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List of works by Luigi E Xodo

(A,G)-oligonucleotides form extraordinary stable triple helices with a critical R.Y sequence of the murine c-Ki-ras promoter and inhibit transcription in transfected NIH 3T3 cells.

scientific article

A photodynamic bifunctional conjugate for prostate cancer: an in vitro mechanistic study

scientific article published on 11 October 2016

Anti-gene effect in live cells of AG motif triplex-forming oligonucleotides containing an increasing number of phosphorothioate linkages.

scientific article

Anti-gene strategies to down-regulate gene expression in mammalian cells.

scientific article published on January 2004

Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies

scientific article

Antigene effect in K562 cells of a PEG-conjugated triplex-forming oligonucleotide targeted to the bcr/abl oncogene

scientific article

Antigene property of PNA conjugated to the nuclear localization signal peptide.

scientific article published on January 2005

Antisense locked nucleic acids efficiently suppress BCR/ABL and induce cell growth decline and apoptosis in leukemic cells

scientific article published on 01 July 2006

Applications of the photodynamic therapy to cancer,water- and vector-borne diseases

scientific article published on 01 January 2012

Characterization of the DNA triplex formed by d(TGGGTGGGTGGTTGGGTGGG) and a critical R.Y sequence located in the promoter of the murine Ki-ras proto-oncogene.

scientific article

Conjugated PDT drug: photosensitizing activity and tissue distribution of PEGylated pheophorbide a.

scientific article published in September 2010

Critical role of hnRNP A1 in activating KRAS transcription in pancreatic cancer cells: A molecular mechanism involving G4 DNA.

scientific article

Delayed cord clamping and cord gas analysis at birth.

scientific article published on 16 September 2017

Effect of cations on purine.purine.pyrimidine triple helix formation in mixed-valence salt solutions

scientific article published on 01 March 1999

Effect of phosphorothioate modifications on the ability of GTn oligodeoxynucleotides to specifically recognize single-stranded DNA-binding proteins and to affect human cancer cellular growth.

scientific article

Efficient silencing of bcr/abl oncogene by single- and double-stranded siRNAs targeted against b2a2 transcripts.

scientific article published in December 2004

Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): a comparative study with TMPyP4.

scientific article published on 6 September 2010

Evidence that photoactivated pheophorbide a causes in human cancer cells a photodynamic effect involving lipid peroxidation.

scientific article

Folate-Decorated Amphiphilic Cyclodextrins as Cell-Targeted Nanophototherapeutics

scientific article published on 25 June 2019

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

scientific article published on 10 May 2006

G-rich oligonucleotide inhibits the binding of a nuclear protein to the Ki-ras promoter and strongly reduces cell growth in human carcinoma pancreatic cells.

scientific article published on March 2004

G4 DNA in ras genes and its potential in cancer therapy

scientific article published on 4 February 2016

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy

scientific article

GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1

scientific article

Guanidino Anthrathiophenediones as G-Quadruplex Binders: Uptake, Intracellular Localization, and Anti-Harvey-ras Gene Activity in Bladder Cancer Cells ⬇️

scientific article published on March 21, 2013

HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property.

scientific article

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells

scientific article

Inhibition of gene expression by peptide nucleic acids in cultured cells.

scientific article published on May 2003

Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells.

scientific article published on 08 December 2016

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

scientific article published on 6 March 2013

Metallation of pentaphyrin with Lu(III) dramatically increases reactive-oxygen species production and cell phototoxicity.

scientific article published on 14 December 2010

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

scholarly article by Annalisa Ferino published in October 2018

Nanocrystalline cellulose-fullerene: Novel conjugates.

scientific article published on 23 January 2017

Nitric oxide-mediated activity in anti-cancer photodynamic therapy.

scientific article published on 26 January 2013

Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism.

scientific article

On the interaction of daunomycin with synthetic alternating DNAs: sequence specificity and polyelectrolyte effects on the intercalation equilibrium

scientific article published on 01 November 1988

PNA conjugated to high-molecular weight poly(ethylene glycol): synthesis and properties.

scientific article published in January 2007

Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5'-UTR of KRAS oncogene represses translation.

scientific article

Photodynamic Therapy for ras-Driven Cancers: Targeting G-Quadruplex RNA Structures with Bifunctional Alkyl-Modified Porphyrins

scientific article published on 24 January 2020

Photooxidation and Phototoxicity of pi-extended squaraines

scientific article published in March 2010

Photosensitizers binding to nucleic acids as anticancer agents

scientific article

Potent Apoptotic Response Induced by Chloroacetamidine Anthrathiophenediones in Bladder Cancer Cells

scientific article published on 30 June 2015

Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE ⬇️

scientific article published on March 22, 2011

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

scientific article published on 12 March 2009

Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation

scientific article published on 2 May 2008

Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition.

scientific article published on August 1994

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

scientific article published on 15 November 2017

Repeated sub-optimal photodynamic treatments with pheophorbide a induce an epithelial mesenchymal transition in prostate cancer cells via nitric oxide

scientific article

Role of NF-κB/Snail/RKIP loop in the response of tumor cells to photodynamic therapy

scientific article

Role of Poly [ADP-ribose] Polymerase 1 in Activating the Kirsten ras (KRAS) Gene in Response to Oxidative Stress

scientific article published on 28 August 2020

Sequence specificity in the interaction of daunomycin with alternating polydeoxynucleotides

scientific article published on 01 May 1988

Sequence-specific DNA-triplex formation at imperfect homopurine-homopyrimidine sequences within a DNA plasmid.

scientific article

Site-directed inhibition of DNA replication by triple helix formation.

scientific article published on December 2001

Small interfering RNA-mediated silencing of glutathione-S-transferase A1 sensitizes hepatic carcinoma cells to photodynamic therapy with pentaphyrins

scientific article published on April 2008

Spectroscopic and calorimetric investigation on the DNA triplex formed by d(CTCTTCTTTCTTTTCTTTCTTCTC) and d(GAGAAGAAAGA) at acidic pH

scientific article published in June 1990

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

scientific article

The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element

scientific article

The PDT activity of free and pegylated pheophorbide a against an amelanotic melanoma transplanted in C57/BL6 mice

scientific article

The duplex-hairpin conformational transition of d(CGCGCGATCGCGCG) and d(CGCGCGTACGCGCG): a thermodynamic and kinetic study

scientific article published on 01 August 1988

The effect of INA [(R)-1-O-(1-pyrenylmethyl)glycerol] insertions on the structure and biological activity of a G-quadruplex from a critical KRAS G-rich sequence.

scientific article published on January 2007

The left-handed Z-DNA conformation in oligodeoxynucleotides containing different amounts of AT base pairs: a far UV circular dichroism study

scientific article published on 01 June 1989

The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription

scientific article published on 20 November 2017

Transcription inhibition of oncogenic KRAS by a mutation-selective peptide nucleic acid conjugated to the PKKKRKV nuclear localization signal peptide.

scientific article

dC-dG alternating oligonucleotides: thermodynamic and kinetic aspects of the B-Z transformation

scientific article published on 01 February 1987

hnRNPA1/UP1 Unfolds <i>KRAS</i> G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression

scientific article published on 30 November 2021

“Clicking” Porphyrins to Magnetic Nanoparticles for Photodynamic Therapy

scientific article published on 23 October 2013

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