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List of works by Hyunbum Jang

A New View of Pathway-Driven Drug Resistance in Tumor Proliferation

scientific article published on 25 February 2017

A New View of Ras Isoforms in Cancers

scientific article

Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores

scientific article

All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

scientific article

Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles

scientific article published on 24 July 2018

Allostery in Its Many Disguises: From Theory to Applications

scientific article published on 07 February 2019

Alzheimer's disease: which type of amyloid-preventing drug agents to employ?

scientific article

Alzheimer's β-Amyloid All-D-Enantiomers and Native All-L-Enantiomers Exhibit Similar Pore Structures in Lipid Bilayers: Atomic Force Microscopy

Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts

scientific article

Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42

scientific article published on 06 May 2008

Antimicrobial properties of amyloid peptides

scientific article published on 29 November 2011

Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link

scientific article

Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies

scientific article

Are Parallel Proliferation Pathways Redundant?

scientific article published on 25 April 2020

Arl2-Mediated Allosteric Release of Farnesylated KRas4B from Shuttling Factor PDEδ

scientific article published on 18 July 2018

Assembly and kinetic folding pathways of a tetrameric beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models

scientific article

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology

scientific article

Autoinhibition can identify rare driver mutations and advise pharmacology

scientific article published on 22 November 2019

Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention

scientific article published on 29 September 2018

Beta2-microglobulin amyloid fragment organization and morphology and its comparison to Abeta suggests that amyloid aggregation pathways are sequence specific

scientific article

Ca2+-Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1

scientific article published on 26 November 2019

Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α

scientific article published on 08 August 2018

Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers

scientific article published on 30 October 2017

Calmodulin and PI3K Signaling in KRAS Cancers

scientific article published on 18 February 2017

Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences

scientific article

Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

scientific article

Computational Structural Biology: Successes, Future Directions, and Challenges

Conformational study of the protegrin-1 (PG-1) dimer interaction with lipid bilayers and its effect

scientific article

Correction: Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

scientific article published on 12 June 2019

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

scientific article

Does Ras Activate Raf and PI3K Allosterically?

scientific article published on 15 November 2019

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

scientific article

Dynamic Protein Allosteric Regulation and Disease

scientific article published on 01 January 2019

Dynamic multiprotein assemblies shape the spatial structure of cell signaling

scientific article

Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations

scientific article published on 28 March 2012

Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment

scientific article

Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.

scientific article published on 16 June 2017

Folding thermodynamics of model four-strand antiparallel beta-sheet proteins

scientific article

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

scientific article

GTP-Dependent K-Ras Dimerization

scientific article published on 4 June 2015

Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations

scientific article published on 12 June 2017

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

scientific article

High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-Terminal Proline-Rich Domain of SOS1

scientific article published on 04 February 2020

How environment supports a state: molecular dynamics simulations of two states in bacteriorhodopsin suggest lipid and water compensation

scientific article

How to lose a kink and gain a helix: pH independent conformational changes of the fusion domains from influenza hemagglutinin in heterogeneous lipid bilayers

scientific article

Independent and core pathways in oncogenic KRAS signaling

scientific article published on 7 July 2016

Inhibitors of Ras-SOS Interactions

scientific article published on 2 December 2015

Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit.

scientific article

Interaction of protegrin-1 with lipid bilayers: membrane thinning effect

scientific article

Interface Localization in Thin Films

1999 doctoral thesis by Hyunbum Jang at University of Auckland

Intrinsic protein disorder in oncogenic KRAS signaling

scientific article

Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?

scientific article published on 4 January 2018

K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?

scientific article published on 12 February 2016

K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis

scientific article published on October 2009

Material properties of matrix lipids determine the conformation and intermolecular reactivity of diacetylenic phosphatidylcholine in the lipid bilayer

scientific article published on 21 November 2011

Mechanism of membrane permeation induced by synthetic β-hairpin peptides

scientific article

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

scientific article

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

scientific article

Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction

scientific article published on 01 May 2020

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers

scientific article

Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels

scientific article published on December 2009

Modeling Alzheimer's Ion Channel Structures in Lipid Bilayers Formed by D- and L-Enantiomers of Beta-Amyloid (1-42) Peptide

Modeling Ion-Permeable β-Amyloid (Aβ) Barrels in the Lipid Bilayer

Modeling Variants of Alzheimer's Ion Channels in the Lipid Bilayer formed by an Aggregation-Intermediate β-Hairpin and E22Δ Mutant

Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities

scientific article

Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process

scientific article

Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels

scientific article published on 15 August 2008

Multiple pathways in conformational transitions of the alanine dipeptide: an application of dynamic importance sampling

scientific article published on 01 August 2006

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

scientific article published on 15 November 2018

New structures help the modeling of toxic amyloidbeta ion channels

scientific article published on 07 January 2008

Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

scientific article published on 10 July 2020

Oligomerization and nanocluster organization render specificity

scientific article

Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling

scientific article published on 10 January 2020

Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation

scientific article published on 4 April 2016

Oncogenic KRas mobility in the membrane and signaling response.

scientific article published on 27 February 2018

Oncogenic Ras Isoforms Signaling Specificity at the Membrane

scientific article published on 22 December 2017

PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization.

scientific article published on 25 May 2017

PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective

scientific article published on 12 October 2020

PI3K inhibitors: review and new strategies

scientific article published on 19 May 2020

Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains

scientific article published in November 2017

Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition

scientific article published on 07 December 2020

Plasma membrane regulates Ras signaling networks

scientific article published on October 2015

Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation

scientific article

Precision medicine review: rare driver mutations and their biophysical classification

article

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

scientific article published on 23 October 2015

Probing ion channel activity of human islet amyloid polypeptide (amylin).

scientific article

Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions

scientific article published on 12 January 2012

Protein ensembles link genotype to phenotype.

scientific article published on 20 June 2019

Protein folding pathways and kinetics: molecular dynamics simulations of beta-strand motifs.

scientific article

RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro

scientific article published on 16 September 2016

Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling

scientific article published on 29 January 2018

Ras Conformational Ensembles, Allostery, and Signaling

scientific article published on 27 January 2016

Ras assemblies and signaling at the membrane

scientific article published on 04 February 2020

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

article

Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability

scientific article

SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations

scientific article published on 01 July 2020

Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

scientific article published on 09 September 2020

Structural convergence among diverse, toxic beta-sheet ion channels

scientific article

Structure–Function Studies of Amyloid Pores in Alzheimer’s Disease as a Case Example of Neurodegenerative Diseases

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

scientific article

The Mystery of Rap1 Suppression of Oncogenic Ras

scientific article published on 02 March 2020

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.

scientific article published on 23 February 2016

The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin

scientific article published on 05 September 2019

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

scientific article published on 19 December 2015

The dynamic mechanism of RASSF5 and MST kinase activation by Ras.

scientific article published on 15 February 2017

The higher level of complexity of K-Ras4B activation at the membrane

scientific article published on 30 December 2015

The mechanism of PI3Kα activation at the atomic level

scientific article published on 20 February 2019

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

scientific article published on 17 April 2021

The quaternary assembly of KRas4B with Raf-1 at the membrane

scientific article published on 25 March 2020

The structural basis for Ras activation of PI3Kα lipid kinase

scientific article published on 01 June 2019

The structural basis for cancer treatment decisions

scientific article

The structural basis of Akt PH domain interaction with calmodulin

scientific article published on 26 March 2021

Thermodynamics and stability of a beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models

scientific article published in January 2004

Tools for channels: moving towards molecular calculations of gating and permeation in ion channel biophysics

scientific article published on May 2004

Transmembrane β-Barrel Topology Model for Alzheimer's β-Amyloid (Aβ) Ion Channels

article published in 2011

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

scientific article

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.

scientific article published on 22 January 2018

Why Are Some Driver Mutations Rare?

scientific article published on 05 November 2019

β-Barrel topology of Alzheimer's β-amyloid ion channels

scientific article

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