List of works - Manu Platt

Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice.

scientific article published on 25 April 2013

Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB.

scientific article published in May 2016

Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.

scientific article published on 19 October 2015

Cathepsin S Cannibalism of Cathepsin K as a Mechanism to Reduce Type I Collagen Degradation ⬇️

scientific article published on June 22, 2012

Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model

scientific article published on 6 January 2015

Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium

scientific article published on 01 May 2019

Co-emergence of Specialized Endothelial Cells from Embryonic Stem Cells.

scientific article published on 10 January 2018

Computational imaging analysis of fibrin matrices with the inclusion of erythrocytes from homozygous SS blood reveals agglomerated and amorphous structures.

scientific article published on 23 September 2016

Computational predictions of cysteine cathepsin-mediated fibrinogen proteolysis

scientific article published on 20 December 2017

Crohn's disease: a review of treatment options and current research

scientific article

Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche

scientific article published on 04 November 2020

Detection of femtomole quantities of mature cathepsin K with zymography.

scientific article

Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells

scientific article published on 19 June 2019

Efavirenz treatment causes arterial stiffening in apolipoprotein E-null mice.

scientific article published on 21 May 2015

Endothelial cells and cathepsins: Biochemical and biomechanical regulation

scientific article published on 9 October 2015

Experimental and imaging techniques for examining fibrin clot structures in normal and diseased states.

scientific article

Heat shock and cold shock in Deinococcus radiodurans.

scientific article published in January 2004

Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines.

scientific article

MMP-mediated mesenchymal morphogenesis of pluripotent stem cell aggregates stimulated by gelatin methacrylate microparticle incorporation

scientific article published on 21 October 2015

Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues

scientific article

Molecular insights into the irreversible mechanical behavior of sickle hemoglobin.

scientific article published on 13 April 2018

Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.

scientific article

Multiplex Cathepsin Zymography to Detect Amounts of Active Cathepsins K, L, S, and V.

scientific article published in January 2017

Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.

scientific article

Novel in vivo and in vitro techniques to image and model the cerebral vasculature in sickle cell disease.

scientific article published on 12 August 2017

Original Research: Sickle cell anemia and pediatric strokes: Computational fluid dynamics analysis in the middle cerebral artery

scientific article published on 04 March 2016

Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation.

scientific article

Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells.

scientific article

Reassessing enzyme kinetics: Considering protease-as-substrate interactions in proteolytic networks

scientific article published on 24 January 2020

Sickle cell biomechanics.

scientific article published on August 2010

Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells.

scientific article published on 9 April 2012

Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice

scientific article published on 01 March 2022

Systematic optimization of multiplex zymography protocol to detect active cathepsins K, L, S, and V in healthy and diseased tissue: compromise among limits of detection, reduced time, and resources

scientific article

Tumor cell-organized fibronectin maintenance of a dormant breast cancer population

scientific article published on 11 March 2020

List of works by Manu Platt

Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice.

Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB.

Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.

Cathepsin S Cannibalism of Cathepsin K as a Mechanism to Reduce Type I Collagen Degradation ⬇️

Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model

Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium

Co-emergence of Specialized Endothelial Cells from Embryonic Stem Cells.

Computational imaging analysis of fibrin matrices with the inclusion of erythrocytes from homozygous SS blood reveals agglomerated and amorphous structures.

Computational predictions of cysteine cathepsin-mediated fibrinogen proteolysis

Crohn's disease: a review of treatment options and current research

Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche

Detection of femtomole quantities of mature cathepsin K with zymography.

Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells

Efavirenz treatment causes arterial stiffening in apolipoprotein E-null mice.

Endothelial cells and cathepsins: Biochemical and biomechanical regulation

Experimental and imaging techniques for examining fibrin clot structures in normal and diseased states.

Heat shock and cold shock in Deinococcus radiodurans.

Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines.

MMP-mediated mesenchymal morphogenesis of pluripotent stem cell aggregates stimulated by gelatin methacrylate microparticle incorporation

Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues

Molecular insights into the irreversible mechanical behavior of sickle hemoglobin.

Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.

Multiplex Cathepsin Zymography to Detect Amounts of Active Cathepsins K, L, S, and V.

Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.

Novel in vivo and in vitro techniques to image and model the cerebral vasculature in sickle cell disease.

Original Research: Sickle cell anemia and pediatric strokes: Computational fluid dynamics analysis in the middle cerebral artery

Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation.

Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells.

Reassessing enzyme kinetics: Considering protease-as-substrate interactions in proteolytic networks

Sickle cell biomechanics.

Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells.

Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice

Systematic optimization of multiplex zymography protocol to detect active cathepsins K, L, S, and V in healthy and diseased tissue: compromise among limits of detection, reduced time, and resources

Tumor cell-organized fibronectin maintenance of a dormant breast cancer population