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List of works by Shuguang Yuan

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

scientific article published on 19 January 2018

Action of molecular switches in GPCRs--theoretical and experimental studies.

scientific article

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

scientific article published on 30 January 2020

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

scientific article published on 09 September 2014

Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2

scientific article published on 11 November 2020

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

scientific article published on 23 April 2019

Correction to "Investigating Substrate Scope and Enantioselectivity of a Defluorinase by a Stereochemical Probe".

scientific article

Designing Safer Analgesics via μ-Opioid Receptor Pathways

scientific article published on 18 September 2017

Development of Photoaffinity Probe for the Discovery of Steviol Glycosides Biosynthesis Pathway in Stevia rebuadiana and Rapid Substrate Screening

scientific article published on 12 June 2018

Discovery of Arabidopsis UGT73C1 as a steviol-catalyzing UDP-glycosyltransferase with chemical probes

scientific article published on 01 June 2018

Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates

scientific article

Enhancing the Signaling of GPCRs via Orthosteric Ions

scientific article published on 23 January 2020

Enhancing the production of galacto-oligosaccharides by mutagenesis of Sulfolobus solfataricus β-galactosidase

scientific article published on 19 November 2012

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

scientific article

Exploring a new ligand binding site of G protein-coupled receptors

GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection.

scientific article published on 14 November 2017

Hatchet ribozyme structure and implications for cleavage mechanism

scientific article published on 14 May 2019

Implementing WebGL and HTML5 in Macromolecular Visualization and Modern Computer-Aided Drug Design

scientific article published on 13 April 2017

Investigating Substrate Scope and Enantioselectivity of a Defluorinase by a Stereochemical Probe.

scientific article published on 25 July 2017

Large conformational changes of a highly dynamic pre-protein binding domain in SecA

scientific article published on 03 September 2018

Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations

scientific article (publication date: 2013)

Mechanistic study of the radical SAM-dependent amine dehydrogenation reactions

scientific article

Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII

scientific article

Movements of the Substrate-Binding Clamp of Cypemycin Decarboxylase CypD

scientific article published on 29 April 2019

New Binding Sites, New Opportunities for GPCR Drug Discovery

scientific article published on 03 January 2019

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

scientific article published in Nature

Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.

scientific article published on 12 December 2017

Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family

scientific article

The Molecular Mechanism of P2Y1 Receptor Activation

scientific article published on 27 July 2016

The Principles of Ligand Specificity on beta-2-adrenergic receptor

scientific article (publication date: 5 October 2016)

The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors.

scientific article published on 12 May 2015

The role of water and sodium ions in the activation of the μ-opioid receptor

scientific article

The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations

scientific article

W246(6.48) opens a gate for a continuous intrinsic water pathway during activation of the adenosine A2A receptor

scientific article published on 17 November 2014

pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity?

scientific article

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