Search filters

List of works by Chihiro Hasegawa

A Framework for Simplification of Quantitative Systems Pharmacology Models in Clinical Pharmacology

scientific article published on 04 July 2020

An oral cathepsin K inhibitor ONO-5334 inhibits N-terminal and C-terminal collagen crosslinks in serum and urine at similar plasma concentrations in postmenopausal women.

scientific article published on 15 July 2015

Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

scientific article

Automated Scale Reduction of Nonlinear QSP Models With an Illustrative Application to a Bone Biology System

scientific article published on 13 August 2018

Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations.

scientific article published on 26 May 2017

Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

scientific article published on 28 February 2014

Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females

scientific article published on 10 October 2013

Population pharmacokinetics and exposure-response relationship of a muscarinic receptor antagonist, imidafenacin

scientific article published on 23 October 2012

Population pharmacokinetics of landiolol hydrochloride in healthy subjects.

scientific article published in January 2008

Reusing Smaller Versions of Large Models: A Case Example of Reuse of a Simplified Bone Model

scientific article published on 27 August 2019

Selection and Qualification of Simplified QSP Models When Using Model Order Reduction Techniques.

scientific article published on 27 November 2017

The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling.

scientific article

Paulina is supported by:

About Paulina

Help