List of works - Richard Dobson

A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations

scientific article published on 29 March 2018

A Meta-Analysis of Alzheimer’s Disease Brain Transcriptomic Data

scientific article published on 01 January 2019

A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data

scientific article

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease

scientific article

A blood gene expression biomarker of early Alzheimer's disease

article

A blood gene expression marker of early Alzheimer's disease

scientific article published on January 2013

A comparison of machine learning methods for classification using simulation with multiple real data examples from mental health studies

scientific article

A patient flow simulator for healthcare management education

article

ACE-inhibitors and Angiotensin-2 Receptor Blockers are not associated with severe SARS- COVID19 infection in a multi-site UK acute Hospital Trust

scientific article published on 11 April 2020

ADEPt, a semantically-enriched pipeline for extracting adverse drug events from free-text electronic health records.

scientific article published on 9 November 2017

Alzheimer's disease: are blood and brain markers related? A systematic review

scientific article published on 11 May 2016

Analysis of diagnoses extracted from electronic health records in a large mental health case register.

scientific article

Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables.

scientific article

Are blood-based protein biomarkers for Alzheimer's disease also involved in other brain disorders? A systematic review

scientific article published on January 2015

Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis

scientific article published on 31 May 2016

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

scientific article

Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer.

scientific article

Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

scientific article published on 01 March 2020

Author Correction: Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

scientific article published on 6 March 2018

Automated PDF highlighting to support faster curation of literature for Parkinson's and Alzheimer's disease

scientific article

BBGRE: brain and body genetic resource exchange

scientific article published on 27 September 2013

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

scientific article published on 20 November 2019

Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology

scientific article published on 16 April 2015

Blood pressure loci identified with a gene-centric array

scientific article

Blood protein predictors of brain amyloid for enrichment in clinical trials?

scientific article published on 29 March 2015

Blood-based biomarker discovery using aptamer capture (SOMAscan) platform technology

Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease

scientific article

Capturing Rest-Activity Profiles in Schizophrenia Using Wearable and Mobile Technologies: Development, Implementation, Feasibility, and Acceptability of a Remote Monitoring Platform

article

Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study

article

Circulating Proteomic Signatures of Chronological Age.

scientific article published on 14 August 2014

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

scientific article

CogStack - experiences of deploying integrated information retrieval and extraction services in a large National Health Service Foundation Trust hospital.

scientific article

CohortExplorer: A Generic Application Programming Interface for Entity Attribute Value Database Schemas.

scientific article

Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression

scientific article published in January 2011

Combining clinical variables to optimize prediction of antidepressant treatment outcomes

scientific article published in April 2016

Combining string and phonetic similarity matching to identify misspelt names of drugs in medical records written in Portuguese

scientific article published on 12 November 2019

Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease

scientific article

DNAscan: personal computer compatible NGS analysis, annotation and visualisation

scientific article published on 27 April 2019

Differential gene expression analysis in blood of first episode psychosis patients

scientific article published on 19 May 2019

Dysregulated Antibody, Natural Killer Cell and Immune Mediator Profiles in Autoimmune Thyroid Diseases

scientific article published on 09 March 2020

Efficient Reuse of Natural Language Processing Models for Phenotype-Mention Identification in Free-text Electronic Medical Records: A Phenotype Embedding Approach

scientific article published on 17 December 2019

Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort

scientific article published on 25 May 2022

Filaggrin mutations are associated with ichthyosis vulgaris in the Bangladeshi population.

scientific article published on 9 March 2009

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

scientific article

Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid

scientific article

Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: the GENRA case-control study

scientific article published on 12 April 2017

Genetics of essential hypertension

scientific article published on 5 February 2004

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

scientific article published on January 2010

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

scientific article

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

scientific article

Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

scientific article published on 22 November 2020

Genome-wide mapping of human loci for essential hypertension

scientific article

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations

scientific article published on 20 March 2009

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

article

Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children

scientific article

Human-Centered Design Strategies for Device Selection in mHealth Programs: Development of a Novel Framework and Case Study

scientific article published on 07 May 2020

Identification of Adverse Drug Events from Free Text Electronic Patient Records and Information in a Large Mental Health Case Register

scientific article

Identification of cis-regulatory variation influencing protein abundance levels in human plasma.

scientific article published on 16 May 2012

Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis

scientific article published on 05 May 2016

In response to Ballantyne and Schaefer’s ‘Consent and the ethical duty to participate in health data research’

article

Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study

article

Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates

scientific article published on 25 September 2007

Interaction between Ostertagia circumcincta and Haemonchus contortus infection in young lambs ⬇️

scientific article published on April 1, 1995

Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion.

scientific article

Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

scientific article published on 27 November 2017

Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence ⬇️

scientific article published on 02 April 2020

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension

scientific article

Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts

scientific article published on January 2015

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

scientific article published on 17 May 2018

Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders.

scientific article

Mapping multimorbidity in individuals with schizophrenia and bipolar disorders: evidence from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register

scientific article published on 24 January 2022

Microdeletions of ELP4 Are Associated with Language Impairment, Autism Spectrum Disorder, and Mental Retardation

scientific article published on 23 May 2015

Mining Social Media Data to Study the Consequences of Dementia Diagnosis on Caregivers and Relatives (Preprint)

scholarly article published 26 March 2018

Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood

scientific article published on January 2012

Mitochondrial genes are altered in blood early in Alzheimer's disease

scientific article

Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death

scientific article published on 12 November 2019

Natural language processing to extract symptoms of severe mental illness from clinical text: the Clinical Record Interactive Search Comprehensive Data Extraction (CRIS-CODE) project.

scientific article

Network analysis of patient flow in two UK acute care hospitals identifies key sub-networks for A&E performance.

scientific article published on 2 October 2017

No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease

scientific article published in August 2015

No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents

scientific article published in January 2014

Novel protein vaccine candidates against Group B streptococcal infection identified using alkaline phosphatase fusions.

scientific article published in May 2003

Plasma based markers of [11C] PiB-PET brain amyloid burden

scientific article

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease

scientific article

Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes

scientific article published on 16 June 2015

Plasma proteins predict conversion to dementia from prodromal disease

scientific article

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion

scientific article

Populations of strongyloid nematode infective stages in sheep pastures: Comparison between direct pasture sampling and tracer lambs as estimators of larval abundance ⬇️

scientific article published on October 1, 1981

Predicting deleterious nsSNPs: an analysis of sequence and structural attributes

scientific article published on 21 April 2006

Preserving new anthelmintics: A simple method for estimating faecal egg count reduction test (FECRT) confidence limits when efficacy and/or nematode aggregation is high ⬇️

scientific article published on November 20, 2011

Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties

scientific article

Proteomic blood profiling in mild, severe and critical COVID-19 patients

scientific article published on 18 March 2021

RADAR-Base: Open Source Mobile Health Platform for Collecting, Monitoring, and Analyzing Data Using Sensors, Wearables, and Mobile Devices

scientific article published on 01 August 2019

Regional performance variation in external validation of four prediction models for severity of COVID-19 at hospital admission: An observational multi-centre cohort study

scientific article published on 25 August 2021

Remote Assessment of Disease and Relapse in Epilepsy: Protocol for a Multicenter Prospective Cohort Study

scientific article published on 16 December 2020

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression

scientific article published on 24 June 2011

SLC2A9 is a high-capacity urate transporter in humans

scientific article

SemEHR: A general-purpose semantic search system to surface semantic data from clinical notes for tailored care, trial recruitment, and clinical research.

scientific article published on 19 January 2018

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

scientific article published on 28 January 2022

Supplementing the National Early Warning Score (NEWS2) for anticipating early deterioration among patients with COVID-19 infection

scientific article published on 29 April 2020

Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array

scientific article

Telomere length is greater in ALS than in controls: a whole genome sequencing study

scientific article published on 01 April 2019

TextHunter--A User Friendly Tool for Extracting Generic Concepts from Free Text in Clinical Research

scientific article published on 14 November 2014

The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.

scientific article published on 6 July 2018

The potential of nematophagous fungi to control the free-living stages of nematode parasites of sheep: Pasture plot study with Duddingtonia flagrans ⬇️

scientific article published on March 31, 1998

Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents

scientific article

Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort

scientific article

Transcriptomic analysis of probable asymptomatic and symptomatic alzheimer brains

scientific article published on 04 May 2019

Transcriptomics and the mechanisms of antidepressant efficacy

scientific article published on 12 November 2015

Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension

article

UK phenomics platform for developing and validating EHR phenotypes: CALIBER

UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER

scientific article published on 01 December 2019

List of works by Richard Dobson

A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations

A Meta-Analysis of Alzheimer’s Disease Brain Transcriptomic Data

A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease

A blood gene expression biomarker of early Alzheimer's disease

A blood gene expression marker of early Alzheimer's disease

A comparison of machine learning methods for classification using simulation with multiple real data examples from mental health studies

A patient flow simulator for healthcare management education

ACE-inhibitors and Angiotensin-2 Receptor Blockers are not associated with severe SARS- COVID19 infection in a multi-site UK acute Hospital Trust

ADEPt, a semantically-enriched pipeline for extracting adverse drug events from free-text electronic health records.

Alzheimer's disease: are blood and brain markers related? A systematic review

Analysis of diagnoses extracted from electronic health records in a large mental health case register.

Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables.

Are blood-based protein biomarkers for Alzheimer's disease also involved in other brain disorders? A systematic review

Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer.

Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

Author Correction: Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

Automated PDF highlighting to support faster curation of literature for Parkinson's and Alzheimer's disease

BBGRE: brain and body genetic resource exchange

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology

Blood pressure loci identified with a gene-centric array

Blood protein predictors of brain amyloid for enrichment in clinical trials?

Blood-based biomarker discovery using aptamer capture (SOMAscan) platform technology

Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease

Capturing Rest-Activity Profiles in Schizophrenia Using Wearable and Mobile Technologies: Development, Implementation, Feasibility, and Acceptability of a Remote Monitoring Platform

Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study

Circulating Proteomic Signatures of Chronological Age.

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

CogStack - experiences of deploying integrated information retrieval and extraction services in a large National Health Service Foundation Trust hospital.

CohortExplorer: A Generic Application Programming Interface for Entity Attribute Value Database Schemas.

Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression

Combining clinical variables to optimize prediction of antidepressant treatment outcomes

Combining string and phonetic similarity matching to identify misspelt names of drugs in medical records written in Portuguese

Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease

DNAscan: personal computer compatible NGS analysis, annotation and visualisation

Differential gene expression analysis in blood of first episode psychosis patients

Dysregulated Antibody, Natural Killer Cell and Immune Mediator Profiles in Autoimmune Thyroid Diseases

Efficient Reuse of Natural Language Processing Models for Phenotype-Mention Identification in Free-text Electronic Medical Records: A Phenotype Embedding Approach

Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort

Filaggrin mutations are associated with ichthyosis vulgaris in the Bangladeshi population.

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid

Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: the GENRA case-control study

Genetics of essential hypertension

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

Genome-wide mapping of human loci for essential hypertension

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children

Human-Centered Design Strategies for Device Selection in mHealth Programs: Development of a Novel Framework and Case Study

Identification of Adverse Drug Events from Free Text Electronic Patient Records and Information in a Large Mental Health Case Register

Identification of cis-regulatory variation influencing protein abundance levels in human plasma.

Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis

In response to Ballantyne and Schaefer’s ‘Consent and the ethical duty to participate in health data research’

Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study

Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates

Interaction between Ostertagia circumcincta and Haemonchus contortus infection in young lambs ⬇️

Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion.

Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence ⬇️

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension

Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders.

Mapping multimorbidity in individuals with schizophrenia and bipolar disorders: evidence from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register

Microdeletions of ELP4 Are Associated with Language Impairment, Autism Spectrum Disorder, and Mental Retardation

Mining Social Media Data to Study the Consequences of Dementia Diagnosis on Caregivers and Relatives (Preprint)

Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood

Mitochondrial genes are altered in blood early in Alzheimer's disease

Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death

Natural language processing to extract symptoms of severe mental illness from clinical text: the Clinical Record Interactive Search Comprehensive Data Extraction (CRIS-CODE) project.

Network analysis of patient flow in two UK acute care hospitals identifies key sub-networks for A&E performance.