List of works - Gareth J Veal

13-cis retinoic acid and isomerisation in paediatric oncology--is changing shape the key to success?

scientific article

A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells

scientific article published on 08 April 2019

A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia

scientific article

A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin

scientific article

A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.

scientific article published on December 2016

Adaptive dosing and platinum-DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours.

scientific article published on 13 February 2007

Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma.

scientific article

Adaptive dosing of anticancer drugs in neonates: facilitating evidence-based dosing regimens.

scientific article

Biliary excretion of etoposide in children with cancer.

scientific article published on 18 January 2006

Busulfan pharmacokinetics following intravenous and oral dosing regimens in children receiving high-dose myeloablative chemotherapy for high-risk neuroblastoma as part of the HR-NBL-1/SIOPEN trial.

scientific article published on 26 June 2012

Carboplatin dosing in infants with retinoblastoma: a case for therapeutic drug monitoring.

scientific article published on 30 July 2012

Carboplatin therapeutic monitoring in preterm and full-term neonates.

scientific article

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

scientific article

Characterisation of the clinical pharmacokinetics of actinomycin D and the influence of ABCB1 pharmacogenetic variation on actinomycin D disposition in children with cancer

scientific article

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

scientific article published on 11 October 2012

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP‐glucuronosyltransferases ⬇️

scientific article published on February 1, 2011

Chemotherapy in newborns and preterm babies.

scientific article published on 28 March 2012

Chemotherapy individualization.

scientific article

Clinical pharmacology in the adolescent oncology patient

scientific article

Cyclophosphamide pharmacokinetics and pharmacogenetics in children with B-cell non-Hodgkin's lymphoma

scientific article published on 11 January 2016

Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography-mass spectrometry.

scientific article published in October 2003

Development and validation of LC-MS/MS with in-source collision-induced dissociation for the quantification of pegcantratinib in human skin tumors

scientific article published on 23 January 2017

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

scientific article published on 4 January 2016

Diverse assays from a single skin punch biopsy to assess topical drug intervention

scientific article published on 20 January 2019

Dosing of cancer patients with low or absent renal function

scientific article published on 01 March 2007

Drug interactions with zidovudine phosphorylation in vitro.

scientific article published in June 1995

Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells.

scientific article published on October 1994

Estimation of glomerular filtration rate in paediatric cancer patients using 51CR-EDTA population pharmacokinetics

scientific article published on January 2004

Estimation of renal function and its potential impact on carboplatin dosing in children with cancer

scientific article published on September 2008

Fundamental problems with pediatric adaptive dosing of carboplatin using nuclear-medicine-based estimates of renal function

scientific article published on 15 February 2019

Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial

scientific article published on 4 September 2017

Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

scientific article published on 17 January 2019

Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia-a report from the UKALL 2011 trial

scientific article published on 06 September 2019

In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

scientific article published on 12 August 2019

In vitro screening of nucleoside analog combinations for potential use in anti-HIV therapy

scientific article published on 01 April 1997

Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells

scientific article published on February 2005

Influence of cellular factors and pharmacokinetics on the formation of platinum-DNA adducts in leukocytes of children receiving cisplatin therapy

scientific article published on 01 August 2001

Institutional profile: pharmacogenomics research at Newcastle University.

scientific article published in September 2012

Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation

scientific article published on 01 May 1996

Intracellular activation of 2',3'-dideoxyinosine and drug interactions in vitro

scientific article

Investigating current practices in renal function measurement and carboplatin dosing in children with cancer - a UK perspective

scientific article published on 16 January 2020

Investigating the Experiences of Childhood Cancer Patients and Parents Participating in Optional Nontherapeutic Clinical Research Studies in the UK.

scientific article published on March 2016

Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence.

scientific article published on 12 January 2018

Investigating the roles and training of paediatric research nurses working across Europe: a questionnaire-based survey

scientific article published on 05 September 2017

Lamivudine (3TC) phosphorylation and drug interactions in vitro ⬇️

scientific article published on September 1, 1997

Malnourished Malawian patients presenting with large Wilms tumours have a decreased vincristine clearance rate

scientific article published on 09 April 2010

Metabolism of Zidovudine.

scientific article published on November 1995

Modulation of signaling enhances the efficacy of the combination of satraplatin and erlotinib

scientific article

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

scientific article published on 8 May 2007

Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells

scientific article

Novel micelles based on amphiphilic branched PEG as carriers for fenretinide

scientific article

Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold

scientific article

OP27ETOPOSIDE PHARMACOKINETICS FOLLOWING INTRA-CEREBROSPINAL FLUID ADMINISTRATION IN PATIENTS WITH LEPTOMENINGEAL METASTASES

Over a decade of experience with carboplatin therapeutic drug monitoring in a childhood cancer setting in the United Kingdom

scientific article published on 10 June 2020

Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste

scientific article published on 21 May 2019

Oxazaphosphorines: new therapeutic strategies for an old class of drugs

scientific article

P67DEFINING A TARGET INTRA-CEREBROSPINAL FLUID STEADY STATE ETOPOSIDE CONCENTRATION [CSF ETOPOSIDE] FOR PHASE I STUDY IN CHILDREN WITH LEPTOMENINGEAL METASTASIS (LM): INTREPID, A FIRST IN MAN STUDY

Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia

scientific article published on 05 January 2016

Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities

scientific article published on 01 April 2019

Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy

scientific article published on 04 May 2004

Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma - a study of the United Kingdom Children's Cancer Study Group.

scientific article published on 16 January 2007

Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2

scientific article published on 19 January 2016

Pharmacokinetics and pharmacogenetics of 13-cis retinoic acid in Indian high-risk neuroblastoma patients

scientific article published on 19 August 2016

Pharmacokinetics and pharmacogenetics of 13-cis-retinoic acid in the treatment of neuroblastoma

scientific article published on 01 March 2007

Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients

scientific article

Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition

scientific article published on 30 August 2019

Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function

scientific article published on 04 November 2018

Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma

scientific article published on 09 January 2019

Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells

scientific article

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

scientific article published on 26 April 2010

Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics

scientific article

Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies

scientific article

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

scientific article

Sequence-specific RNase H cleavage of gag mRNA from HIV-1 infected cells by an antisense oligonucleotide in vitro.

scientific article published on December 1998

Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates

scientific article published on 23 March 2011

Synergistic inhibition of HIV-1 by an antisense oligonucleotide and nucleoside analog reverse transcriptase inhibitors ⬇️

scientific article published on April 1, 1998

Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.

scientific article

Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).

scientific article

Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts.

scientific article

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

scientific article published on 01 October 2018

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

scientific article published on 01 April 2019

The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites

scientific article published on 01 October 1996

The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide

scientific article published on 29 September 2011

The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients

scientific article published on 30 August 2018

The use of pharmacokinetically guided carboplatin chemotherapy in a pre-term infant with neuroblastoma-associated spinal cord compression

scientific article published on 28 May 2019

Therapeutic drug monitoring and dose adaptation of cisplatin in a newborn with hepatoblastoma: a case report

scientific article published on 19 June 2018

Therapeutic drug monitoring in cancer--are we missing a trick?

scientific article

Therapeutic monitoring of carboplatin dosing in a premature infant with retinoblastoma.

scientific article published on 8 July 2008

Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues.

scientific article

Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients

scientific article published on 14 October 2021

Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers

scientific article published on 01 August 1994

List of works by Gareth J Veal

13-cis retinoic acid and isomerisation in paediatric oncology--is changing shape the key to success?

A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells

A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia

A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin

A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia.

Adaptive dosing and platinum-DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours.

Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma.

Adaptive dosing of anticancer drugs in neonates: facilitating evidence-based dosing regimens.

Biliary excretion of etoposide in children with cancer.

Busulfan pharmacokinetics following intravenous and oral dosing regimens in children receiving high-dose myeloablative chemotherapy for high-risk neuroblastoma as part of the HR-NBL-1/SIOPEN trial.

Carboplatin dosing in infants with retinoblastoma: a case for therapeutic drug monitoring.

Carboplatin therapeutic monitoring in preterm and full-term neonates.

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

Characterisation of the clinical pharmacokinetics of actinomycin D and the influence of ABCB1 pharmacogenetic variation on actinomycin D disposition in children with cancer

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP‐glucuronosyltransferases ⬇️

Chemotherapy in newborns and preterm babies.

Chemotherapy individualization.

Clinical pharmacology in the adolescent oncology patient

Cyclophosphamide pharmacokinetics and pharmacogenetics in children with B-cell non-Hodgkin's lymphoma

Determination of anti-cancer drug actinomycin D in human plasma by liquid chromatography-mass spectrometry.

Development and validation of LC-MS/MS with in-source collision-induced dissociation for the quantification of pegcantratinib in human skin tumors

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

Diverse assays from a single skin punch biopsy to assess topical drug intervention

Dosing of cancer patients with low or absent renal function

Drug interactions with zidovudine phosphorylation in vitro.

Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells.

Estimation of glomerular filtration rate in paediatric cancer patients using 51CR-EDTA population pharmacokinetics

Estimation of renal function and its potential impact on carboplatin dosing in children with cancer

Fundamental problems with pediatric adaptive dosing of carboplatin using nuclear-medicine-based estimates of renal function

Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial

Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia-a report from the UKALL 2011 trial

In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

In vitro screening of nucleoside analog combinations for potential use in anti-HIV therapy

Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells

Influence of cellular factors and pharmacokinetics on the formation of platinum-DNA adducts in leukocytes of children receiving cisplatin therapy

Institutional profile: pharmacogenomics research at Newcastle University.

Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation

Intracellular activation of 2',3'-dideoxyinosine and drug interactions in vitro

Investigating current practices in renal function measurement and carboplatin dosing in children with cancer - a UK perspective

Investigating the Experiences of Childhood Cancer Patients and Parents Participating in Optional Nontherapeutic Clinical Research Studies in the UK.

Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence.

Investigating the roles and training of paediatric research nurses working across Europe: a questionnaire-based survey

Lamivudine (3TC) phosphorylation and drug interactions in vitro ⬇️

Malnourished Malawian patients presenting with large Wilms tumours have a decreased vincristine clearance rate

Metabolism of Zidovudine.

Modulation of signaling enhances the efficacy of the combination of satraplatin and erlotinib

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.

Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells

Novel micelles based on amphiphilic branched PEG as carriers for fenretinide

Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold

OP27ETOPOSIDE PHARMACOKINETICS FOLLOWING INTRA-CEREBROSPINAL FLUID ADMINISTRATION IN PATIENTS WITH LEPTOMENINGEAL METASTASES

Over a decade of experience with carboplatin therapeutic drug monitoring in a childhood cancer setting in the United Kingdom

Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste

Oxazaphosphorines: new therapeutic strategies for an old class of drugs

P67DEFINING A TARGET INTRA-CEREBROSPINAL FLUID STEADY STATE ETOPOSIDE CONCENTRATION [CSF ETOPOSIDE] FOR PHASE I STUDY IN CHILDREN WITH LEPTOMENINGEAL METASTASIS (LM): INTREPID, A FIRST IN MAN STUDY

Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia

Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities

Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy

Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma - a study of the United Kingdom Children's Cancer Study Group.

Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2

Pharmacokinetics and pharmacogenetics of 13-cis retinoic acid in Indian high-risk neuroblastoma patients

Pharmacokinetics and pharmacogenetics of 13-cis-retinoic acid in the treatment of neuroblastoma

Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients

Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition

Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function

Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma

Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells

Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics

Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

Sequence-specific RNase H cleavage of gag mRNA from HIV-1 infected cells by an antisense oligonucleotide in vitro.

Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates

Synergistic inhibition of HIV-1 by an antisense oligonucleotide and nucleoside analog reverse transcriptase inhibitors ⬇️

Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.

Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).

Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts.