer prevention and therapy.

scientific article

Retracted: Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients' Outcome

retracted article

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

scientific article

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

scientific article

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes ⬇️

scientific article

Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile

scientific article published on 19 January 2011

Sirtuins and Disease: The Road Ahead ⬇️

scientific article published on January 31, 2012

Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties

scientific article published on November 2006

Specific activity of class II histone deacetylases in human breast cancer cells

scientific article

Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

scientific article published on 27 March 2017

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors

scientific article

Synthesis and Biological Properties of Novel, Uracil-Containing Histone Deacetylase Inhibitors

scientific article published on 01 October 2006

Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues

scientific article published in June 2010

Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors

scientific article published on July 2007

Synthesis of 7-alkylidene-7,12-dihydroindolo[3,2-d]benzazepine-6-(5H)-ones (7-alkylidene-paullones) by N-cyclization–oxidative Heck cascade and characterization as sirtuin modulators

scientific article published on 01 March 2015

Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities

scientific article published in September 2008

Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line

scientific article published on 30 January 2013

TNF-related apoptosis-inducing ligand: signalling of a 'smart' molecule.

scientific article published on 28 December 2007

Targeting Histone Deacetylases in Diseases: Where Are We?

scientific article published on 6 March 2014

Targeting epigenetic networks with polypharmacology: a new avenue to tackle cancer

scientific article published on December 2010

The Cannabinoid Receptor CB1 Stabilizes Sperm Chromatin Condensation Status During Epididymal Transit by Promoting Disulphide Bond Formation

scientific article published on 28 April 2020

The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia.

scientific article published on 22 February 2018

The Jumonji family: past, present and future of histone demethylases in cancer

scientific article

The Ubiquitin Proteasome System in Hematological Malignancies: New Insight into Its Functional Role and Therapeutic Options

scientific article published on 14 July 2020

The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion

scientific article published on 01 July 2000

The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells.

scientific article published on August 2012

Time for Epigenetics

scientific article published on 21 September 2008

Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses.

scientific article published on 15 September 2017

Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B

article

Trials with ‘epigenetic’ drugs: An update ⬇️

scientific article published on October 6, 2012

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

scientific article published on 26 December 2004

Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence

scientific article published on 16 January 2020

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.

scientific article published on 30 January 2012

Up-regulation of miR-146b and Down-regulation of miR-200b Contribute to the Cytotoxic Effect of Histone Deacetylase Inhibitors onras-Transformed Thyroid Cells

scientific article published on 29 March 2013

Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells

scientific article published on 11 July 2013

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

scientific article

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.

scientific article published on 20 February 2017

miRNA-mediated deregulation in leukemia ⬇️

scientific article published on November 15, 2012

on anti-FGFR to fight cancer resistance

scholarly article by Rosaria Benedetti & Lucia Altucci published February 2019 in EMBO Molecular Medicine

tert-Butylcarbamate-containing histone deacetylase inhibitors: apoptosis induction, cytodifferentiation, and antiproliferative activities in cancer cells

scientific article published on 25 March 2013

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