List of works - Scott Ayton

A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe(2+) under physiologically relevant conditions.

scientific article published on 23 August 2014

A delicate balance: Iron metabolism and diseases of the brain.

scientific article published on 18 July 2013

Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.

scientific article

Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers.

scientific article published on 28 November 2016

Association of metals with the risk and clinical characteristics of Parkinson's disease

scientific article published on 28 May 2018

Axonal dispatch of iron in neuronal signaling

scientific article published on 01 December 2019

Biometals and their therapeutic implications in Alzheimer's disease.

scientific article

Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Disease

scientific article published on 01 January 2020

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

scientific article published on 18 February 2019

Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease

scientific article published on 19 June 2019

Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline

Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology

scientific article published on 14 December 2018

Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron.

scientific article published on 7 February 2014

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

scientific article published on 18 March 2015

CuII (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

scientific article published on 14 January 2020

Decreasing iron neurotoxicity in pantothenate kinase-associated neurodegeneration

scientific article published on 01 July 2019

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load.

scientific article published on 11 July 2017

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

scientific article

Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau.

scientific article published in January 2017

Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study.

scientific article

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

scientific article published on 19 May 2015

Ferroptosis and cell death mechanisms in Parkinson's disease.

scientific article published on 9 January 2017

GSK-3 in Neurodegenerative Diseases.

scientific article

Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels

scientific article published on 24 January 2014

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease

scientific article

Iron and Alzheimer's Disease: An Update on Emerging Mechanisms

scientific article published on 01 January 2018

Lithium suppression of tau induces brain iron accumulation and neurodegeneration. ⬇️

scientific article published on 12 July 2016

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

scientific article published on 01 October 2018

Metallostasis in Alzheimer's disease.

scientific article

Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis

scientific article published on 01 May 2019

More evidence is needed. Iron, incident cognitive decline and dementia: a systematic review

article

Motor and cognitive deficits in aged tau knockout mice in two background strains.

scientific article

Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease

scientific article published in October 2017

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis

scientific article published on 13 August 2019

Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration

scientific article published on 16 January 2014

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

scientific article published on 31 July 2018

PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease

scientific article published in January 2012

Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.

scientific article

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.

scientific article

Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations

Serotonergic lesions of the dorsal hippocampus differentially modulate locomotor hyperactivity induced by drugs of abuse in rats: implications for schizophrenia.

scientific article published on 23 July 2009

Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias

scientific article published on 4 February 2015

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

scientific article published on 29 January 2012

Tau protein: relevance to Parkinson's disease

scientific article

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

scientific article

The Aβ-induced NFAT apoptotic pathway is also activated by GSK-3 inhibition: implications for Alzheimer therapeutics.

scientific article published in July 2012

The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update

scientific article published on 19 September 2016

The Essential Elements of Alzheimer's Disease

scientific article published on 20 November 2020

The effect of dopamine on MPTP-induced rotarod disability.

scientific article published on 2 April 2013

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

scientific article published on 2 April 2012

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

scientific article

Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson's substantia nigra

scientific article published on 02 September 2016

Treating Alzheimer's disease by targeting iron

scientific article published on 11 February 2019

Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease.

scientific article published on 12 July 2016

Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?

scientific article published on 21 January 2019

α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.

scientific article published on 13 May 2010

List of works by Scott Ayton

A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe(2+) under physiologically relevant conditions.

A delicate balance: Iron metabolism and diseases of the brain.

Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.

Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers.

Association of metals with the risk and clinical characteristics of Parkinson's disease

Axonal dispatch of iron in neuronal signaling

Biometals and their therapeutic implications in Alzheimer's disease.

Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Disease

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease

Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline

Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology

Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron.

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

CuII (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Decreasing iron neurotoxicity in pantothenate kinase-associated neurodegeneration

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load.

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau.

Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study.

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Ferroptosis and cell death mechanisms in Parkinson's disease.

GSK-3 in Neurodegenerative Diseases.

Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease

Iron and Alzheimer's Disease: An Update on Emerging Mechanisms

Lithium suppression of tau induces brain iron accumulation and neurodegeneration. ⬇️

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Metallostasis in Alzheimer's disease.

Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis

More evidence is needed. Iron, incident cognitive decline and dementia: a systematic review

Motor and cognitive deficits in aged tau knockout mice in two background strains.

Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis

Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease

Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.

Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations

Serotonergic lesions of the dorsal hippocampus differentially modulate locomotor hyperactivity induced by drugs of abuse in rats: implications for schizophrenia.

Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

Tau protein: relevance to Parkinson's disease

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

The Aβ-induced NFAT apoptotic pathway is also activated by GSK-3 inhibition: implications for Alzheimer therapeutics.

The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update

The Essential Elements of Alzheimer's Disease

The effect of dopamine on MPTP-induced rotarod disability.

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson's substantia nigra

Treating Alzheimer's disease by targeting iron

Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease.

Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?

α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.