List of works - Xavier Pannecoucke

1,4 Addition of unprotected pyrrole onto chiral acrylamides: toward synthesis of new polypeptidic architectures

scientific article published on 21 November 2014

1,4-Addition of the CF3 group, perfluoroalkyl groups and functionalized difluoromethylated moieties: An overview

article

18F-Fluoroform: a 18F-trifluoromethylating agent for the synthesis of SCF218F-aromatic derivatives.

scientific article

2-Nitroglycals: Versatile Building Blocks for the Synthesis of 2-Aminoglycosides

article published in 2014

A facile and mild method for the synthesis of terminal bromofluoroolefins via diethylzinc-promoted Wittig reaction

scientific article published on 01 June 2004

A novel diastereoselective synthesis of (Z)-fluoroalkenes via a Nozaki-Hiyama-Kishi-type reaction

scientific article published on 01 March 2005

A practical and straightforward access to fluorinated homoallylic alcohols in aqueous media

A straightforward and highly diastereoselective access to functionalized monofluorinated cyclopropanes via a Michael initiated ring closure reaction

scientific article published on 18 October 2013

Access to Difluoromethylated Alkynes through the Castro-Stephens Reaction

Addition of Electrophilic Radicals to 2-Benzyloxyglycals: Synthesis and Functionalization of Fluorinated α-C-Glycosides and Derivatives

article

An Electrophilic Reagent for the Direct Introduction of the SCF2 PO(OEt)2 Group to Molecules

scientific article published on 26 September 2016

Asymmetric synthesis of cyclopropanes with a monofluorinated quaternary stereocenter

scientific article published on 27 September 2012

Catalytic Enantioselective Synthesis of Halocyclopropanes

scientific article published on 4 March 2016

Chiral dipeptide mimics possessing a fluoroolefin moiety: a relevant tool for conformational and medicinal studies.

scientific article published on 19 March 2007

Copper Catalyzed β-Difluoroacetylation of Dihydropyrans and Glycals by Means of Direct C–H Functionalization

scientific article published on 21 June 2013

Copper-Catalyzed Direct Arylation of Cyclic Enamides Using Diaryliodonium Salts

scientific article published on 28 December 2012

Copper-Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C-2 CF2H Derivatives

scientific article published on 09 July 2014

Copper-Catalyzed Innate Ethoxycarbonyldifluoromethylation of Electron-Rich Arenes

article published in 2015

Copper-Mediated Direct Functionalization of Unsaturated C–C Bonds with Ethyl Bromo(difluoro)acetate: A Straightforward Access to Highly Valuable Difluoromethylated Alkenes

scholarly article by Tatiana Besset et al published 28 May 2014 in Synthesis

Copper-Mediated Formation of Aryl, Heteroaryl, Vinyl and Alkynyl Difluoromethylphosphonates: A General Approach to Fluorinated Phosphate Mimics

scientific article published on 11 September 2015

Copper-Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach

article

Copper-catalyzed direct C-H fluoroalkenylation of heteroarenes

scientific article published on 25 November 2015

Copper-catalyzed olefinic C-H difluoroacetylation of enamides

scientific article published in June 2014

Copper‐Photocatalyzed Borylation of Organic Halides under Batch and Continuous‐Flow Conditions

scientific article published on 06 February 2019

Diastereomeric fluoroolefins as peptide bond mimics prepared by asymmetric reductive amination of alpha-fluoroenones

scientific article published on 01 January 2007

Diastereoselective alkylation of 2,3,4,6-Di-O-isopropylidene-2-keto-L-gulonic amides. Application to the asymmetric synthesis of 1-substituted-1,2,3,4-tetrahydroisoquinolines and 1-substituted-1,2,3,4,-tetrahydro-beta-carbolines.

scientific article published in December 2001

Diethylzinc-Mediated Addition of 2,2-Dibromo-2-fluoroacetamides to Carbonyl Compounds: Synthesis of α-Bromo-α-fluoro-β-hydroxy Amides and/or (Z)-Fluorovinyl Amides

article

Direct Vicinal Difunctionalization of Alkynes: An Efficient Approach Towards the Synthesis of Highly Functionalized Fluorinated Alkenes

Efficient access to fluorinated homoallylic alcohols through an indium promoted fluoroallylation reaction

scholarly article by Gérald Lemonnier et al published May 2014 in Tetrahedron

First stereospecific synthesis of (E)- or (Z)-alpha-fluoroenones via a kinetically controlled Negishi coupling reaction.

scientific article published in May 2006

First synthesis of diethyl N-acetyl-glycosamine-1-difluoromethylphosphonate from 2-nitroglycals as phosphate analog

Fluorinated pseudopeptide analogues of the neuropeptide 26RFa: synthesis, biological, and structural studies.

scientific article published on 12 August 2013

Fluorine & chirality: how to create a nonracemic stereogenic carbon-fluorine centre?

scientific article published on 16 October 2009

Fluoro-C-glycosides and fluoro-carbasugars, hydrolytically stable and synthetically challenging glycomimetics.

scientific article published on 04 December 2012

General Catalytic Enantioselective Access to Monohalomethyl and Trifluoromethyl Cyclopropanes

scientific article published on 25 June 2018

Indium-Promoted Diastereoselective Addition of Fluorinated Haloallylic Derivatives to Imines

article

Indium-Promoted Reformatsky Reaction: A Straightforward Access to β-Amino and β-Hydroxy α,α-Difluoro Carbonyl Compounds

scientific article published on 08 October 2012

Intramolecular hydrogen bonding in depsipeptides containing endo-3,6-tricyclo[6.2.1.0(2,7)]undeca-4,9-diene-3,6-endo-diol.

scientific article published in June 2004

New phenylselanyl group activation: synthesis of aziridines and oxazolidin-2-ones.

scientific article

New synthesis of cis 5-tert-butyl-L-proline via cuprate. Evaluation as a cis proline mimetic in a biological active octapeptide.

scientific article published in February 2006

One-step synthesis of highly functionalized monofluorinated cyclopropanes from electron-deficient alkenes

scientific article published on 23 April 2012

Palladium(II)-catalyzed directed trifluoromethylthiolation of unactivated C(sp³)-H bonds

scientific article published on 30 March 2015

Palladium-Catalysed Synthesis of α-(Trifluoromethyl)styrenes by Means of Directed C-H Bond Functionalization

Palladium‐ and Copper‐Catalyzed Stereocontrolled Direct CH Fluoroalkenylation of Heteroarenes using gem‐Bromofluoroalkenes ⬇️

scientific article published on January 30, 2013

Pd- and Cu-catalyzed stereo- and regiocontrolled decarboxylative/C-H fluoroalkenylation of heteroarenes.

scientific article

Recent Advances in the Synthesis of SCF2 H- and SCF2 FG-Containing Molecules

scientific article published on 13 September 2016

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp(2) ) and C(sp) Centers.

scientific article

Recent progress in direct introduction of fluorinated groups on alkenes and alkynes by means of C-H bond functionalization.

scientific article

Regio- and diastereoselective Cu-mediated trifluoromethylation of functionalized alkenes.

scientific article published on 10 December 2013

Rhodium-catalyzed cyclopropanation of fluorinated olefins: a straightforward route to highly functionalized fluorocyclopropanes

scientific article published on 13 March 2015

Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: mechanistic evidence for an enantiospecific pathway

scientific article published on 15 May 2012

Stereoselective Access to β-C-Glycosamines by Nitro-Michael Addition of Organolithium Reagents

article

Stereoselectivity of the Honda–Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with α-Oxygenated Sulfinylimines

scientific article published on 18 April 2014

Stereospecific Synthesis of Tri- and Tetrasubstituted α-Fluoroacrylates by Mizoroki-Heck Reaction.

scientific article published on 26 January 2016

Straightforward preparation of functionalized α-CF2-galactosides through an oxygen to carbon acyl migration

scientific article published on 11 April 2011

Syntheses and applications of monofluorinated cyclopropanes.

scientific article published on 29 October 2012

Synthesis and Reactivity ofN-tert-Butanesulfinyl Glycosylamines

Synthesis and immunological evaluation of fluorinated α-C-galactosylceramide analogs

Synthesis and oxidative rearrangement of selenenylated dihydropyrans

scientific article published on 27 February 2008

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.

scientific article published on 22 April 2015

Synthesis of alpha-substituted beta-amidophosphines by diastereoselective alkylation. A new access to chiral ligands for asymmetric catalysis

scientific article published on 01 August 2001

Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.

scientific article

Synthesis of fluorinated pseudopeptides: metal mediated reversal of stereochemistry in diastereoselective addition of organometallic reagents to N-(tert-butanesulfinyl)-α-fluoroenimines

scientific article published on 15 February 2011

Toward the Synthesis of Fluorinated Analogues of HCV NS3/4A Serine Protease Inhibitors Using Methyl α-Amino-β-fluoro-β-vinylcyclopropanecarboxylate as Key Intermediate.

scientific article published on 8 June 2015

[(18) F]CuCF3 : a [(18) F]trifluoromethylating agent for arylboronic acids and aryl iodides.

scientific article published on 24 June 2014

List of works by Xavier Pannecoucke

1,4 Addition of unprotected pyrrole onto chiral acrylamides: toward synthesis of new polypeptidic architectures

1,4-Addition of the CF3 group, perfluoroalkyl groups and functionalized difluoromethylated moieties: An overview

18F-Fluoroform: a 18F-trifluoromethylating agent for the synthesis of SCF218F-aromatic derivatives.

2-Nitroglycals: Versatile Building Blocks for the Synthesis of 2-Aminoglycosides

A facile and mild method for the synthesis of terminal bromofluoroolefins via diethylzinc-promoted Wittig reaction

A novel diastereoselective synthesis of (Z)-fluoroalkenes via a Nozaki-Hiyama-Kishi-type reaction

A practical and straightforward access to fluorinated homoallylic alcohols in aqueous media

A straightforward and highly diastereoselective access to functionalized monofluorinated cyclopropanes via a Michael initiated ring closure reaction

Access to Difluoromethylated Alkynes through the Castro-Stephens Reaction

Addition of Electrophilic Radicals to 2-Benzyloxyglycals: Synthesis and Functionalization of Fluorinated α-C-Glycosides and Derivatives

An Electrophilic Reagent for the Direct Introduction of the SCF2 PO(OEt)2 Group to Molecules

Asymmetric synthesis of cyclopropanes with a monofluorinated quaternary stereocenter

Catalytic Enantioselective Synthesis of Halocyclopropanes

Chiral dipeptide mimics possessing a fluoroolefin moiety: a relevant tool for conformational and medicinal studies.

Copper Catalyzed β-Difluoroacetylation of Dihydropyrans and Glycals by Means of Direct C–H Functionalization

Copper-Catalyzed Direct Arylation of Cyclic Enamides Using Diaryliodonium Salts

Copper-Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C-2 CF2H Derivatives

Copper-Catalyzed Innate Ethoxycarbonyldifluoromethylation of Electron-Rich Arenes

Copper-Mediated Direct Functionalization of Unsaturated C–C Bonds with Ethyl Bromo(difluoro)acetate: A Straightforward Access to Highly Valuable Difluoromethylated Alkenes

Copper-Mediated Formation of Aryl, Heteroaryl, Vinyl and Alkynyl Difluoromethylphosphonates: A General Approach to Fluorinated Phosphate Mimics

Copper-Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach

Copper-catalyzed direct C-H fluoroalkenylation of heteroarenes

Copper-catalyzed olefinic C-H difluoroacetylation of enamides

Copper‐Photocatalyzed Borylation of Organic Halides under Batch and Continuous‐Flow Conditions

Diastereomeric fluoroolefins as peptide bond mimics prepared by asymmetric reductive amination of alpha-fluoroenones

Diastereoselective alkylation of 2,3,4,6-Di-O-isopropylidene-2-keto-L-gulonic amides. Application to the asymmetric synthesis of 1-substituted-1,2,3,4-tetrahydroisoquinolines and 1-substituted-1,2,3,4,-tetrahydro-beta-carbolines.

Diethylzinc-Mediated Addition of 2,2-Dibromo-2-fluoroacetamides to Carbonyl Compounds: Synthesis of α-Bromo-α-fluoro-β-hydroxy Amides and/or (Z)-Fluorovinyl Amides

Direct Vicinal Difunctionalization of Alkynes: An Efficient Approach Towards the Synthesis of Highly Functionalized Fluorinated Alkenes

Efficient access to fluorinated homoallylic alcohols through an indium promoted fluoroallylation reaction

First stereospecific synthesis of (E)- or (Z)-alpha-fluoroenones via a kinetically controlled Negishi coupling reaction.

First synthesis of diethyl N-acetyl-glycosamine-1-difluoromethylphosphonate from 2-nitroglycals as phosphate analog

Fluorinated pseudopeptide analogues of the neuropeptide 26RFa: synthesis, biological, and structural studies.

Fluorine & chirality: how to create a nonracemic stereogenic carbon-fluorine centre?

Fluoro-C-glycosides and fluoro-carbasugars, hydrolytically stable and synthetically challenging glycomimetics.

General Catalytic Enantioselective Access to Monohalomethyl and Trifluoromethyl Cyclopropanes

Indium-Promoted Diastereoselective Addition of Fluorinated Haloallylic Derivatives to Imines

Indium-Promoted Reformatsky Reaction: A Straightforward Access to β-Amino and β-Hydroxy α,α-Difluoro Carbonyl Compounds

Intramolecular hydrogen bonding in depsipeptides containing endo-3,6-tricyclo[6.2.1.0(2,7)]undeca-4,9-diene-3,6-endo-diol.

New phenylselanyl group activation: synthesis of aziridines and oxazolidin-2-ones.

New synthesis of cis 5-tert-butyl-L-proline via cuprate. Evaluation as a cis proline mimetic in a biological active octapeptide.

One-step synthesis of highly functionalized monofluorinated cyclopropanes from electron-deficient alkenes

Palladium(II)-catalyzed directed trifluoromethylthiolation of unactivated C(sp³)-H bonds

Palladium-Catalysed Synthesis of α-(Trifluoromethyl)styrenes by Means of Directed C-H Bond Functionalization

Palladium‐ and Copper‐Catalyzed Stereocontrolled Direct CH Fluoroalkenylation of Heteroarenes using gem‐Bromofluoroalkenes ⬇️

Pd- and Cu-catalyzed stereo- and regiocontrolled decarboxylative/C-H fluoroalkenylation of heteroarenes.

Recent Advances in the Synthesis of SCF2 H- and SCF2 FG-Containing Molecules

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp(2) ) and C(sp) Centers.

Recent progress in direct introduction of fluorinated groups on alkenes and alkynes by means of C-H bond functionalization.

Regio- and diastereoselective Cu-mediated trifluoromethylation of functionalized alkenes.

Rhodium-catalyzed cyclopropanation of fluorinated olefins: a straightforward route to highly functionalized fluorocyclopropanes

Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: mechanistic evidence for an enantiospecific pathway

Stereoselective Access to β-C-Glycosamines by Nitro-Michael Addition of Organolithium Reagents

Stereoselectivity of the Honda–Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with α-Oxygenated Sulfinylimines

Stereospecific Synthesis of Tri- and Tetrasubstituted α-Fluoroacrylates by Mizoroki-Heck Reaction.

Straightforward preparation of functionalized α-CF2-galactosides through an oxygen to carbon acyl migration

Syntheses and applications of monofluorinated cyclopropanes.

Synthesis and Reactivity ofN-tert-Butanesulfinyl Glycosylamines

Synthesis and immunological evaluation of fluorinated α-C-galactosylceramide analogs

Synthesis and oxidative rearrangement of selenenylated dihydropyrans

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.

Synthesis of alpha-substituted beta-amidophosphines by diastereoselective alkylation. A new access to chiral ligands for asymmetric catalysis

Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.

Synthesis of fluorinated pseudopeptides: metal mediated reversal of stereochemistry in diastereoselective addition of organometallic reagents to N-(tert-butanesulfinyl)-α-fluoroenimines

Toward the Synthesis of Fluorinated Analogues of HCV NS3/4A Serine Protease Inhibitors Using Methyl α-Amino-β-fluoro-β-vinylcyclopropanecarboxylate as Key Intermediate.

[(18) F]CuCF3 : a [(18) F]trifluoromethylating agent for arylboronic acids and aryl iodides.