List of works - Hiroaki Itoh

Antibody-mediated functional control of a dansylated polytheonamide mimic.

scientific article published on January 2014

Biological Effects of a Simplified Synthetic Analogue of Ion-Channel-Forming Polytheonamide B on Plasma Membrane and Lysosomes

scientific article published on 25 October 2019

Chemical construction and structural permutation of potent cytotoxin polytheonamide B: discovery of artificial peptides with distinct functions.

scientific article published on 14 March 2013

Comprehensive Structure-Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses

scientific article published on 04 April 2019

Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR

scientific article published on 14 October 2020

Design, synthesis and functional analysis of dansylated polytheonamide mimic: an artificial peptide ion channel.

scientific article

Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system.

scientific article published on 8 March 2018

Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

scientific article published on 05 July 2019

Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

scientific article published on 01 October 2020

Dual Chemical Modification of a Polytheonamide Mimic: Rational Design and Synthesis of Ion-Channel-Forming 48-mer Peptides with Potent Cytotoxicity

scientific article published on 02 February 2016

Full solid-phase total synthesis of macrocyclic natural peptides using four-dimensionally orthogonal protective groups

scientific article published on 24 June 2019

Phospholipid-Dependent Functions of a Macrocyclic Analogue of the Ion-Channel-Forming Antibiotic Gramicidin A

scientific article published on 01 January 2020

Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B

scientific article published on 07 August 2018

Solid-Phase Total Synthesis of Yaku'amide B Enabled by Traceless Staudinger Ligation

scientific article published on 03 February 2020

Structural permutation of potent cytotoxin, polytheonamide B: discovery of cytotoxic Peptide with altered activity.

scientific article

Target Identification of Yaku'amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase

scientific article published on 12 September 2018

The total synthesis and functional evaluation of fourteen stereoisomers of yaku'amide B. The importance of stereochemistry for hydrophobicity and cytotoxicity.

scientific article

Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.

scientific article

Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity.

scientific article published on 14 October 2016

Total synthesis and biological evaluation of 19-hydroxysarmentogenin-3-O-a-L-rhamnoside, trewianin, and their aglycons

scientific article published on 25 October 2018

Total synthesis of the large non-ribosomal peptide polytheonamide B.

scientific article published on 21 February 2010

Unified Total Synthesis of Five Bufadienolides

scientific article published on 26 October 2020

List of works by Hiroaki Itoh

Antibody-mediated functional control of a dansylated polytheonamide mimic.

Biological Effects of a Simplified Synthetic Analogue of Ion-Channel-Forming Polytheonamide B on Plasma Membrane and Lysosomes

Chemical construction and structural permutation of potent cytotoxin polytheonamide B: discovery of artificial peptides with distinct functions.

Comprehensive Structure-Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses

Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR

Design, synthesis and functional analysis of dansylated polytheonamide mimic: an artificial peptide ion channel.

Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system.

Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

Dual Chemical Modification of a Polytheonamide Mimic: Rational Design and Synthesis of Ion-Channel-Forming 48-mer Peptides with Potent Cytotoxicity

Full solid-phase total synthesis of macrocyclic natural peptides using four-dimensionally orthogonal protective groups

Phospholipid-Dependent Functions of a Macrocyclic Analogue of the Ion-Channel-Forming Antibiotic Gramicidin A

Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B

Solid-Phase Total Synthesis of Yaku'amide B Enabled by Traceless Staudinger Ligation

Structural permutation of potent cytotoxin, polytheonamide B: discovery of cytotoxic Peptide with altered activity.

Target Identification of Yaku'amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase

The total synthesis and functional evaluation of fourteen stereoisomers of yaku'amide B. The importance of stereochemistry for hydrophobicity and cytotoxicity.

Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.

Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity.

Total synthesis and biological evaluation of 19-hydroxysarmentogenin-3-O-a-L-rhamnoside, trewianin, and their aglycons

Total synthesis of the large non-ribosomal peptide polytheonamide B.

Unified Total Synthesis of Five Bufadienolides