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List of works by Ivan Smirnov

A Study of the Protective Properties of an Antibody-Based Antidote Metabolizing Organophosphorus Pesticide Paraoxon

scientific article published on 01 June 2017

A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding ⬇️

scientific article published on 24 June 2020

A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites

scientific article

A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning.

scientific article published on 31 July 2015

Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

scientific article published on 28 April 2016

Anti-idiotypic antibody mimics proteolytic function of parent antigen.

scientific article published on 20 November 2007

Antibodies-antidotes against organophosphorus compounds.

scientific article

Antibody–antigen pair probed by combinatorial approach and rational design: Bringing together structural insights, directed evolution, and novel functionality ⬇️

scientific article published on July 25, 2012

Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning

scientific article published on 29 August 2017

CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study

scientific article published on 20 June 2016

Chemical Polysialylation of Recombinant Human Proteins

scientific article

Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo.

scientific article published on 7 January 2013

Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen.

scientific article

Creation of catalytic antibodies metabolizing organophosphate compounds.

scientific article published on October 2012

Deep Functional Profiling of Wild Animal Microbiomes Reveals Probiotic <i>Bacillus pumilus</i> Strains with a Common Biosynthetic Fingerprint

scientific article published on 21 January 2022

Design of Chemical Conjugate for Targeted Therapy of Multiple Sclerosis Based of Constant Fragment of Human Antibody Heavy Chain and Peptoid Analog of Autoantigen MOG35-55.

scientific article published on 21 April 2017

Design of targeted B cell killing agents

scientific article

Evolution of catalytic centers of antibodies by virtual screening of broad repertoire of mutants using supercomputer.

scientific article published in July 2017

Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis.

scientific article published on 23 August 2017

Genetic Engineering of Native Chain Combinations of B-Cell Repertoires on the Surface of Methylotrophic Yeasts Pichia pastoris

scientific article published on 18 July 2017

Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics.

scientific article published on 13 February 2018

Glatiramer acetate and nanny proteins restrict access of the multiple sclerosis autoantigen myelin basic protein to the 26S proteasome

scientific article

Green fluorescent genetically encoded calcium indicator based on calmodulin/M13-peptide from fungi

scientific article published on 24 August 2017

Heavy-light chain interrelations of MS-associated immunoglobulins probed by deep sequencing and rational variation

scientific article

Immunoproteasome enhances intracellular proteolysis of myelin basic protein

scientific article

Liposome-encapsulated peptides protect against experimental allergic encephalitis

scientific article

Liquid drop of DNA libraries reveals total genome information

scientific article published on 21 October 2020

Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity

scientific article

Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers

scientific article published on 28 August 2020

New Genetic Constructs for Generation of Stable Therapeutic Antibodies to Organophosphorus Toxins in Methylotrophic Yeasts Pichia Pastoris

scientific article published on 6 June 2016

Pre-steady-state kinetics of interaction of wild-type and multiple drug-resistant HIV protease with first and second generation inhibitory drugs

scientific article published on 01 September 2011

Preparation of Recombinant Serpin from Red King Crab Paralithodes сamtschaticus for Biomedical Research Purposes

scientific article published on 18 July 2017

Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

scientific article

Robotic QM/MM-driven maturation of antibody combining sites

scientific article

Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody

scientific article

Strategies for induction of catalytic antibodies toward HIV-1 glycoprotein gp120 in autoimmune prone mice.

scientific article

Strategies for the selection of catalytic antibodies against organophosphorus nerve agents ⬇️

scientific article published on November 2, 2012

The antiidiotypic approach to obtaining a proteolytic antibody.

scientific article

Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity

scientific article published on 29 January 2015

Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases

scientific article published in 2022

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