List of works - Luisa Iommarini

A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma

scientific article published on 11 December 2019

A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.

scientific article published on 24 February 2011

A comprehensive characterization of mitochondrial DNA mutations in glioblastoma multiforme

scientific article published on 7 February 2015

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.

scientific article

A novel in-frame 18-bp microdeletion in MT-CYB causes a multisystem disorder with prominent exercise intolerance

scientific article published on 28 June 2014

A unique combination of rare mitochondrial ribosomal RNA variants affects the kinetics of complex I assembly

scientific article published on 18 April 2016

An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells

scientific article

Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I.

scientific article published on 18 March 2014

Association of optic disc size with development and prognosis of Leber's hereditary optic neuropathy.

scientific article published on 20 December 2008

Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

scientific article

Complex I impairment in mitochondrial diseases and cancer: parallel roads leading to different outcomes

scientific article published on 02 June 2012

Cybrid studies establish the causal link between the mtDNA m.3890G>A/MT-ND1 mutation and optic atrophy with bilateral brainstem lesions

scientific article published on 14 December 2012

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment

scientific article published on 24 October 2013

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

scholarly article

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy

scientific article

Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.

scientific article published on 13 June 2013

Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways

scientific article

Haplogroup J mitogenomes are the most sensitive to the pesticide rotenone: Relevance for human diseases.

scientific article published on 24 February 2018

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

article

Mild phenotypes and proper supercomplex assembly in human cells carrying the homoplasmic m.15557G > A mutation in cytochrome b gene

scientific article

Mitochondrial Diseases Part I: mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors

scientific article

Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function

scientific article published on 29 January 2015

Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies

scientific article published on 29 January 2015

Mitochondrial metabolism and energy sensing in tumor progression

scientific article published on 14 February 2017

Mitochondrial optic neuropathies: how two genomes may kill the same cell type?

scientific article published on June 2007

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

scientific article published on 27 November 2017

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

scientific article

PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.

scientific article published on 18 March 2009

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

scientific article published on 11 October 2017

Peculiar combinations of individually non-pathogenic missense mitochondrial DNA variants cause low penetrance Leber's hereditary optic neuropathy

scientific article published on 14 February 2018

Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization.

scientific article published on 9 May 2017

Rare mtDNA variants in Leber hereditary optic neuropathy families with recurrence of myoclonus.

scientific article published on 23 January 2008

Rare primary mitochondrial DNA mutations and probable synergistic variants in Leber's hereditary optic neuropathy

scientific article

Revisiting the issue of mitochondrial DNA content in optic mitochondriopathies

Syndromic parkinsonism and dementia associated with OPA1 missense mutations

scientific article

Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy.

scientific article published on 26 September 2015

Targeting respiratory complex I to prevent the Warburg effect

scientific article

The Oncojanus Paradigm of Respiratory Complex I.

scientific article

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

scientific article

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity

scientific article

The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes

scientific article published on 14 February 2013

Tuning Cysteine Reactivity and Sulfenic Acid Stability by Protein Microenvironment in Glyceraldehyde-3-Phosphate Dehydrogenases of Arabidopsis thaliana

scientific article published on 01 February 2016

Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization.

scientific article published on 7 March 2018

List of works by Luisa Iommarini

A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma

A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.

A comprehensive characterization of mitochondrial DNA mutations in glioblastoma multiforme

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.

A novel in-frame 18-bp microdeletion in MT-CYB causes a multisystem disorder with prominent exercise intolerance

A unique combination of rare mitochondrial ribosomal RNA variants affects the kinetics of complex I assembly

An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells

Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I.

Association of optic disc size with development and prognosis of Leber's hereditary optic neuropathy.

Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

Complex I impairment in mitochondrial diseases and cancer: parallel roads leading to different outcomes

Cybrid studies establish the causal link between the mtDNA m.3890G>A/MT-ND1 mutation and optic atrophy with bilateral brainstem lesions

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy

Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.

Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways

Haplogroup J mitogenomes are the most sensitive to the pesticide rotenone: Relevance for human diseases.

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Mild phenotypes and proper supercomplex assembly in human cells carrying the homoplasmic m.15557G > A mutation in cytochrome b gene

Mitochondrial Diseases Part I: mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors

Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function

Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies

Mitochondrial metabolism and energy sensing in tumor progression

Mitochondrial optic neuropathies: how two genomes may kill the same cell type?

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

Peculiar combinations of individually non-pathogenic missense mitochondrial DNA variants cause low penetrance Leber's hereditary optic neuropathy

Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization.

Rare mtDNA variants in Leber hereditary optic neuropathy families with recurrence of myoclonus.

Rare primary mitochondrial DNA mutations and probable synergistic variants in Leber's hereditary optic neuropathy

Revisiting the issue of mitochondrial DNA content in optic mitochondriopathies

Syndromic parkinsonism and dementia associated with OPA1 missense mutations

Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy.

Targeting respiratory complex I to prevent the Warburg effect

The Oncojanus Paradigm of Respiratory Complex I.

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity

The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes

Tuning Cysteine Reactivity and Sulfenic Acid Stability by Protein Microenvironment in Glyceraldehyde-3-Phosphate Dehydrogenases of Arabidopsis thaliana

Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization.