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List of works by Michael L Freeman

A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent.

scientific article published on 9 February 2007

Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway

scientific article published on 01 January 2008

Age-related retinopathy in NRF2-deficient mice.

scientific article

Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo

scientific article published on 01 September 2000

Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.

scientific article published on 21 October 2010

Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling.

scientific article published on 27 September 2006

Clusterin as a therapeutic target for radiation sensitization in a lung cancer model.

scientific article published on November 2005

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

scientific article

Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione

scientific article published on 14 September 2007

Destabilization and denaturation of cellular protein by glutathione depletion.

scientific article

Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C

scientific article published on 01 September 1997

Diamide-induced cytotoxicity and thermotolerance in CHO cells

scientific article published on 01 December 1998

Enhanced γ-Glutamyl Transpeptidase Expression and Selective Loss of CuZn Superoxide Dismutase in Hepatic Iron Overload

scientific article published on 01 March 1998

Ethnic diversity in a critical gene responsible for glutathione synthesis.

scientific article

Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux.

scientific article

Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent

scientific article published on 01 May 1997

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

scientific article published in December 2005

Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas

scientific article published on 01 September 2006

Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature

scientific article

Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.

scientific article

Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase

scientific article published on 01 April 2000

Loss of NRF2 impairs gastric nitrergic stimulation and function

scientific article

Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.

scientific article

NADPH oxidase limits innate immune responses in the lungs in mice

scientific article

Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway

scientific article published on 01 January 2007

Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents

scientific article published on 17 October 2007

Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.

scientific article

Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

scientific article (publication date: 3 October 2002)

Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives

scientific article published on August 2008

Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response

scientific article published on 01 May 1997

Radiopotentiation by the oral platinum agent, JM216: role of repair inhibition

scientific article published on 01 May 1999

Radiosensitization of cancer cells by hydroxychalcones

scientific article

Selenium deficiency activates mouse liver Nrf2-ARE but vitamin E deficiency does not

scientific article published on 31 January 2008

Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.

scientific article

Survivin as a therapeutic target for radiation sensitization in lung cancer.

scientific article published on April 2004

Synthesis of hsp-70 is enhanced in glutathione-depleted Hep G2 cells

scientific article published on 01 September 1993

The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione

scientific article

The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins

scientific article published on 9 October 2012

The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization

scientific article

Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo

scientific article

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