List of works - Antonio Di Stefano

(R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.

scientific article published on 2 October 2017

(R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities

scientific article published on 13 September 2012

A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation

scientific article published on 17 September 2013

Advances in prodrug design for Parkinson's disease

scientific article published on 23 January 2018

Antiparkinson prodrugs

scientific article published on 16 January 2008

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

scientific article published on 17 November 2010

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

scientific article published on 10 April 2020

Carvacrol codrugs: a new approach in the antimicrobial plan

scientific article published in 2015

Carvacrol prodrugs as novel antimicrobial agents

scientific article published on 10 June 2019

Characterization of alkanoyl-10-O-minocyclines in micellar dispersions as potential agents for treatment of human neurodegenerative disorders

scientific article published on 12 March 2008

Chelating and antioxidant properties of l-Dopa containing tetrapeptide for the treatment of neurodegenerative diseases

scientific article published on 19 June 2018

Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease.

scientific article

Design, synthesis, and preliminary pharmacological evaluation of new imidazolinones as L-DOPA prodrugs.

scientific article published on 25 January 2010

Designing prodrugs for the treatment of Parkinson's disease.

scientific article published on 12 April 2012

Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC.

scientific article published in January 2005

Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties

scientific article published on 10 December 2015

Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids

scientific article published on 29 October 2006

Drug delivery strategies for Alzheimer's disease treatment.

scientific article published on 11 March 2011

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

scientific article published on 19 June 2019

Editorial: Neurodegenerative Disorders: Synthesis, Drug Delivery Strategies and Biological Evaluation of New Therapeutic Agents.

scientific article published in January 2017

Effect of 17β-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats

scientific article published on 7 June 2014

Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration

scientific article published on 23 August 2016

Effect of choline-containing phospholipids on brain cholinergic transporters in the rat

scientific article published on 31 December 2010

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

scientific article

Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound

scientific article

Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring

scientific article published on 19 February 2019

Evaluation of rat striatal L-dopa and DA concentration after intraperitoneal administration of L-dopa prodrugs in liposomal formulations

scientific article

Evidence for a dopamine intrinsic direct role in the regulation of the ovary reproductive function: in vitro study on rabbit corpora lutea

scientific article

Glycosyl and polyalcoholic prodrugs of lonidamine.

scientific article

Graphene Oxide increases mammalian spermatozoa fertilizing ability by extracting cholesterol from their membranes and promoting capacitation.

scientific article published on 31 May 2019

HPLC-FLD and spectrofluorometer apparatus: How to best detect fluorescent probe-loaded niosomes in biological samples

scientific article published on 8 August 2015

Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.

scientific article published on 6 November 2014

Health risk assessments of lithium titanate nanoparticles in rat liver cell model for its safe applications in nanopharmacology and nanomedicine

scientific article

Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates

scientific article published on 09 May 2020

Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease.

scientific article published on 22 December 2010

Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.

scientific article published on 20 July 2011

Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.

scientific article

Ibuprofen and lipoic acid diamide as co-drug with neuroprotective activity: pharmacological properties and effects in beta-amyloid (1-40) infused Alzheimer's disease rat model.

scientific article published on April 2010

Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.

scientific article published in March 2010

L-Dopa prodrugs: an overview of trends for improving Parkinson's disease treatment.

scientific article published on January 2011

L-dopa co-drugs in nanostructured lipid carriers: A comparative study.

scientific article published on 18 November 2016

L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

scientific article published in February 2006

Lipid nanocarriers containing a levodopa prodrug with potential antiparkinsonian activity.

scientific article published on 10 December 2014

Maleic- and fumaric-diamides of (O,O-diacetyl)-L-Dopa-methylester as anti-Parkinson prodrugs in liposomal formulation.

scientific article published in November 2006

Memantine-derived drugs as potential antitumor agents for the treatment of glioblastoma

scientific article

Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease

scientific article published on 27 February 2013

Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione-L-Dopa Codrug Against H2O2-Induced Cellular Toxicity

scientific article published on 19 August 2019

Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain.

scientific article published in February 2013

NOS-mediated morphological and molecular modifications in rats infused with Aβ (1-40), as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1.

scientific article published on 8 November 2010

Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.

scientific article published on 12 April 2017

Natural oxyprenylated coumarins are modulators of melanogenesis

scientific article published on 27 April 2018

Neuroprotective effects of farnesene against hydrogen peroxide-induced neurotoxicity in vitro

scientific article published on 9 October 2013

New L-dopa codrugs as potential antiparkinson agents

scientific article published in July 2008

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

scientific article

New drug delivery strategies for improved Parkinson's disease therapy

scientific article published on 01 April 2009

New flurbiprofen derivatives: synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels

scientific article published on 3 September 2013

Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease

scientific article

Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: Development, characterization and interaction with leuprolide

article

Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation

scientific article published on 12 November 2019

Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI.

scientific article published on 6 August 2010

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease

scientific article published on 10 October 2019

Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate.

scientific article published on 8 August 2005

Potential antibacterial activity of carvacrol-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles against microbial biofilm

scientific article published on 08 August 2011

Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug.

scientific article published on 26 February 2011

Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug

Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists

scientific article published in April 2005

Prodrug approach for increasing cellular glutathione levels

scientific article published on 03 March 2010

Protective effects of cyclosativene on H2O 2-induced injury in cultured rat primary cerebral cortex cells.

scientific article

RNAIII Inhibiting Peptide (RIP) and Derivatives as Potential Tools for the Treatment of S. aureus Biofilm Infections

article

Role of Dietary Supplements in the Management of Parkinson's Disease

scientific article published on 10 July 2019

Single-Walled Carbon Nanotubes in Highly Viscous Media: A Comparison between the Dispersive Agents [BMIM][BF4 ], L121, and Triton X-100.

scientific article published on 23 October 2015

Solid lipid nanoparticles as a drug delivery system for the treatment of neurodegenerative diseases.

scientific article published on 13 April 2016

Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization.

scientific article published on 4 March 2015

Surfactant hydrogels for the dispersion of carbon-nanotube-based catalysts.

scientific article published on 21 October 2013

Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson's Disease Agents

scientific article published on 18 June 2019

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage.

scientific article published in September 2003

Synthesis and biological evaluation of GABA derivatives able to cross the blood–Brain barrier in rats ⬇️

scientific article published on November 3, 2003

Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents

scientific article published on 29 November 2018

Synthesis and preliminary pharmacological evaluation of 5-hydroxy- and 5,6-dihydroxy-1,2,3,7,12,12a-hexahydrobenzo[5,6]cyclohepta[1,2,3-ij]isoquinoline derivatives as dopamine receptor ligands.

scientific article published in June 2001

Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands

scientific article

Synthesis of L-(+)-3-(3-hydroxy-4-pivaloyloxybenzyl)-2,5-diketomorpholine as potential prodrug of L-dopa.

scientific article published in June 2000

Synthesis of a novel cyclic prodrug of S-allyl-glutathione able to attenuate LPS-induced ROS production through the inhibition of MAPK pathways in U937 cells

scientific article

Synthesis of novel 4-aryl-1,2,3,4-tetrahydroisoquinolines as probes for dopamine receptor ligands

scientific article published on 01 July 2012

Synthesis, resolution, and preliminary evaluation of trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes and related derivatives as dopamine receptors ligands

scientific article published on 01 October 1996

Temporal expression ofagrB,cidA, andalsSin the early development ofStaphylococcus aureusUAMS-1 biofilm formation and the structural role of extracellular DNA and carbohydrates

article

Toll-like receptor-2 agonist functionalized biopolymer for mucosal vaccination.

scientific article

Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione.

scientific article published in February 2004

psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine

scientific article published on 01 October 1999

List of works by Antonio Di Stefano

(R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.

(R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities

A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation

Advances in prodrug design for Parkinson's disease

Antiparkinson prodrugs

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

Carvacrol codrugs: a new approach in the antimicrobial plan

Carvacrol prodrugs as novel antimicrobial agents

Characterization of alkanoyl-10-O-minocyclines in micellar dispersions as potential agents for treatment of human neurodegenerative disorders

Chelating and antioxidant properties of l-Dopa containing tetrapeptide for the treatment of neurodegenerative diseases

Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease.

Design, synthesis, and preliminary pharmacological evaluation of new imidazolinones as L-DOPA prodrugs.

Designing prodrugs for the treatment of Parkinson's disease.

Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC.

Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties

Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids

Drug delivery strategies for Alzheimer's disease treatment.

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1

Editorial: Neurodegenerative Disorders: Synthesis, Drug Delivery Strategies and Biological Evaluation of New Therapeutic Agents.

Effect of 17β-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats

Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration

Effect of choline-containing phospholipids on brain cholinergic transporters in the rat

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound

Epigenetic Memory of Early-Life Parental Perturbation: Dopamine Decrease and DNA Methylation Changes in Offspring

Evaluation of rat striatal L-dopa and DA concentration after intraperitoneal administration of L-dopa prodrugs in liposomal formulations

Evidence for a dopamine intrinsic direct role in the regulation of the ovary reproductive function: in vitro study on rabbit corpora lutea

Glycosyl and polyalcoholic prodrugs of lonidamine.

Graphene Oxide increases mammalian spermatozoa fertilizing ability by extracting cholesterol from their membranes and promoting capacitation.

HPLC-FLD and spectrofluorometer apparatus: How to best detect fluorescent probe-loaded niosomes in biological samples

Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.

Health risk assessments of lithium titanate nanoparticles in rat liver cell model for its safe applications in nanopharmacology and nanomedicine

Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates

Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease.

Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.

Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.

Ibuprofen and lipoic acid diamide as co-drug with neuroprotective activity: pharmacological properties and effects in beta-amyloid (1-40) infused Alzheimer's disease rat model.

Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.

L-Dopa prodrugs: an overview of trends for improving Parkinson's disease treatment.

L-dopa co-drugs in nanostructured lipid carriers: A comparative study.

L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

Lipid nanocarriers containing a levodopa prodrug with potential antiparkinsonian activity.

Maleic- and fumaric-diamides of (O,O-diacetyl)-L-Dopa-methylester as anti-Parkinson prodrugs in liposomal formulation.

Memantine-derived drugs as potential antitumor agents for the treatment of glioblastoma

Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease

Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione-L-Dopa Codrug Against H2O2-Induced Cellular Toxicity

Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain.

NOS-mediated morphological and molecular modifications in rats infused with Aβ (1-40), as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1.

Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.

Natural oxyprenylated coumarins are modulators of melanogenesis

Neuroprotective effects of farnesene against hydrogen peroxide-induced neurotoxicity in vitro

New L-dopa codrugs as potential antiparkinson agents

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

New drug delivery strategies for improved Parkinson's disease therapy

New flurbiprofen derivatives: synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels

Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease

Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: Development, characterization and interaction with leuprolide

Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation

Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI.

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease

Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate.

Potential antibacterial activity of carvacrol-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles against microbial biofilm

Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug.

Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug

Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists

Prodrug approach for increasing cellular glutathione levels

Protective effects of cyclosativene on H2O 2-induced injury in cultured rat primary cerebral cortex cells.

RNAIII Inhibiting Peptide (RIP) and Derivatives as Potential Tools for the Treatment of S. aureus Biofilm Infections

Role of Dietary Supplements in the Management of Parkinson's Disease

Single-Walled Carbon Nanotubes in Highly Viscous Media: A Comparison between the Dispersive Agents [BMIM][BF4 ], L121, and Triton X-100.

Solid lipid nanoparticles as a drug delivery system for the treatment of neurodegenerative diseases.

Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization.

Surfactant hydrogels for the dispersion of carbon-nanotube-based catalysts.

Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson's Disease Agents

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage.

Synthesis and biological evaluation of GABA derivatives able to cross the blood–Brain barrier in rats ⬇️

Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents

Synthesis and preliminary pharmacological evaluation of 5-hydroxy- and 5,6-dihydroxy-1,2,3,7,12,12a-hexahydrobenzo[5,6]cyclohepta[1,2,3-ij]isoquinoline derivatives as dopamine receptor ligands.