List of works - Amaury Farce

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

scientific article published on 12 May 2009

A computational view of COX-2 inhibition

scientific article

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression

scientific article published on 10 June 2017

Antioxidant Activity of New Benzo[de]quinolines and Lactams: 2DQuantitative Structure-Activity Relationships

scientific article published on 01 September 2012

Derivatives of Iressa, a specific epidermal growth factor receptor inhibitor, are powerful apoptosis inducers in PC3 prostatic cancer cells

scientific article published on March 2007

Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3

scientific article published on 15 February 2011

Differences in Binding Sites of Two Melatonin Receptors Help to Explain Their Selectivity to Some Melatonin Analogs: A Molecular Modeling Study

scientific article published on 01 October 2006

Discovery of ferrocene-containing farnesyltransferase inhibitors. Investigation of bulky lipophilic groups for the A2 binding site of farnesyltransferase

Docking study of ligands into the colchicine binding site of tubulin.

scientific article published on December 2004

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

scientific article published on 5 May 2015

Effect of oxime ether incorporation in acyl indole derivatives on PPAR subtype selectivity

scientific article

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population

scientific article published on 27 July 2011

Homology Modeling of 5-HT2C Receptors

Homology modeling of MT1 and MT2 receptors

scientific article published on 14 December 2007

Homology modelling of the serotoninergic 5-HT2c receptor.

scientific article

Identification of a pharmacophore of SKCa channel blockers

scientific article published in December 2005

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

scientific article

Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings.

scientific article published on 26 September 2016

Molecular modelling of phthalates – PPARs interactions

scientific article published in January 2008

NMR studies of interactions of new CB2 cannabinoid receptor ligands with cyclodextrins hosts. Correlation with micellar electrokinetic chromatography and reversed phase high performance liquid chromatography

New farnesyltransferase inhibitors in the phenothiazine series.

scientific article

New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation

scientific article

Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists

scientific article published on 02 August 2006

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

scientific article published in January 2006

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase

scientific article published on 22 October 2014

Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model

scientific article published on 12 August 2010

On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives

scientific article

On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during Wittig reaction attempts

scholarly article in RSC Advances, vol. 3 no. 11, 2013

Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase

scientific article

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.

scientific article

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

scientific article published on 7 February 2011

Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives.

scientific article

Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer.

scientific article published on April 2010

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations

scientific article

Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.

scientific article

Structural insight into PPARgamma ligands binding.

scientific article published on January 2009

Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds.

scientific article

Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.

scientific article published on April 2016

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

scientific article published on 12 February 2014

Synthesis and Radioligand Binding Studies of Bis-isoquinolinium Derivatives as Small Conductance Ca2+-Activated K+Channel Blockers

scientific article published on 15 September 2007

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents

scientific article

Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors.

scientific article

Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors

scientific article published on 14 November 2012

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands.

scientific article

Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin

scientific article published on 4 April 2013

Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors.

scientific article

Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit.

scientific article published on 10 November 2015

Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

scientific article published on 25 January 2012

Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives.

scientific article published on 17 September 2010

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

scientific article published on 27 February 2012

Three-Dimensional Quantitative Structure–Activity Relationship ofMT3 Melatonin Binding Site Ligands: A Comparative Molecular Field Analysis

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

scientific article published on 8 May 2018

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.

scientific article

List of works by Amaury Farce

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

A computational view of COX-2 inhibition

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression

Antioxidant Activity of New Benzo[de]quinolines and Lactams: 2DQuantitative Structure-Activity Relationships

Derivatives of Iressa, a specific epidermal growth factor receptor inhibitor, are powerful apoptosis inducers in PC3 prostatic cancer cells

Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3

Differences in Binding Sites of Two Melatonin Receptors Help to Explain Their Selectivity to Some Melatonin Analogs: A Molecular Modeling Study

Discovery of ferrocene-containing farnesyltransferase inhibitors. Investigation of bulky lipophilic groups for the A2 binding site of farnesyltransferase

Docking study of ligands into the colchicine binding site of tubulin.

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

Effect of oxime ether incorporation in acyl indole derivatives on PPAR subtype selectivity

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population

Homology Modeling of 5-HT2C Receptors

Homology modeling of MT1 and MT2 receptors

Homology modelling of the serotoninergic 5-HT2c receptor.

Identification of a pharmacophore of SKCa channel blockers

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings.

Molecular modelling of phthalates – PPARs interactions

NMR studies of interactions of new CB2 cannabinoid receptor ligands with cyclodextrins hosts. Correlation with micellar electrokinetic chromatography and reversed phase high performance liquid chromatography

New farnesyltransferase inhibitors in the phenothiazine series.

New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation

Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists

Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase

Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model

On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives

On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during Wittig reaction attempts

Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.

Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.

Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives.

Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer.

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations

Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.

Structural insight into PPARgamma ligands binding.

Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds.

Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

Synthesis and Radioligand Binding Studies of Bis-isoquinolinium Derivatives as Small Conductance Ca2+-Activated K+Channel Blockers

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents

Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors.

Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands.

Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin

Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors.

Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit.

Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives.

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

Three-Dimensional Quantitative Structure–Activity Relationship ofMT3 Melatonin Binding Site Ligands: A Comparative Molecular Field Analysis

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.

[4-(6,7-Disubstituted quinazolin-4-ylamino)phenyl] carbamic acid esters: a novel series of dual EGFR/VEGFR-2 tyrosine kinase inhibitors