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List of works by Brian P Mahon

A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

scientific article

Active-site solvent replenishment observed during human carbonic anhydrase II catalysis

scientific article published in January 2018

Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.

scientific article published on 6 May 2015

Carbonic Anhydrases: Role in pH Control and Cancer.

scientific article published on 28 February 2018

Carbonic anhydrase II microcrystals suitable for XFEL studies

scientific article published on 17 May 2018

Crystal Structure of Cleaved Serp-1, a Myxomavirus-derived Immune Modulating Serpin; Structural Design of Serpin Reactive Center Loop (RCL) Peptides with Improved Therapeutic Function.

scientific article published on 11 December 2017

Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency

scientific article

Effects of Hinge Region Natural Polymorphisms on Human Immunodeficiency Virus-1 Protease Structure, Dynamics and Drug-Pressure Evolution

scientific article

Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.

scientific article published on 31 July 2017

Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111

scientific article published on 11 January 2016

Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli.

scientific article published on 12 August 2015

Probing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitors

scientific article

Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.

scientific article

Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration

scientific article

Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates

scientific article

Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.

scientific article published on 19 March 2017

Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity

scientific article published on 18 November 2016

Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA

scientific article published on 01 December 2015

Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy?

scientific article

Targeting carbonic anhydrase IX activity and expression.

scientific article

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