List of works by John Koren

Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer

scientific article

Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy

scientific article published on 12 December 2008

Chaperone signalling complexes in Alzheimer's disease.

scientific article published on April 2009

Chemical manipulation of hsp70 ATPase activity regulates tau stability.

scientific article published on September 2009

Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

scientific article

Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism

scientific article

HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization

scientific article

Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

scientific article

Hsc70 rapidly engages tau after microtubule destabilization

scientific article

Hsp90 activator Aha1 drives production of pathological tau aggregates

scientific article published on 21 August 2017

Hsp90 and FKBP51: complex regulators of psychiatric diseases.

scientific article published in January 2018

Human cyclophilin 40 unravels neurotoxic amyloids

scientific article

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.

scientific article published on 22 December 2017

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

scientific article published on 20 December 2017

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.

scientific article

Neuronal life span versus health span: principles of natural selection at work in the degenerating brain.

scientific article published on 11 May 2011

Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

scientific article

RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures

scientific article published on 26 September 2016

Reconstructing the Hsp90/Tau Machine.

scientific article published in January 2013

Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention

scientific article published in January 2014

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

scientific article

Stressing Out Hsp90 in Neurotoxic Proteinopathies.

scientific article published on 13 April 2016

Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD

scientific article published on 19 June 2018

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

scientific article

The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.

scientific article

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

scientific article published on 16 January 2020

The epichaperome is an integrated chaperome network that facilitates tumour survival

scientific article published on 05 October 2016

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.

scientific article published on 5 February 2018

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