Search filters

List of works by Maria Angela Sortino

17beta-estradiol rescues spinal motoneurons from AMPA-induced toxicity: a role for glial cells

scientific article

A major role for astrocytes in the neuroprotective effect of estrogen

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death.

scientific article published on 11 January 2011

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

scientific article

Adenosine deaminase increases release of excitatory amino acids through a mechanism independent of adenosine depletion ⬇️

scientific article published on February 1, 1991

Altered time course of changes in the hippocampal concentration of excitatory and inhibitory amino acids during kainate-induced epilepsy.

scientific article published in August 1984

Alzheimer's disease research enters a "new cycle": how significant?

scientific article

Alzheimer's disease: brain expression of a metabolic disorder?

scientific article published on 11 June 2010

Antidegenerative effects of Mg(2+)-valproate in cultured cerebellar neurons

scientific article published on 01 May 1995

Antiproliferative effects induced by guanine-based purines require hypoxanthine-guanine phosphoribosyltransferase activity.

scientific article published on September 2010

Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood-Brain Barrier Integrity

scientific article published on 21 November 2019

Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model

scientific article published on 23 July 2019

Astrocytes contribute to Aβ-induced blood-brain barrier damage through activation of endothelial MMP9.

scientific article published on 10 May 2017

Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway

scientific article published in January 2004

Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons

scientific article published on 01 May 2002

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

scientific article published on 17 January 2019

Cell cycle progression towards Alzheimer's disease.

scientific article

Changing hypothalamopituitary function: its role in aging of the female reproductive system

scientific article published on 01 January 1989

Comparative effects of eel calcitonin, salmon calcitonin and [Asu1,7]eel calcitonin on hypophyseal and osteoblastic function.

scientific article published in June 1993

Correction: Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model

scientific article published on 16 April 2020

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.

scientific article published in October 2006

Desensitization of metabotropic glutamate receptors in neuronal cultures.

scientific article published in April 1991

Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices.

scientific article published on September 1992

Different expression of TNF-alpha receptors and prostaglandin E(2 )Production in normal and fibrotic lung fibroblasts: potential implications for the evolution of the inflammatory process

scientific article published on 01 May 2000

Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging

scientific article published on 01 January 1996

Differential expression of estrogen receptors alpha and beta in the spinal cord during postnatal development: localization in glial cells

scientific article published in May 2003

Differential involvement of estrogen receptor alpha and estrogen receptor beta in the healing promoting effect of estrogen in human keratinocytes

scientific article

Dihydroergocryptine protects from acute experimental allergic encephalomyelitis in the rat

scientific article published on 01 May 1993

Distinct effects of pramipexole on the proliferation of adult mouse sub-ventricular zone-derived cells and the appearance of a neuronal phenotype

scientific article published on 25 January 2011

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

scientific article

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

scientific article published on 31 August 2011

Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?

article

Early β-Amyloid-induced Synaptic Dysfunction Is Counteracted by Estrogen in Organotypic Hippocampal Cultures.

scientific article

Effects of CDP-choline administration on receptor-stimulated inositol phospholipid hydrolysis in brain slices and neuronal cultures

scientific article published on July 1, 1992

Effects of phenformin on the proliferation of human tumor cell lines

scientific article published on December 2003

Enhanced expression of ERalpha in astrocytes modifies the response of cortical neurons to beta-amyloid toxicity.

scientific article

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

scientific article published on 18 October 2002

Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation.

scientific article

Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results.

scientific article published on 31 May 2017

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

scientific article published on 7 October 2011

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1.

scientific article published on 25 October 2016

Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model

article

Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.

scientific article

Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.

scientific article published on January 2014

Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.

scientific article published on 7 July 2008

Growth hormone releasing factor (GRF) increases free arachidonate levels in the pituitary: a role for lipoxygenase products.

scientific article published in January 1986

HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors.

scientific article published on 18 November 2014

High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4 in cultured keratinocytes.

scientific article published on 16 June 2015

Hyperalgesic activity of kisspeptin in mice.

scientific article published on 23 November 2011

Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity.

scientific article published on 30 October 2015

Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities

scientific article published on 6 September 2008

Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

scientific article

Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver

scientific article published on 01 September 1991

Integrins mediate beta-amyloid-induced cell-cycle activation and neuronal death.

scientific article published on February 2008

Involvement of norepinephrine activity in the regulation of alpha 1 adrenergic receptors in the medial preoptic nucleus of estradiol-treated rats

scientific article published on 01 January 1989

Ipriflavone inhibits phosphoinositide hydrolysis and Ca2+ uptake in the osteoblast-like UMR-106 cells

scientific article published on July 1, 1992

Linagliptin: A thorough Characterization beyond Its Clinical Efficacy

scientific article published on 26 February 2013

Long-term incubation with beta-amyloid peptides impairs endothelium-dependent vasodilatation in isolated rat basilar artery

scientific article published on 24 September 2009

Maitotoxin increases free calcium and inositol phosphates in rat anterior pituitary cells.

scientific article published in September 1990

Maitotoxin increases inositol phosphates in rat anterior pituitary cells

scientific article published on 01 February 1991

Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

scientific article published on 13 November 2018

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

scientific article published on 25 January 2012

Mitotic signaling by beta-amyloid causes neuronal death

scientific article published on 01 December 1999

Modulation of C6 Glioma Cell Proliferation by Ureido-Calix[8]arenes.

scientific article published on 18 August 2010

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target.

scientific article published on 10 February 2018

Neuroendocrine modulation of haloperidol-induced catalepsy

scientific article published on January 1983

Neuroprotective effect of insulin-like growth factor I in immortalized hypothalamic cells.

scientific article published on April 1996

Neurotensin stimulates polyphosphoinositide breakdown and prolactin release in anterior pituitary cells in culture.

scientific article published in October 1985

Neurotoxic properties of the anabolic androgenic steroids nandrolone and methandrostenolone in primary neuronal cultures

article

Neurotrophic factors, neuroprotection and hypothalamic function ⬇️

scientific article published on January 1, 1997

Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.

scientific article published on June 2005

Novel neuronal targets for the acetylcholinesterase inhibitor donepezil.

scientific article

Parathyroid hormone and arachidonate metabolism

scientific article

Protection by dihydroergocryptine of glutamate-induced neurotoxicity

scientific article published on 01 October 1993

Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons

scientific article published on 01 September 1994

Protein kinase C inhibits TRH-stimulated phosphoinositide hydrolysis in GH3 cells

scientific article published on 01 March 1987

Purinergic P2Y1 Receptors Control Rapid Expression of Plasma Membrane Processes in Hippocampal Astrocytes.

scientific article published on 18 June 2016

Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid

scientific article published on 03 July 2020

Relative contribution of different receptor subtypes in the response of neuroblastoma cells to tumor necrosis factor-alpha.

scientific article published on September 2000

Relaxin stimulates prolactin secretion from anterior pituitary cells

scientific article published on 01 April 1989

Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation

scientific article published on 12 September 2019

Role of the amygdala in the sedation induced by low doses of apomorphine

scientific article published on May 1983

SIRT1 Mediates Melatonin's Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence

scientific article published on 27 February 2020

Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death.

scientific article published on 9 November 2017

Specific binding sites for inositolhexakisphosphate in brain and anterior pituitary

scientific article published on 01 May 1990

TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.

scientific article

TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.

scientific article

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

scientific article

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

scientific article published on 15 December 2010

The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily.

scientific article

The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs

scientific article published on 01 April 2020

The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?

scientific article

The ambiguous role of microglia in Aβ toxicity: Chances for therapeutic intervention

scientific article published on 30 January 2020

The cell cycle molecules behind neurodegeneration in Alzheimer's disease: perspectives for drug development.

scientific article published on January 2008

The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death.

scientific article published on 8 May 2018

The lung as a privileged site for the beneficial actions of PGE2.

scientific article published on January 2004

The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death.

scientific article published on November 2006

β-amyloid and Oxidative Stress: Perspectives in Drug Development

scientific article published on 01 January 2019

‘Metabotropic’ glutamate receptors in rat hypothalamus: characterization and developmental profile ⬇️

scientific article published on August 19, 1991

Paulina is supported by:

About Paulina

Help