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List of works by Colin Farquharson

A cell shrinkage artefact in growth plate chondrocytes with common fixative solutions: importance of fixative osmolarity for maintaining morphology.

scientific article published on 14 May 2010

A comparison of the bone and growth phenotype of mdx, mdx:Cmah-/- and mdx:Utrn +/- murine models with the C57BL/10 wild-type mouse

scientific article published on 10 January 2020

A distinctive patchy osteomalacia characterises Phospho1-deficient mice.

scientific article

A guide to modern quantitative fluorescent western blotting with troubleshooting strategies

scientific article

A novel integral membrane protein is differentially expressed in the chick growth plate and maps to chromosome 1.

scientific article published in August 1999

A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

scientific article published on 21 March 2013

Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.

scientific article

Alterations in glycosaminoglycan concentration and sulfation during chondrocyte maturation.

scientific article published in April 1994

Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice

scientific article

An investigation of the mineral in ductile and brittle cortical mouse bone

scientific article published in May 2015

Animal models to explore the effects of glucocorticoids on skeletal growth and structure

scientific article published on 19 October 2017

Ascorbic acid-induced chondrocyte terminal differentiation: the role of the extracellular matrix and 1,25-dihydroxyvitamin D.

scientific article

Avian tibial dyschondroplasia: The interaction of genetic selection and dietary 1,25 ‐dihydroxycholecalciferol

scientific article published on 01 June 1993

Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease

scientific article published on 03 December 2019

BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway

scientific article published on 9 October 2014

Bone strength during growth: influence of growth rate on cortical porosity and mineralization.

scientific article published on 25 September 2003

Cartilage development and degeneration: a Wnt Wnt situation

scientific article published on 19 June 2012

Cartilage to bone transitions in health and disease

scientific article

Cell proliferation and enzyme activities associated with the development of avian tibial dyschondroplasia: an in situ biochemical study.

scientific article

Cell proliferation within the growth plate of long bones assessed by bromodeoxyuridine uptake and its relationship to glucose 6-phosphate dehydrogenase activity

scientific article published in August 1990

Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.

scientific article published on November 2006

Characterisation of matrix vesicles in skeletal and soft tissue mineralisation

scientific article

Chondrocyte p21(WAF1/CIP1) expression is increased by dexamethasone but does not contribute to dexamethasone-induced growth retardation in vivo

scientific article

Chondrocytes and longitudinal bone growth: the development of tibial dyschondroplasia.

scientific article published in July 2000

Chondrogenic ATDC5 cells: an optimised model for rapid and physiological matrix mineralisation

scientific article published on 31 August 2012

Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene

scientific article published in December 2002

Cloning differentially regulated genes from chondrocytes using agarose gel differential display

scientific article

Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily.

scientific article

Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization

scientific article published on 21 May 2013

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity

scientific article published on 01 January 2020

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

scientific article published on 27 July 2019

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

scientific article

Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases (review).

scientific article published on December 2006

Cytokine profiling and in vitro studies of murine bone growth using biological fluids from children with juvenile idiopathic arthritis.

scientific article

Deer Antler Does Not Represent a Typical Endochondral Growth System: Immunoidentification of Collagen Type X but Little Collagen Type II in Growing Antler Tissue

scientific article published on 01 October 1997

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

scientific article

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.

scientific article

Determining broiler bone life history

Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.

scientific article

Dietary Ca and P requirements and skeletal quality in broiler chickens

scientific article published on 01 December 1999

Dietary effects on bone quality and turnover, and Ca and P metabolism in chickens

scientific article published on 01 August 2000

Differences in metabolic parameters and gene expression related to osteochondrosis/osteoarthrosis in pigs fed 25-hydroxyvitamin D3.

scientific article published in July 2002

Differentiation and mineralization in chick chondrocytes maintained in a high cell density culture: a model for endochondral ossification.

scientific article

Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- mice

scientific article

Distribution and quantification of pyridinium cross-links of collagen within the different maturational zones of the chick growth plate.

scientific article published in August 1996

Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues

scientific article published on 26 December 2016

E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models

scientific article published on 7 December 2015

Effects of choice of reverse-transcriptase enzyme and use of T4 gene 32 protein on banding patterns in agarose gel differential display.

scientific article

Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes.

scientific article published on February 2006

End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.

scientific article published on 30 March 2017

Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model

scientific article published on 25 November 2015

Endocrine role of bone: recent and emerging perspectives beyond osteocalcin

scientific article

Endogenous mediators of growth

scientific article published on October 1990

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis

Evidence of ultracytochemical mitochondria-derived hydrogen peroxide activity in myocardial cells from broiler chickens with an ascites syndrome

article

Excretion of pyridinium cross-links of collagen in ovariectomized rats as urinary markers for increased bone resorption

scientific article published on 01 May 1989

Exploiting novel valve interstitial cell lines to study calcific aortic valve disease.

scientific article published on 27 November 2017

Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.

scientific article published on 14 October 2015

Expression of type X collagen, Indian hedgehog and parathyroid hormone related-protein in normal and tibial dyschondroplastic chick growth plates.

scientific article published on February 2003

Expression patterns of candidate genes for tibial dyschondroplasia in chicken growth plate chondrocytes separated on percoll density gradients.

scientific article published in December 1998

Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia

scientific article published in June 2000

Extracellular fatty acid binding protein (Ex-FABP) modulation by inflammatory agents: ?physiological? acute phase response in endochondral bone formation

scientific article published on 01 March 2000

Extracellular matrix mineralization promotes E11/gp38 glycoprotein expression and drives osteocytic differentiation

scientific article

FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression

scientific article published on 7 December 2017

Female rats are susceptible to cardiac hypertrophy induced by copper deficiency: the lack of influence of estrogen and testosterone.

scientific article

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.

scientific article published in April 2007

Further Observations on Programmed Cell Death in the Epiphyseal Growth Plate: Comparison of Normal and Dyschondroplastic Epiphyses

scientific article published on 01 October 1997

Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading.

scientific article published on 3 May 2009

Glucocorticoid effects on chondrogenesis, differentiation and apoptosis in the murine ATDC5 chondrocyte cell line

scientific article published on December 2002

Growth and the Growth Hormone-Insulin Like Growth Factor 1 Axis in Children With Chronic Inflammation: Current Evidence, Gaps in Knowledge, and Future Directions.

scientific article published on 31 December 2015

Growth hormone and longitudinal bone growth in vivo: short-term effect of a growth hormone antiserum.

scientific article published in July 1995

Growth plate chondrocyte vitamin D receptor number and affinity are reduced in avian tibial dyschondroplastic lesions

scientific article published on 01 August 1996

How To Build a Bone: PHOSPHO1, Biomineralization, and Beyond

scientific article published on 07 July 2019

Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities

scientific journal article

Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation

scientific article published on 10 May 2017

IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta.

scientific article

Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes.

scientific article

Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6.

scientific article

Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes

scientific article published in January 2005

Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1.

scientific article

Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling ⬇️

scientific article published on August 8, 2013

Immunohistochemical localization of native and denatured collagen types I and II in fetal and adult rat long bones

scientific article published on 01 January 1988

Immunolocalization of collagen types I and III in the arterial wall of the rat

scientific article published on 01 March 1989

Immunolocalization of collagen types I, III and IV, elastin and fibronectin within the heart of normal and copper-deficient rats

scientific article published in April 1991

In vivo and in vitro effect of 1,25-dihydroxyvitamin D3 and 1,25-dihydroxy-16-ene-23-yne-vitamin D3 on the proliferation and differentiation of avian chondrocytes: their role in tibial dyschondroplasia

scientific article published on 01 March 1996

In vivo effect of 1,25-dihydroxycholecalciferol on the proliferation and differentiation of avian chondrocytes

scientific article published on 01 September 1993

Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice.

scientific article published in February 2009

Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.

scientific article published on November 2015

Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling.

scientific article published on 11 August 2012

Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth.

scientific article published on April 2009

Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick

scientific article

Insulin-like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid-mediated growth retardation in fetal mice metatarsal cultures.

scientific article published on 28 January 2004

Interaction between dietary 1,25‐dihydroxycholecalciferol and calcium and effects of management on the occurrence of tibial dyschondroplasia, leg abnormalities and performance in broiler chickens

scientific article published on 01 July 1995

Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation

scientific article

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification.

scientific article published on 20 November 2017

Kidney lesions in copper-deficient rats

scientific article published on 01 March 1987

Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles

scientific article

Localisation and expression of TRPV6 in all intestinal segments and kidney of laying hens.

scientific article

Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification

scientific journal article

MEPE is a novel regulator of growth plate cartilage mineralization

scientific journal article

MMP and TIMP temporal gene expression during osteocytogenesis.

scientific article published on 14 May 2015

Mechanisms and clinical consequences of vascular calcification

scientific article

Microtubules are potential regulators of growth-plate chondrocyte differentiation and hypertrophy

scientific article published on 01 October 1999

Mitogenic action of insulin-like growth factor-I on human osteosarcoma MG-63 cells and rat osteoblasts maintained in situ: the role of glucose-6-phosphate dehydrogenase

scientific article published on August 1993

Observations on the pancreas of cattle deficient in copper

scientific article published on 01 October 1985

Optimised isolation method for RNA extraction suitable for RNA sequencing from feline teeth collected in a clinical setting and at post mortem

scientific article published on 06 November 2018

PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures

scientific journal article

PHOSPHO1 is essential for normal bone fracture healing: An Animal Study

scientific article published on 01 June 2018

PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage.

scientific article published on April 2004

PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization.

scientific article published on September 2017

Parathyroid hormone-related peptide expression in tibial dyschondroplasia

scientific article

Pathophysiology and management of abnormal growth in children with chronic inflammatory bowel disease.

scientific article published on 11 February 2013

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

scientific article published on January 2013

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing

scientific article

Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues

scientific article published on 30 August 2007

Piroxicam treatment augments bone abnormalities in interleukin-10 knockout mice.

scientific article published in February 2015

Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2.

scientific article published on August 2005

Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization

scientific article published on 16 April 2019

Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness

scientific article published on October 2014

Regulation of chondrocyte terminal differentiation in the postembryonic growth plate: the role of the PTHrP-Indian hedgehog axis

scientific article published in September 2001

Regulators of chondrocyte differentiation in tibial dyschondroplasia: an in vivo and in vitro study

scientific article

Role of PHOSPHO1 in Periodontal Development and Function

scientific article

SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis

scientific article

Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.

scientific article published on 15 January 2016

Skeletal development in the meat-type chicken.

scientific article published in May 2000

Skeletal energy homeostasis: a paradigm of endocrine discovery

scientific article

Social networking between cells of the foetal skeleton: the importance of thyroid hormones

scientific article published on 16 June 2011

Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells.

scientific article published on 17 June 2011

Studies on growth plate chondrocytes in situ: cell proliferation and differentiation

scientific article

Suppression of mammalian bone growth by membrane transport inhibitors.

scientific article

Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.

scientific article published on 17 January 2018

The Ex Vivo Organ Culture of Bone

scientific article published on 01 January 2019

The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures

scientific article published on 21 July 2016

The Functional co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 during initiation of Skeletal Mineralization.

scientific article

The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells

scientific article

The control of chondrocyte differentiation during endochondral bone growth in vivo: changes in TGF-beta and the proto-oncogene c-myc

scientific article published on 01 August 1993

The distribution of elastin in developing and adult rat organs using immunocytochemical techniques.

scientific article

The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins.

scientific article published on 14 July 2010

The effects of copper deficiency on the pyridinium crosslinks of mature collagen in the rat skeleton and cardiovascular system

scientific article published on 01 November 1989

The effects of reserpine upon the cardiac enlargement of copper deficiency

The expression of transforming growth factor-beta by cultured chick growth plate chondrocytes: differential regulation by 1,25-dihydroxyvitamin D3.

scientific article published in May 1996

The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438.

scientific article published on 19 December 2006

The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling ⬇️

scientific article published on June 13, 2012

The pathophysiology of the growth plate in juvenile idiopathic arthritis

scientific article

The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization

scientific journal article

The proto-oncogene C-myc is involved in cell differentiation as well as cell proliferation: Studies on growth plate chondrocytes in situ

scientific article published on 01 July 1992

The restricted potential for recovery of growth plate chondrogenesis and longitudinal bone growth following exposure to pro-inflammatory cytokines.

scientific article published on May 2006

The role of sex steroids in controlling pubertal growth

scientific article published on 20 July 2007

The skeleton: no bones about it ⬇️

scientific article published on July 22, 2011

Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting

scientific article

Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption

scientific article published on 03 November 2020

Upregulation of IGF2 expression during vascular calcification

scientific article published on 30 January 2014

Visualisation and selective elimination of a subpopulation of mitogen-responsive bone marrow stromal cells using bromodeoxyuridine and photo-induced cell killing

scientific article published on 01 September 1993

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