List of works - Jacob I Ayers

Coinfecting prion strains compete for a limiting cellular resource

scientific article

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

scientific article

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice

scientific article

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease

scientific article published on 21 October 2013

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

scientific article published on 07 March 2019

Experimental transmissibility of mutant SOD1 motor neuron disease

scientific article published on 28 September 2014

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

scientific article

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

scientific article published in PLoS ONE

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

scientific article published on 3 October 2017

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

scientific article published on 5 November 2015

Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

scientific article published on 15 September 2020

Prion interference is due to a reduction in strain-specific PrPSc levels

scientific article published on November 2006

Prion strain targeting independent of strain-specific neuronal tropism

scientific article published on 29 October 2008

Prion-like mechanisms in amyotrophic lateral sclerosis

scientific article published on 01 January 2018

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

scientific article

Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice

scientific article published on 06 July 2016

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

scientific article

The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease

scientific article (publication date: March 2011)

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

scientific article published on 30 January 2020

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.

scientific article published on 17 September 2014

List of works by Jacob I Ayers

Coinfecting prion strains compete for a limiting cellular resource

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Experimental transmissibility of mutant SOD1 motor neuron disease

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

Prion interference is due to a reduction in strain-specific PrPSc levels

Prion strain targeting independent of strain-specific neuronal tropism

Prion-like mechanisms in amyotrophic lateral sclerosis

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.