List of works by Maria Rosalia Pasca

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1

scientific article

4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity

scientific article

A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in <i>Mycobacterium tuberculosis</i>

scientific article published on 22 February 2021

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors

scientific article published on 5 May 2017

A census of RND superfamily proteins in the Burkholderia genus

scientific article

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

scientific article published on 16 February 2018

Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis

scientific article published in 2011

Antituberculars which target decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1: state of art.

scientific article published on 18 April 2012

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

scientific article published on 17 September 2009

Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system

scientific article

Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1.

scientific article

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

scientific journal article

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

scientific article

Characterization and heterologous expression of the oxalyl coenzyme A decarboxylase gene from Bifidobacterium lactis

scientific article

Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents.

scientific article published on 23 March 2012

Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones

scientific article

Control of MRSA infection and colonisation in an intensive care unit by GeneOhm MRSA assay and culture methods

scientific article published on 24 August 2009

Deciphering the role of RND efflux transporters in Burkholderia cenocepacia

scientific article

Design and Synthesis of Pyrano[3,2-<i>b</i>]indolones Showing Antimycobacterial Activity

scientific article published on 22 December 2020

Design, chemical synthesis of 3-(9H-fluoren-9-yl)pyrrolidine-2,5-dione derivatives and biological activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis

scientific article published on 2 October 2013

Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth.

scientific article published on 20 June 2015

Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells

scientific article published on 29 September 2014

DprE1, a new taxonomic marker in mycobacteria

scientific article published on 12 September 2013

Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome

scientific article

Evaluation of fluoroquinolone resistance mechanisms in Pseudomonas aeruginosa multidrug resistance clinical isolates.

scientific article

Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis.

scientific article published on 14 June 2016

Exploring the HME and HAE1 efflux systems in the genus Burkholderia

scientific article

Genomic analysis of zinc homeostasis in Mycobacterium tuberculosis

scientific article published on October 2008

Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon

scientific journal article

Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain

scientific article

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

scientific article

Iron Acquisition Pathways as Targets for Antitubercular Drugs

scientific article

LfrR is a repressor that regulates expression of the efflux pump LfrA in Mycobacterium smegmatis

scientific article

Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity

scientific article published in September 2017

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

scientific article

Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis

scientific article

Mycobacterium tuberculosis: drug resistance and future perspectives

scientific article published on June 2009

New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053

scientific article published on 02 December 2019

New and Old Hot Drug Targets in Tuberculosis.

scientific article published on 31 August 2016

New prodrugs against tuberculosis.

scientific article published on 17 September 2016

Nitric oxide-releasing compounds for the treatment of lung infections

scientific article published on 09 November 2020

Phenotypic and genotypic characterisation of Burkholderia cenocepacia J2315 mutants affected in homoserine lactone and diffusible signal factor-based quorum sensing systems suggests interplay between both types of systems

scientific article

Pyrrolidinone and pyrrolidine derivatives: Evaluation as inhibitors of InhA and Mycobacterium tuberculosis.

scientific article published on 16 July 2016

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis

scientific article

Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis

scientific journal article

Shifts of Faecal Microbiota During Sporadic Colorectal Carcinogenesis.

scientific article published on 9 July 2018

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

scientific article

Synthesis and biological activities of triazole derivatives as inhibitors of InhA and antituberculosis agents

scientific article published on 16 September 2011

Synthesis and evaluation of α-ketotriazoles and α,β-diketotriazoles as inhibitors of Mycobacterium tuberculosis.

scientific article published on 8 July 2013

Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis

scientific article published on 04 November 2013

The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

scientific article published on 14 September 2013

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.

scientific article

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

scientific article published on 18 June 2015

Trends in discovery of new drugs for tuberculosis therapy

scientific article published on 06 August 2014

Triazolophthalazines: Easily Accessible Compounds with Potent Antitubercular Activity.

scientific article

mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis

scientific article

Paulina is supported by:

About Paulina

Help