List of works - Ellen I Closs

A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.

scientific article

A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family

scientific article

A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes

scientific article published on 01 May 1992

Activation of classical protein kinase C decreases transport via systems y+ and y+L.

scientific article published on 28 February 2007

Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane

scientific article

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia

scientific article

Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2.

scientific article published on 24 September 2015

Big shoes to fill

scientific article

Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice.

scientific article

Cytokines and insulin induce cationic amino acid transporter (CAT) expression in cardiac myocytes. Regulation of L-arginine transport and no production by CAT-1, CAT-2A, and CAT-2B

scientific article published on 01 May 1996

Decoding the substrate supply to human neuronal nitric oxide synthase.

scientific article published on 9 July 2013

Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles.

scientific article published in January 2005

Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase.

scientific article published in September 2015

Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice

scientific article

Effects of leukemogenic retroviruses on condylar cartilage in vitro: an ultrastructural study.

scientific article published in January 1989

Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity

scientific article

Expression, regulation and function of carrier proteins for cationic amino acids.

scientific article

Failure of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to inhibit soluble guanylyl cyclase in rat ventricular cardiomyocytes.

scientific article

Gene expression during osteogenic differentiation in mandibular condyles in vitro ⬇️

scientific article published on April 1, 1990

Granulocyte functions are independent of arginine availability.

scientific article

Human cationic amino acid transporter gene hCAT-2 is assigned to 8p22 but is not the causative gene in lysinuric protein intolerance

scientific article published on 01 July 1997

Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues

scientific article (publication date: 16 October 2001)

Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders

scientific article

Identification of carrier systems in plasma membranes of mammalian cells involved in transport of L-arginine

scientific article published on 01 January 1999

Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.

scientific article published on 9 September 2013

Impairment of the extrusion transporter for asymmetric dimethyl-l-arginine: A novel mechanism underlying vasospastic angina ⬇️

scientific article published on May 15, 2012

In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function

scientific article

Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation

scientific article published on 9 October 2015

Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells.

scientific article published on 21 November 2006

Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B.

scientific article published on February 1997

Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.

scientific article published on October 1995

Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.

scientific article published on 18 December 2017

Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.

scientific article

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

scientific article

Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3

scientific article (publication date: March 2005)

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

scientific article

OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1)

scientific article

Paradoxical effect of L-arginine: acceleration of endothelial cell senescence.

scientific article published on 21 June 2009

Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

scientific article

Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity.

scientific article

Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1.

scientific article

Putative role of cationic amino acid transporter-3 in murine liver metabolism.

scientific article published on 24 February 2015

Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

scientific article published on 24 July 2017

Regulation of cationic amino acid transport: the story of the CAT-1 transporter.

scientific article published in January 2004

Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1.

scientific article published on 25 March 2004

Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase ⬇️

scientific article published on August 2, 2011

Relief of microRNA-mediated translational repression in human cells subjected to stress

scientific article (publication date: 16 June 2006)

Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.

scientific article published on 7 July 2010

Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells.

scientific article published on 25 September 2003

Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide ⬇️

scientific article published on September 1, 2003

Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells.

scientific article published on January 2006

System L amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-L-tyrosine (FET).

scientific article

The transport activity of the human cationic amino acid transporter hCAT-1 is downregulated by activation of protein kinase C

scientific article

Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells.

scientific article published on November 1999

Transport of cationic amino acids by the mouse ecotropic retrovirus receptor.

scientific article

Transport of peptides, amino acids, and derivatives

scientific article published on 01 September 2006

Two amino acid residues determine the low substrate affinity of human cationic amino acid transporter-2A.

scientific article published on 12 March 2003

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice.

scientific article published on 19 November 2015

List of works by Ellen I Closs

A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.

A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family

A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes

Activation of classical protein kinase C decreases transport via systems y+ and y+L.

Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia

Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2.

Big shoes to fill

Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice.

Cytokines and insulin induce cationic amino acid transporter (CAT) expression in cardiac myocytes. Regulation of L-arginine transport and no production by CAT-1, CAT-2A, and CAT-2B

Decoding the substrate supply to human neuronal nitric oxide synthase.

Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles.

Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase.

Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice

Effects of leukemogenic retroviruses on condylar cartilage in vitro: an ultrastructural study.

Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity

Expression, regulation and function of carrier proteins for cationic amino acids.

Failure of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to inhibit soluble guanylyl cyclase in rat ventricular cardiomyocytes.

Gene expression during osteogenic differentiation in mandibular condyles in vitro ⬇️

Granulocyte functions are independent of arginine availability.

Human cationic amino acid transporter gene hCAT-2 is assigned to 8p22 but is not the causative gene in lysinuric protein intolerance

Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues

Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders

Identification of carrier systems in plasma membranes of mammalian cells involved in transport of L-arginine

Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.

Impairment of the extrusion transporter for asymmetric dimethyl-l-arginine: A novel mechanism underlying vasospastic angina ⬇️

In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function

Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation

Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells.

Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B.

Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.

Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.

Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1)

Paradoxical effect of L-arginine: acceleration of endothelial cell senescence.

Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity.

Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1.

Putative role of cationic amino acid transporter-3 in murine liver metabolism.

Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

Regulation of cationic amino acid transport: the story of the CAT-1 transporter.

Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1.

Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase ⬇️

Relief of microRNA-mediated translational repression in human cells subjected to stress

Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.

Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells.

Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide ⬇️

Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells.

System L amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-L-tyrosine (FET).

The transport activity of the human cationic amino acid transporter hCAT-1 is downregulated by activation of protein kinase C

Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells.

Transport of cationic amino acids by the mouse ecotropic retrovirus receptor.

Transport of peptides, amino acids, and derivatives

Two amino acid residues determine the low substrate affinity of human cationic amino acid transporter-2A.

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice.