List of works by Massimo Federici

A genetic marker of hyperuricemia predicts cardiovascular events in a meta-analysis of three cohort studies in high risk patients

scientific article

A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse

scientific article published on April 2014

A1c value for diabetes diagnosis in subjects with established cardiovascular disease

scientific article published on 27 March 2015

Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms.

scientific article published on 9 April 2009

Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-ce

scientific article published on 4 March 2004

Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD.

scientific article published on 9 May 2008

Adiponectin isoforms in elderly patients with or without coronary artery disease.

scientific article

Age-related different relationships between ectopic adipose tissues and measures of central obesity in sedentary subjects.

scientific article

Atherosclerosis severity but not undiagnosed diabetes predicts new cardiovascular events of subjects in secondary cardiovascular prevention.

scientific article published on 24 May 2012

Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling

scientific article published on 01 August 2006

Can renin inhibition by Aliskiren prove itself in atherosclerosis prevention?

scientific article published on 28 October 2014

Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients.

scientific article published on 12 September 2006

Cytokines and metabolic syndrome: the perfect storm for arterial aging

scientific article published on 26 January 2011

Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness

scientific article published on 7 October 2011

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

scientific article (publication date: October 2001)

Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues

scientific article published on 01 May 1997

Do stem cells cause aging-related intimal medial thickening?

scientific article published on 24 July 2012

Do we need research on reporting on diabetes research?

scientific article published on 9 January 2016

Dysfunctional dopaminergic neurotransmission in asocial BTBR mice

scientific article

Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice

scientific article

Effect of ezetimibe on cholesterol absorption and lipoprotein composition in diabetes and metabolic syndrome.

scientific article published on February 2015

Effects of Dipeptidyl Peptidase 4 Inhibitors and Sodium-Glucose Linked coTransporter-2 Inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis

scientific article published on 27 June 2016

Effects of whole body vibration plus diet on insulin-resistance in middle-aged obese subjects.

scientific article

Elbow deformities in a patient with mandibuloacral dysplasia type A

scientific article published on 01 November 2010

Endothelial function and arterial stiffness in normotensive normoglycemic first-degree relatives of diabetic patients are independent of the metabolic syndrome.

scientific article published in November 2007

Expression of tissue inhibitor of metalloprotease 3 is reduced in ischemic but not neuropathic ulcers from patients with type 2 diabetes mellitus.

scientific article

FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis.

scientific article published on 16 July 2015

Functionalized gold nanoparticles for topical delivery of methotrexate for the possible treatment of psoriasis.

scientific article published on 16 January 2016

GLUT2 and glucokinase expression is coordinately regulated by sulfonylurea

scientific article published on 01 July 1999

Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver.

scientific article published on 29 October 2010

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

article

Gut microbiome and cardiometabolic risk

scientific article published on 01 December 2019

High mobility group box 1 is a novel substrate of dipeptidyl peptidase-IV.

scientific article

IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity.

scientific article published on 15 January 2014

ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids

ITCH deficiency protects from diet-induced obesity.

scientific article

ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.

scientific article

Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma

scientific article published in 2013

Impact of light therapy on rotating night shift workers: the EuRhythDia study

scientific article published in 2022

Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.

scientific article published in July 2004

Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients

scientific article published on 01 November 1997

Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity

scientific article published on 01 August 1998

Increased expression of low-affinity insulin receptor isoform and insulin/insulin-like growth factor-I hybrid receptors in term placenta from insulin-resistant women with gestational hypertension

scientific article published on 01 August 1996

Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice.

scientific article published in January 2010

Insulin resistance affects gene expression in endothelium

scientific article published on 01 February 2008

Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes.

scientific article published on August 2013

Insulin resistance and increased intimal medial thickness in glucose tolerant offspring of type 2 diabetic subjects carrying the D298D genotype of endothelial nitric oxide synthase.

scientific article published in February 2006

Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.

scientific article

Iron status in obesity: An independent association with metabolic parameters and effect of weight loss.

scientific article published on 4 March 2015

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

scientific article published on 7 May 2021

Joint effect of insulin signaling genes on all-cause mortality

scientific article

Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance

scientific article

Lipidomics and metabolomics signatures of SARS-CoV-2 mediators/receptors in peripheral leukocytes, jejunum and colon

scientific article published on 08 November 2021

Liver protein profiles in insulin receptor-knockout mice reveal novel molecules involved in the diabetes pathophysiology.

scientific article

Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice

scientific article published on 04 June 2014

Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C

scientific article

Metabolomics signature improves the prediction of cardiovascular events in elderly subjects.

scientific article published on 18 November 2013

MiR-216a: a link between endothelial dysfunction and autophagy

scientific article published on 30 January 2014

Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes.

scientific article published on 23 July 2007

MicroPPARticle in atherosclerosis: guilty or innocent by-standers?

scientific article published on 14 April 2011

MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1.

scientific article published on 28 September 2009

MicroRNA Manipulation to Boost Endothelial Regeneration: Are We Ready for the Next Steps?

scientific article published on 01 February 2019

MicroRNAs in vascular aging and atherosclerosis.

scientific article published on 27 March 2014

Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin-1 in type 2 diabetes patients.

scientific article published on 13 April 2016

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

scientific article published on 25 June 2018

Nonalcoholic fatty liver disease and age are strong indicators for atherosclerosis in morbid obesity

scientific article published on 30 January 2015

Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation.

scientific article published on 19 May 2010

Omental adipose tissue fibrosis and insulin resistance in severe obesity.

scientific article published on 10 August 2015

Oral hypoglycemic agents and the heart failure conundrum: Lessons from and for outcome trials.

scientific article published on 18 June 2015

Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice

scientific article published on 20 October 2011

Parathyroid hormone and insulin resistance in distinct phenotypes of severe obesity: a cross-sectional analysis in middle-aged men and premenopausal women.

scientific article published in October 2012

Peroxiredoxin 6, a novel player in the pathogenesis of diabetes

scientific article published on 19 June 2014

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse

scientific article published in July 2015

Pioglitazone improves endothelial and adipose tissue dysfunction in pre-diabetic CAD subjects

scientific article published on 28 December 2010

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

scientific article

Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.

scientific article

Posttranslational modulation of FoxO1 contributes to cardiac remodeling in post-ischemic heart failure.

scientific article published on 7 April 2016

Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice.

scientific article published on 13 November 2017

Publisher Correction: Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

scientific article published on 01 October 2018

Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs.

scientific article published on December 2013

Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient

scientific article published in September 2002

Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells

scientific article published in July 2010

Serum glucocorticoid inducible kinase (SGK)-1 protects endothelial cells against oxidative stress and apoptosis induced by hyperglycaemia.

scientific article

Serum- and Glucocorticoid-Inducible Kinase 1 Delay the Onset of Endothelial Senescence by Directly Interacting with Human Telomerase Reverse Transcriptase.

scientific article published on 31 July 2015

Sildenafil reduces insulin-resistance in human endothelial cells

scientific article

TAp73 depletion accelerates aging through metabolic dysregulation

scientific article

TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice

scientific article

TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.

scientific article published on 6 January 2012

The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.

scientific article

The Angiogenic Factor PlGF Mediates a Neuroimmune Interaction in the Spleen to Allow the Onset of Hypertension

scientific article published on 07 November 2014

The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

scientific article

The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients

scientific article

The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy

scientific article published in March 2003

The endothelium abridges insulin resistance to premature aging

scientific article

The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus

scientific article published on 27 December 2013

The role of ADAM17 in metabolic inflammation.

scientific article published on 25 January 2013

The strange case of G972R IRS-1 variant and diabetes. Do type 1 and type 2 diabetes share common genes?

scientific article published in April 2004

Tick-tock: is your cardiometabolic risk on the clock?

scientific article published on 06 January 2014

Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha

scientific article

Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine.

scientific article

Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

scientific article

Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.

scientific article published on 19 January 2008

Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus.

scientific article published in March 2007

Venous distal bypass should be considered as the gold standard to finally attempt limb salvage in patients with severe critical limb ischemia and diabetic foot, or under dialysis

scientific article published on 03 April 2020

miR-146a is modulated in human endothelial cell with aging

scientific article

sPLA2: linking atherosclerosis to aneurysm progression

scientific article published on 10 November 2010

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