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List of works by Philippe Clézardin

A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden.

scientific article

A convenient clinically relevant model of human breast cancer bone metastasis.

scientific article

A new murine model of osteoblastic/osteolytic lesions from human androgen-resistant prostate cancer

scientific article

A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, beta-thromboglobulin and platelet factor 4 in healthy volunteers.

scientific article published in March 1983

A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis

scientific article

Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone

scientific article published on 01 October 1999

Adjuvant bisphosphonates in early breast cancer: consensus guidance for clinical practice from a European Panel

scientific article published on 17 December 2015

Adjuvant bisphosphonates in patients with breast cancer: does the potency matter?

scientific article

Advances in optical imaging and novel model systems for cancer metastasis research.

scientific article published on 31 October 2007

Anti-tumour activity of zoledronic acid.

scientific article

Bioluminescence imaging of prenylation inhibition--letter

scientific article published on 08 October 2012

Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity

scientific article

Bisphosphonates in cancer therapy

scientific article published on 13 August 2007

Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class.

scientific article published on 22 July 2010

Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma

scientific article

Bone, muscle, and metabolic parameters predict survival in patients with synchronous bone metastases from lung cancers

scientific article

Bone-Targeted Therapies in Cancer-Induced Bone Disease

scientific article

CD36 mediates binding of soluble thrombospondin-1 but not cell adhesion and haptotaxis on immobilized thrombospondin-1 ⬇️

scientific article published on September 1, 1998

Cancer Cell Colonisation in the Bone Microenvironment

scientific article

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

scientific article

Cathepsin K inhibitors as treatment of bone metastasis.

scientific article

Cell attachment and fibrinogen binding properties of platelet and endothelial cell thrombospondin are not affected by structural differences in the 70 and 18 kDa protease-resistant domains

scientific article published on 01 February 1988

Characterization of two murine monoclonal antibodies (P10, P12) directed against different determinants on human blood platelet thrombospondin

scientific article published on 01 January 1986

Combination of anti-angiogenic therapies reduces osteolysis and tumor burden in experimental breast cancer bone metastasis

scientific article published on 03 March 2014

Complex formation of human thrombospondin with osteonectin ⬇️

scientific article published on August 1, 1988

Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.

scientific article

Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo.

scientific article published in July 2008

Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis.

scientific article

Direct and indirect anticancer activity of bisphosphonates: a brief review of published literature

scientific article published on 07 October 2011

Dual Function of ERRα in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin ⬇️

scientific article published on July 6, 2011

ERRα expression in bone metastases leads to an exacerbated anti-tumor immune response

scientific article published on 04 May 2020

Early Detection of Bone Metastases in a Murine Model Using Fluorescent Human Breast Cancer Cells: Application to the Use of the Bisphosphonate Zoledronic Acid in the Treatment of Osteolytic Lesions ⬇️

scientific article published on November 1, 2001

Effect of intra-tibial injection on mechanical properties of mouse bone

scientific article published on 01 October 2017

Effects of bone-targeted agents on cancer progression and mortality.

scientific article published on 02 July 2012

Emerging therapies in bone metastasis

scientific article published on 30 April 2015

Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone

scientific article published on 20 October 2016

Expression and localisation of alphav integrins in human odontoblasts.

scientific article

Frequent low-dose bisphosphonate therapy

scientific article published on 15 August 2007

High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo.

scientific article published on 6 June 2011

How do bisphosphonates inhibit bone metastasis in vivo?

scientific article

Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo

scientific article published on 01 September 2005

Identification and characterization of fragments of major glycoproteins from platelet membrane after chymotrypsin treatment

scientific article published on 01 April 1985

Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers

scientific article

In vivo phosphoantigen levels in bisphosphonate-treated human breast tumors trigger Vγ9Vδ2 T-cell antitumor cytotoxicity through ICAM-1 engagement.

scientific article

Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.

scientific article

Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression

scientific article published on 21 September 2013

Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone

scientific article published on 21 June 2002

Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone

scientific article

International Society of Geriatric Oncology (SIOG) clinical practice recommendations for the use of bisphosphonates in elderly patients.

scientific article published on 26 January 2007

Isolation of thrombospondin released from thrombin-stimulated human platelets by fast protein liquid chromatography on an anion-exchange Mono-Q column

scientific article published on 01 July 1984

Localization of thrombospondin, CD36 and CD51 during prenatal development of the human mammary gland

scientific article published on 01 August 1994

Low-Intensity Ultrasound Promotes Clathrin-Dependent Endocytosis for Drug Penetration into Tumor Cells

scientific article published on 26 July 2015

Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer

scientific article

Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

scientific article

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.

scientific article

Lysophosphatidic acid: a new link between blood platelets and bone metastasis

scientific article published in April 2005

Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone

scientific article published on 14 October 2016

Mechanisms of action of bisphosphonates in oncology: a scientific concept evolving from antiresorptive to anticancer activities

scientific article published on 06 February 2013

Metastasis and bone loss: advancing treatment and prevention.

scientific article

MiRNAs and snoRNAs in Bone Metastasis: Functional Roles and Clinical Potential

scientific article published in 2022

Molecularly targeted therapies in breast cancer bone metastases

scientific article published on 01 January 2010

Mutational profiling of bone metastases from lung adenocarcinoma: results of a prospective study (POUMOS-TEC)

scientific article

Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention.

scientific article published on 18 August 2009

Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase

scientific article published on 20 October 2010

Non-coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance

scientific article published on 18 August 2019

Oligometastatic bone disease. Can limited metastatic bone disease be cured? Is there room for local ablative treatments?

scientific article

One-step procedure for the rapid isolation of mouse monoclonal antibodies and their antigen binding fragments by fast protein liquid chromatography on a mono Q anion-exchange column

scientific article published on 01 January 1985

Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation

scientific article published on 10 April 2017

Pathophysiology of bone metastases from solid malignancies

scientific article published on 09 May 2017

Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs

scientific article

Platelet membrane glycoprotein abnormalities in patients with myeloproliferative disorders and secondary thrombocytosis

Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.

scientific article published on December 2004

Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1

scientific article published on 01 February 2000

Production, characterization, and use of monoclonal antibodies directed against human blood platelet thrombospondin: immunologic comparison with human endothelial and fibroblast thrombospondins

scientific article published on 01 July 1987

RANK/RANKL pathway in cancer: Biological activity beyond bone?

scientific article

Recent insights into the role of integrins in cancer metastasis.

scientific article

Structural and immunological comparison of human thrombospondins isolated from platelets and from culture supernatants of endothelial cells and fibroblasts. Evidence for a thrombospondin polymorphism

scientific article published on 01 September 1986

Structural and immunological differences between human platelet and endothelial thrombospondins

scientific article published on 01 February 1986

TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival

scientific article

TWIST1 expression in breast cancer cells facilitates bone metastasis formation.

scientific article published on August 2014

Tandem purification of IgM monoclonal antibodies from mouse ascites fluids by anion-exchange and gel fast protein liquid chromatography

scientific article published on 01 February 1986

Tandem purification of mouse IgM monoclonal antibodies produced in vitro using anion-exchange and gel fast protein liquid chromatography

scientific article published on 01 May 1986

Tandem separation of labelled human blood platelet membrane glycoproteins by anion-exchange and gel fast protein liquid chromatography

scientific article published on 01 June 1985

Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo ⬇️

scientific article published on May 24, 2012

Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

scientific article published on 20 December 2011

The C-Terminal Intact Forms of Periostin (iPTN) Are Surrogate Markers for Osteolytic Lesions in Experimental Breast Cancer Bone Metastasis

scientific article published on 18 June 2018

The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth

scientific article published on 14 January 2011

The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer ⬇️

scientific article

The Molecular Basis of Bisphosphonate Activity: A Preclinical Perspective ⬇️

scientific article published on June 1, 2010

The role of osteoclasts in breast cancer bone metastasis.

scientific article

Therapeutic targets for bone metastases in breast cancer ⬇️

scientific article published on April 6, 2011

Thrombospondin (TSP1) mediates in vitro proliferation of human MG-63 osteoblastic cells induced by alpha-thrombin

scientific article published on 01 August 1993

Thrombospondin in milk, other breast secretions, and breast tissue.

scientific article published in July 1987

Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells. A model to study the different effects of thrombospondin in cell adhesion

scientific article published on 01 May 1989

Tryptic peptide map analysis of the major human blood platelet membrane glycoproteins separated by two-dimensional polyacrylamide gel electrophoresis

scientific article published on 01 August 1982

Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases.

scientific article

Tumour-derived miRNAs and bone metastasis

scientific article

Unseeded Inertial Cavitation for Enhancing the Delivery of Chemotherapies: A Safety Study

scientific article published on 23 October 2015

Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells

scientific article

[Pathophysiology of bone metastases and new molecular targets involved in bone remodelling].

scientific article

[The role of RANK/RANKL/osteoprotegerin (OPG) triad in cancer-induced bone diseases: physiopathology and clinical implications]

scientific article published on 01 July 2011

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