List of works - Jesús F Aparicio

A Streptomyces glaucescens endodeoxyribonuclease which shows a strong preference for CC dinucleotide

scientific article

A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis ⬇️

scientific article

Activation of Secondary Metabolite Gene Clusters in by the PimM Regulator of ⬇️

article

An efficient gene transfer system for the pimaricin producer Streptomyces natalensis. ⬇️

scientific article

Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.

scientific article

Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.

scientific article

Characterization of the ask-asd operon in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.

scientific article published on 11 October 2003

Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme.

scientific article

Cholesterol Oxidases Act as Signaling Proteins for the Biosynthesis of the Polyene Macrolide Pimaricin

scientific article published on 01 March 2007

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

article

Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain.

scientific article

Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).

scientific article

Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis. ⬇️

scientific article published in July 2001

Enzymology of the polyenes pimaricin and candicidin biosynthesis.

scientific article

Evidence for a double-helical structure for modular polyketide synthases.

scientific article published on February 1996

Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives ⬇️

scientific article

Functional analysis of pneumolysin by use of monoclonal antibodies

scientific article

Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis

scientific article

Generating novel polyene antifungal drugs.

scientific article

Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.

scientific article published on 11 January 2014

Glycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetes

scientific article published on 01 October 2006

Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.

scientific article published on 5 June 2012

LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor ⬇️

scientific article

Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.

scientific article published on 27 December 2010

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

scientific article

PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis.

scientific article

PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis.

scientific article

Pathway-specific regulation revisited: cross-regulation of multiple disparate gene clusters by PAS-LuxR transcriptional regulators

scientific article published on 26 February 2015

Phosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factor

scientific article published in PLoS ONE

PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

scientific article published in September 2007

Polyene antibiotic biosynthesis gene clusters.

scientific article

Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein-Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis.

scientific article published on 2 March 2018

Purification and characterization of a nutritionally controlled endodeoxyribonuclease from Streptomyces glaucescens ⬇️

scientific article published on January 1, 1992

Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331.

scientific article

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

scientific article

Structural and Bioactivity Characterization of Filipin Derivatives from Engineered Streptomyces filipinensis Strains Reveals Clues for Reduced Haemolytic Action

scientific article published on 16 July 2020

Structure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric Intermediate

scientific article

The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.

scientific article published in April 1999

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

scientific article

The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.

scientific article published on 24 October 2006

List of works by Jesús F Aparicio

A Streptomyces glaucescens endodeoxyribonuclease which shows a strong preference for CC dinucleotide

A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis ⬇️

Activation of Secondary Metabolite Gene Clusters in by the PimM Regulator of ⬇️

An efficient gene transfer system for the pimaricin producer Streptomyces natalensis. ⬇️

Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.

Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.

Characterization of the ask-asd operon in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.

Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme.

Cholesterol Oxidases Act as Signaling Proteins for the Biosynthesis of the Polyene Macrolide Pimaricin

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain.

Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).

Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis. ⬇️

Enzymology of the polyenes pimaricin and candicidin biosynthesis.

Evidence for a double-helical structure for modular polyketide synthases.

Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives ⬇️

Functional analysis of pneumolysin by use of monoclonal antibodies

Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis

Generating novel polyene antifungal drugs.

Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.

Glycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetes

Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.

LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor ⬇️

Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis.

PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis.

Pathway-specific regulation revisited: cross-regulation of multiple disparate gene clusters by PAS-LuxR transcriptional regulators

Phosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factor

PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

Polyene antibiotic biosynthesis gene clusters.

Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein-Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis.

Purification and characterization of a nutritionally controlled endodeoxyribonuclease from Streptomyces glaucescens ⬇️

Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331.

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

Structural and Bioactivity Characterization of Filipin Derivatives from Engineered Streptomyces filipinensis Strains Reveals Clues for Reduced Haemolytic Action

Structure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric Intermediate

The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.