Search filters

List of works by Margaret E. Ackerman

A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis

scientific article published on 15 December 2014

A modular IgG-scFv bispecific antibody topology

scientific article

A multiplexed assay to detect antimicrobial peptides in biological fluids and cell secretions

scientific article published on 11 September 2013

A randomized phase 4 study of immunogenicity and safety following monovalent oral type 2 Sabin polio vaccine challenge in IPV-vaccinated children in Lithuania

scientific article published on 04 July 2020

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

scientific article

A33 antigen displays persistent surface expression

scientific article published on July 2008

Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 30 May 2016

Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge

scientific article published on 03 September 2020

An antibody tag-team: driving neutralization through escape

scientific article published on 15 August 2014

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

scientific article published on 10 March 2014

Analysis of complement-mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses in Rhesus macaques

article

Antibody Fab-Fc properties outperform titer in predictive models of SIV vaccine-induced protection

scientific article published on 02 May 2019

Antibody humanization by structure-based computational protein design.

scientific article

Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality

scientific article published on 18 December 2020

Antibody subclass skewing predicts enhanced ADCC activity in both natural infection and vaccination

scientific article

Antibody-mediated complement activation in pathology and protection

scientific article published on 06 March 2020

Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

scientific article published on 01 August 2018

Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses.

scientific article published on 13 December 2016

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

scientific article

Chimeric antigen receptors with human scFvs preferentially induce T cell anti-tumor activity against tumors with high B7H6 expression

scientific article published on 16 February 2018

Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge

scientific article published on 01 May 2020

Combinatorial resurfacing of Dengue envelope protein domain III antigens selectively ablates epitopes associated with serotype-specific or infection-enhancing antibody responses

scientific article published on 23 June 2020

Computationally-driven identification of antibody epitopes.

scientific article published on 4 December 2017

Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine

scientific article published on April 2016

Corrigendum to “A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples”

scholarly article published in Journal of Immunological Methods

Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals ⬇️

scientific article published on May 12, 2011

Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV.

scientific article published on 31 August 2016

Determining the Phagocytic Activity of Clinical Antibody Samples ⬇️

scientific article published on November 30, 2011

Development of unique cytotoxic chimeric antigen receptors based on human scFv targeting B7H6.

scientific article

Directed evolution of a yeast-displayed HIV-1 SOSIP gp140 spike protein toward improved expression and affinity for conformational antibodies

scientific article

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

scientific article

Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers

scientific article published on 18 December 2013

Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects

scientific article published on 9 November 2016

Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

scientific article

Emerging concepts on the role of innate immunity in the prevention and control of HIV infection

scientific article

Engineering broadly neutralizing antibodies for HIV prevention and therapy

scientific article published on 28 January 2016

Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for FcγR2a and FcγR2b ⬇️

scientific article published on March 6, 2013

Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells

scientific article published on 14 October 2015

Enrichment of high affinity subclasses and glycoforms from serum-derived IgG using FcγRs as affinity ligands

scientific article published on 8 January 2018

Erratum: Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 01 October 2016

Evidence that CD32a does not mark the HIV-1 latent reservoir.

scientific article published on 19 September 2018

Exploiting bias in a non-immune human antibody library to predict antigenicity ⬇️

scientific article published on September 9, 2011

Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women

scientific article published on 13 June 2019

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

scientific article published on 17 February 2016

Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody

scientific article published on 20 July 2020

Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals

scientific article published on 06 August 2020

Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site

scientific article published on 8 March 2018

Genetically engineered alginate lyase-PEG conjugates exhibit enhanced catalytic function and reduced immunoreactivity

scientific article

Going native: Direct high throughput screening of secreted full-length IgG antibodies against cell membrane proteins

scientific article published on 21 September 2017

HIV-antibody complexes enhance production of type I interferon by plasmacytoid dendritic cells

scientific article published on 30 October 2017

HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies.

scientific article published on 9 April 2018

High-resolution definition of humoral immune response correlates of effective immunity against HIV.

scientific article

High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis.

scientific article published on 14 September 2017

High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples

scientific article

Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display

scientific article

Highly parallel characterization of IgG Fc binding interactions.

scientific article published on July 2014

Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies

scientific article published on 24 February 2020

Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function

scientific article published on November 2014

IgG Binding Characteristics of Rhesus Macaque FcγR

scientific article published on 24 August 2016

IgG Fc glycosylation as an axis of humoral immunity in childhood

scientific article published on 24 October 2019

IgG Fc variant cross-reactivity between human and rhesus macaque FcγRs

scientific article published on 5 January 2017

IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees

scientific article published on 08 October 2020

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

scientific article published on 16 December 2019

Implementation of a three-tiered approach to identify and characterize anti-drug antibodies raised against HIV-specific broadly neutralizing antibodies

scientific article published on 15 February 2020

Increasing the Clinical Potential and Applications of Anti-HIV Antibodies

scientific article

Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection

scientific article published on 11 August 2014

Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity

scientific article published on 17 March 2020

Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs

scientific article published on 17 November 2017

Intestinal Immune Responses to Type 2 Oral Polio Vaccine (OPV) Challenge in Infants Previously Immunized With Bivalent OPV and Either High-Dose or Standard Inactivated Polio Vaccine.

scientific article published on 3 January 2018

Intestinal Immunity to Poliovirus Following Sequential Trivalent Inactivated Polio Vaccine/Bivalent Oral Polio Vaccine and Trivalent Inactivated Polio Vaccine-only Immunization Schedules: Analysis of an Open-label, Randomized, Controlled Trial in Chi

scientific article

Intestinal antibody responses to a live oral poliovirus vaccine challenge among adults previously immunized with inactivated polio vaccine in Sweden

scientific article published on 28 August 2019

Intestinal antibody responses to two novel live attenuated type 2 oral poliovirus vaccines in healthy adults in Belgium

scientific article published on 24 December 2020

Intestinal immunity is a determinant of clearance of poliovirus after oral vaccination

scientific article published on 23 January 2014

Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1

article

Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies

scientific article

Live attenuated and inactivated influenza vaccines in children

scientific article

Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains

scientific article published on 01 February 2020

Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees

scientific article

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

scientific article published on 01 July 2020

Mapping the Journey to an HIV Vaccine ⬇️

scientific article published on July 25, 2013

Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health

scientific article published on 25 February 2020

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity

scientific article published on 10 April 2019

Microscale purification of antigen-specific antibodies

scientific article

Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function

scientific article published on 08 April 2019

Mining for humoral correlates of HIV control and latent reservoir size

scientific article published on 13 October 2020

Mucosal Immunity: The Forgotten Arm of the Immune System: Synopsis of the Pediatric Infectious Disease Society's 2017 Stanley A. Plotkin Lecture in Vaccinology

scientific article published on 22 December 2017

Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles

scientific article published on 02 February 2017

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

scientific article published on 8 April 2013

Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?

scientific article published on 30 August 2018

Opportunities to exploit non-neutralizing HIV-specific antibody activity

scientific article published on July 2013

Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs

scientific article published on 07 January 2020

Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV.

scientific article published on 29 January 2018

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

scientific article

Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines

scientific article published on March 2014

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

scientific article published on 8 January 2016

Prospects for engineering HIV-specific antibodies for enhanced effector function and half-life

scientific article published on May 2015

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

scientific article

Protein-based, but not viral vector alone, HIV vaccine boosting drives an IgG1-biased polyfunctional humoral immune response

scientific article published on 18 June 2020

Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir

scientific article published in Nature

RV144 HIV-1 vaccination impacts post-infection antibody responses

scientific article published on 08 December 2020

Recent insights into Fc-mediated effector responses to HIV-1

scientific article published on 15 July 2020

Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

scientific article published on 12 October 2021

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

scientific article published on 03 September 2018

SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy

scientific article published on 18 September 2020

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study

scientific article published on 08 August 2019

Separation of nonfucosylated antibodies with immobilized FcγRIII receptors

scientific article

Stability and CDR composition biases enrich binder functionality landscapes

scientific article

Systems serology for decoding infection and vaccine-induced antibody responses to HIV-1

scientific article published on 01 July 2019

Systems serology for evaluation of HIV vaccine trials

scientific article

The role of Fc receptors in HIV prevention and therapy

scientific article

Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen.

scientific article published in April 2018

Tracking the Trajectory of Functional Humoral Immune Responses Following Acute HIV Infection

scientific article published on 07 August 2020

Vaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants

scientific article published on 13 September 2016

Vector induced skewing of antibody Fc-effector functions

What mAbs tell us about shapes: multiple roads lead to Rome

scientific article published on 01 January 2013

Yeast surface display of HIV Env protein variants for the discovery of novel vaccine immunogens

article

λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies

scientific article

Paulina is supported by:

About Paulina

Help