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List of works by Xiaodong Cheng

A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP.

scientific article published on 24 July 2017

Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes.

scientific article

Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology

scientific article published on 21 December 2019

Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase

scientific article published on 14 October 2020

Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase

scientific article published on 10 August 2020

Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosis Development

scientific article published on 15 October 2020

Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates

scientific article published on 20 April 2022

Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling

scientific article published on 01 January 2020

Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics

scientific article

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.

scientific article published in April 2018

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

scientific article published on 19 November 2019

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).

scientific article published on 25 October 2017

β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion

scientific article published on 11 June 2019

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