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List of works by Matthew J Hilton

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

scientific article

An FGF-WNT gene regulatory network controls lung mesenchyme development

scientific journal article

An integrated physical map of 8q22-q24: use in positional cloning and deletion analysis of Langer-Giedion syndrome.

scientific article

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

scientific article

CCN1 Regulates Chondrocyte Maturation and Cartilage Development.

scientific article published on 12 September 2015

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development

scientific article published on March 2012

Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity.

scientific article

Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis.

scientific article

Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus

scientific article

Demineralized murine skeletal histology

scientific article published on 01 January 2014

EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development

scientific article published on 01 March 2005

Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.

scientific article

Engineering superficial zone features in tissue engineered cartilage.

scientific article published on 27 December 2012

Establishment of an index with increased sensitivity for assessing murine arthritis.

scientific article

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development

scientific article published on 09 May 2016

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

scientific article published on 01 September 2005

Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing.

scientific article published on 14 September 2010

Isolation and culture of murine primary chondrocytes

scientific article published in January 2014

Mechanism of shortened bones in mucopolysaccharidosis VII

scientific article published on 25 March 2009

Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research.

scientific article

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.

scientific article

NOTCH signaling in skeletal progenitors is critical for fracture repair

scientific article published on 7 March 2016

NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.

scientific article

NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells

scientific article published on 22 December 2007

Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.

scientific article

Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance

scientific article published on 30 October 2015

Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.

scientific article published on 5 May 2016

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

scientific article published on 24 February 2008

PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate

scientific article published on February 2015

RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.

scientific article

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

scientific article

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

scientific article published on April 2008

Regulation of chondrogenesis and chondrocyte differentiation by stress.

scientific article published on February 2008

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

scientific journal article

Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes

scientific article published on June 2012

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

scientific article published on 13 January 2009

Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus

scientific article published on 29 December 2015

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

scientific article published on 21 October 2013

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.

scientific article

TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease

scientific article

Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.

scientific article published on 18 May 2007

Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

scientific article published on September 2011

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool

scientific article published on 9 March 2017

The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice.

scientific article published on 3 January 2014

Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation

scientific article

Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice

scientific article

Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.

scientific article published on 4 June 2016

Whole-mount in situ hybridization on murine skeletogenic tissues

scientific article published on 01 January 2014

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