List of works - Richard Possemato

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

scientific article

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

scientific article

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

scientific article published on 2 October 2017

Amino acid management in cancer

scientific article

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

scientific article

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

scientific article published on 25 June 2018

Autoregulatory control of mitochondrial glutathione homeostasis

scientific article published on 02 November 2023

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

scientific article

Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

scientific article published on 09 July 2020

Flp recombinase regulated lacZ expression at the ROSA26 locus

scientific article published on 01 February 2002

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

scientific article

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition

scientific article published on 26 November 2024

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.

scientific article

Identification of specific PP2A complexes involved in human cell transformation

scientific article

KRAS4A directly regulates hexokinase 1

scientific article published on 11 December 2019

Leveraging the iron-starvation response to promote ferroptosis

scientific article published on 3 February 2018

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

scientific article

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

scientific article

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

scientific article published on 22 November 2017

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts

scientific article

Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

scientific article published on 01 October 2018

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

scientific article

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

scientific article published in February 2018

Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

scientific article published on 10 October 2017

Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics

scientific article

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

scientific article

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson ⬇️

scientific article published on July 6, 2012

List of works by Richard Possemato

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Amino acid management in cancer

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

Autoregulatory control of mitochondrial glutathione homeostasis

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

Flp recombinase regulated lacZ expression at the ROSA26 locus

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.

Identification of specific PP2A complexes involved in human cell transformation

KRAS4A directly regulates hexokinase 1

Leveraging the iron-starvation response to promote ferroptosis

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts

Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson ⬇️