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List of works by Frank Brombacher

A cross-reactive monoclonal antibody to nematode haemoglobin enhances protective immune responses to Nippostrongylus brasiliensis

scientific article

A promoter-level mammalian expression atlas

scientific article

Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness

scientific article

BALB/c Mice Deficient in CD4+ T Cell IL-4Rα Expression Control Leishmania mexicana Load although Female but Not Male Mice Develop a Healer Phenotype ⬇️

scientific article published on January 4, 2011

Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection

scientific article

Can We Harness Immune Responses to Improve Drug Treatment in Leishmaniasis?

scientific article published on 17 July 2020

Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases helminth-associated pathology in a mouse model

article

Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice

scientific article

Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection.

scientific article

Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

scientific article

Deletion of IL-4Rα signalling on B cells limits hyperresponsiveness depending on antigen-load

scientific article published on 28 December 2020

Dendritic Cell-Mediated Vaccination Relies on Interleukin-4 Receptor Signaling to Avoid Tissue Damage after Leishmania major Infection of BALB/c Mice ⬇️

scientific article published on July 3, 2012

Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages.

scientific article

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

scientific article published on January 2013

Endogenous IL-13 Plays a Crucial Role in Liver Granuloma Maturation During Leishmania donovani Infection, Independent of IL-4Rα–Responsive Macrophages and Neutrophils ⬇️

scientific article published on July 1, 2011

Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis.

scientific article

Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.

scientific article

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha

scientific article

IL-25 regulates Th17 function in autoimmune inflammation

scientific article

IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis

scientific article published on 17 January 2020

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

scientific article published on 07 October 2013

IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness

scientific article

IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection

scientific article

IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice

scientific article (publication date: 2015)

IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins

scientific article

Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses

scientific article

Infection stage-dependent modulation of macrophage activation in Trypanosoma congolense-resistant and -susceptible mice

scientific article

Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences ovalbumin-induced allergic reactions

scientific article

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

scientific article

Interleukin-17 is a negative regulator of established allergic asthma

scientific article

Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection.

scientific article

Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection

scientific article

Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice

scientific article

Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma

scientific article

Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells.

scientific article

NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia

scientific article published on 12 June 2015

Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis

scientific article

Nippostrongylus-induced intestinal hypercontractility requires IL-4 receptor alpha-responsiveness by T cells in mice

scientific article

Novel IL-12 family members shed light on the orchestration of Th1 responses

scientific article

Omega-3 Fatty Acid and Iron Supplementation Alone, but Not in Combination, Lower Inflammation and Anemia of Infection in Mycobacterium tuberculosis-Infected Mice

scientific article published on 22 September 2020

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

scientific article published on 29 May 2019

Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes.

scholarly article

Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics.

scientific article

Role of IL-4Rα during acute schistosomiasis in mice

scientific article

Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice ⬇️

scientific article published on April 4, 2011

Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape

scientific article

Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis

scientific article published in PLoS ONE

Surfactant Protein-D Is Essential for Immunity to Helminth Infection.

scientific article

Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity

scientific journal article

T Helper1/T Helper2 Cells and Resistance/Susceptibility to Leishmania Infection: Is This Paradigm Still Relevant? ⬇️

scientific article published on April 17, 2012

TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis

scientific article published on November 2006

The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection

scientific article

The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

scientific article

The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice

scientific article

The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model

scientific article

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

scientific article

Therapeutic and prophylactic deletion of IL-4Rα signaling ameliorates established ovalbumin-induced allergic asthma

scientific article published on 29 November 2019

Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion. ⬇️

scientific article

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

scientific article

Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages.

scientific article

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

scientific article

mTOR inhibition rescues osteopenia in mice with systemic sclerosis

scientific article

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