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List of works by Paul M Yen

9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors.

scientific article

A case of spurious hypercalcitoninemia: a cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia.

scientific article published in May 2001

A clinician's guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms.

scientific article published on 15 September 2017

A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy.

scientific article

Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance

scientific article (publication date: September 2001)

Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease

scientific article published on 21 January 2014

An Inhibitory Region of the DNA-Binding Domain of Thyroid Hormone Receptor Blocks Hormone-Dependent Transactivation ⬇️

scientific article published on January 1, 1998

An integrative approach identified genes associated with drug response in gastric cancer.

scientific article

Anti-estrogenic compounds increase prolactin and growth hormone synthesis in clonal strains of rat pituitary cells

scientific article published on October 1, 1977

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.

scientific article published on 18 February 2014

Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity

scientific article published on 6 February 2004

Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.

scientific article published on 29 April 2017

Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging.

scientific article published on 26 February 2017

Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors

scientific article published on 01 September 1993

Classical nuclear hormone receptor activity as a mediator of complex biological responses: a look at health and disease.

scientific article published on 16 July 2015

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism

scientific article published on 04 March 2014

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.

scientific article published on March 2014

Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors

scientific article

Corrigendum to "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells" [Biochem. Biophys. Res. Commun. 480 (2016) 461-467]

scientific article published on 26 November 2016

Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice

scientific article published on 11 February 2016

Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.

scientific article published on 13 April 2014

Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells.

scientific article published on August 1994

Direct effects of thyroid hormones on hepatic lipid metabolism.

scientific article

Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors? ⬇️

scientific article published on November 1, 1995

Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism

scientific article

Dynamic shuttling and intranuclear mobility of nuclear hormone receptors.

scientific article

Editorial: studying hormonal regulation by microarrays: distinguishing the trees from the forest

scientific article published on 01 February 2005

Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice.

scientific article

Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance.

scientific article published on 29 January 2014

Expression and Hormonal Regulation of Coactivator and Corepressor Genes ⬇️

scientific article published on May 1, 1998

Factors that enhance Escherichia coli-expressed TR beta binding to T3 and DNA

scientific article published on 01 August 1995

Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library

scientific article

Germline and somatic thyroid hormone receptor mutations in man.

scientific article published on August 2003

Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport.

scientific article

Graves' disease after interleukin-2 therapy in a patient with human immunodeficiency virus infection

scientific article published in December 2004

Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition

scientific article

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity

scientific article published on 17 September 2016

Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa).

scientific article published on 20 March 2017

Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation

scientific article published on 08 December 2016

Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy

scientific article published on 25 October 2017

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency

scientific article published on 10 October 2015

Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE.

scientific article published on October 1997

Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor alpha by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action

scientific article published on 01 December 1998

Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland

scientific article published on 01 April 1995

Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene

scientific article

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells

scientific article

Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet.

scientific article

Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.

scientific article published in February 2003

Molecular basis of resistance to thyroid hormone.

scientific article

Molecular mechanisms of dominant negative activity by nuclear hormone receptors.

scientific article published on November 1994

Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription

scientific article published on 01 February 1997

Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation

scientific article published on 05 February 2009

New insights into thyroid hormone action.

scientific article published on June 2007

New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone.

scientific article published on November 1992

PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA.

scientific article published on 12 August 2013

Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro.

scientific article

Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease.

scientific article published on 27 July 2016

Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis

scientific article published on 30 November 2016

Recombinant human thyrotropin for the diagnosis and treatment of a highly functional metastatic struma ovarii

scientific article published on 01 January 2000

Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization.

scientific article

Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia.

scientific article published in September 2017

Resistance to thyroid hormone in a patient without thyroid hormone receptor mutations.

scientific article published on January 2002

Resveratrol induces insulin gene expression in mouse pancreatic α-cells.

scientific article published on 13 December 2013

Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes.

scientific article

Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy.

scientific article published on 16 February 2017

Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation

scientific article published on 01 March 1994

Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells.

scientific article published in July 1981

Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells.

scientific article

Species Differences in Cardiac Thyroid Hormone Receptor Isoforms Protein Abundance ⬇️

scientific article published on November 1, 1997

Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism.

scientific article published on 19 March 2014

Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants

scientific article published on 01 July 1995

T3 or not T3--the slings and arrows of outrageous TR function

scientific article published on 01 February 1996

TSHβv-A New Bone to Pick.

scientific article

The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts

scientific article published on 01 May 1996

The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions

scientific article published on 11 January 2007

Thyroid Hormone Response Elements Differentially Modulate the Interactions of Thyroid Hormone Receptors with Two Receptor Binding Domains in the Steroid Receptor Coactivator-1 ⬇️

scientific article published on August 21, 1998

Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature.

scientific article published in May 2017

Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.

scientific article published on 12 November 2015

Thyroid disorders, noncommunicable diseases that gravely impact public health: a commentary and statement by the Advisory Board of the World Thyroid Federation

scientific article published on 01 June 2012

Thyroid hormone action at the cellular, genomic and target gene levels.

scientific article

Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling

scientific journal article

Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells

scientific article published on 5 October 2013

Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray.

scholarly article

Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism

scientific article

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy ⬇️

scientific article published on June 11, 2012

Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD

scientific article

Thyroid hormones and 3,5-diiodothyropropionic acid: new keys for new locks

scientific article published on 01 April 2006

Transgenic targeting of a dominant negative corepressor to liver blocks basal repression by thyroid hormone receptor and increases cell proliferation

scientific journal article

Unliganded TRs regulate growth and developmental timing during early embryogenesis: evidence for a dual function mechanism of TR action

scientific article published on 2 March 2015

Waterboarding is not torture: a physician's response

scientific article published on 01 May 2008

p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription

scientific article

β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver

scientific article

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