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List of works by John F Engelhardt

A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma

scientific article

A Mutation in the Srrm4 Gene Causes Alternative Splicing Defects and Deafness in the Bronx Waltzer Mouse ⬇️

scientific article published on October 4, 2012

A Preclinical Study in Rhesus Macaques for Cystic Fibrosis to Assess Gene Transfer and Transduction by AAV1 and AAV5 with a Dual-Luciferase Reporter System.

scientific article published on 20 July 2017

A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret

scientific article

A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling

scientific article published on 10 February 2016

A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia.

scientific article published on 30 July 2013

AAV hits the genomic bull's-eye.

scientific article

AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR.

scientific article published on 5 July 2017

Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis.

scientific article published on 22 July 2016

Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets.

scientific article

Adenovirus-mediated gene transfer to human bronchial submucosal glands using xenografts.

scientific article published in April 1995

Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells.

scientific article published in December 1997

Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study.

scientific article published in December 1993

Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation.

scientific article

Airway epithelial cells: current concepts and challenges.

scientific article published on September 2008

Airway glandular development and stem cells.

scientific article

Airway surface fluid volume and Cl content in cystic fibrosis and normal bronchial xenografts

scientific article published on 01 February 1999

Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity

scientific article published on 20 September 2011

Analysis of adeno-associated virus progenitor cell transduction in mouse lung.

scientific article

Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome.

scientific article published on 22 June 2016

Animal and model systems for studying cystic fibrosis

scientific article published on 19 September 2017

Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size

scientific article published on 11 April 2018

At least two mutant alleles of ornithine delta-aminotransferase cause gyrate atrophy of the choroid and retina in Finns.

scientific article

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes ⬇️

scientific article published on May 1, 2003

Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates.

scientific article

CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors

scientific article

CFTR does not alter acidification of L cell endosomes.

scientific article published on November 1994

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes

scientific article published on 08 September 2016

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice

scientific article published on 01 May 2015

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice.

scientific article

Cellular heterogeneity of CFTR expression and function in the lung: implications for gene therapy of cystic fibrosis.

scientific article published in January 1998

Chromatin configurations in the ferret germinal vesicle that reflect developmental competence for in vitro maturation.

scientific article published on 10 September 2008

Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

scientific article published on November 2016

Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Cloned ferrets produced by somatic cell nuclear transfer

scientific article

Cloning and identification of microRNAs in bovine alveolar macrophages.

scientific article

Comparative biology of cystic fibrosis animal models

scientific article published on January 2011

Comparative biology of rAAV transduction in ferret, pig and human airway epithelia.

scientific article published on 30 August 2007

Comparative processing and function of human and ferret cystic fibrosis transmembrane conductance regulator.

scientific article

Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination.

scientific article

Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4

scientific article

Coupled secretion of chloride and mucus in skin of Xenopus laevis: possible role for CFTR

scientific article published on 01 August 1994

Current status of gene therapy for inherited lung diseases

scientific article

Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor

scientific article

DEVELOPMENT OF A POLARIZED PANCREATIC DUCTULAR CELL EPITHELIA FOR PHYSIOLOGICAL STUDIES.

scientific article published on 8 March 2018

DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells

scientific article

Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs

scientific article published in June 2015

Definitive localization of intracellular proteins: Novel approach using CRISPR-Cas9 genome editing, with glucose 6-phosphate dehydrogenase as a model

scientific article

Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis

scientific article published on 01 April 2018

Developmental capacity of ferret embryos by nuclear transfer using G0/G1-phase fetal fibroblasts.

scientific article published on 5 February 2003

Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway.

scientific article published on March 2001

Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses.

scientific article published on May 1993

Directing integrin-linked endocytosis of recombinant AAV enhances productive FAK-dependent transduction.

scientific article published on 10 January 2012

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.

scientific article

Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia ⬇️

scientific article published on June 14, 2012

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.

scientific article published on 15 June 2016

Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway.

scientific article published on 13 October 2009

Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.

scientific article published in December 2004

Dual vector expansion of the recombinant AAV packaging capacity.

scientific article published on January 2003

Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells.

scientific article published in September 1999

Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.

scientific article published in February 2003

Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury

scientific journal article

Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha

scientific article

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

scientific article

Endothelin-1 Stimulates Arterial VCAM-1 Expression Via NADPH Oxidase-Derived Superoxide in Mineralocorticoid Hypertension ⬇️

scientific article published on September 29, 2003

Enhancement of muscle gene delivery with pseudotyped adeno-associated virus type 5 correlates with myoblast differentiation.

scientific article published on August 2001

Epithelial sodium channels regulate cystic fibrosis transmembrane conductance regulator chloride channels in Xenopus oocytes.

scientific article published in May 2000

Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia ⬇️

scientific article published on August 30, 2012

Evidence for a superoxide permeability pathway in endosomal membranes

scientific article published on 31 March 2008

Expression of c-fos and c-jun during hepatocellular remodeling following ischemia/reperfusion in mouse liver.

scientific article published in June 1996

Expression of the cystic fibrosis gene in adult human lung

scientific article

Factors affecting the efficiency of embryo transfer in the domestic ferret (Mustela putorius furo)

scientific article published on 5 December 2005

Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy

scientific article

Ferret lung transplant: an orthotopic model of obliterative bronchiolitis.

scientific article published on 3 December 2012

Formation of adeno-associated virus circular genomes is differentially regulated by adenovirus E4 ORF6 and E2a gene expression.

scientific article published on January 1999

Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report

scientific article

Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets.

scientific article published on 15 March 2014

Gene delivery to the airway

scientific article published on July 2013

Gene delivery to the airway

scientific article published on 01 May 2001

Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill.

scientific article published on May 1994

Gene therapy of cystic fibrosis lung disease

scientific article published on February 1, 1992

Genotypic analysis of respiratory mucous sulfation defects in cystic fibrosis.

scientific article published on December 1995

Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance.

scientific article published on 3 September 2015

Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.

scientific article

Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner

scientific article published on 02 May 2013

Human Bocavirus 1 Is a Novel Helper for Adeno-Associated Virus Replication.

scientific article published on 28 June 2017

Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes

scientific article published on 10 May 2017

Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death via Inhibiting Apoptosis.

scientific article published on 11 October 2017

Human distal airways contain a multipotent secretory cell that can regenerate alveoli

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

scientific article

Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo.

scientific article

Identification and Functional Analysis of Novel Nonstructural Proteins of Human Bocavirus 1.

scientific article

Immunohistochemical demonstration of airway epithelial cell markers of Guinea pig ⬇️

scientific article published on June 25, 2011

In situ hybridization of SP-A mRNA in adult human conducting airways

scientific article published on 01 September 2001

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

scientific article published on 01 March 2019

In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia.

scientific article published on 23 January 2013

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.

scientific article published in July 1994

Incorporation of adeno-associated virus in a calcium phosphate coprecipitate improves gene transfer to airway epithelia in vitro and in vivo.

scientific article

Indexing TNF-alpha gene expression using a gene-targeted reporter cell line

scientific article

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans ⬇️

scientific article published on October 27, 1994

Infection is Not Required for Mucoinflammatory Lung Disease in CFTR-knockout Ferrets

scientific article published on 12 January 2018

Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats.

scientific article

Intracellular trafficking of adeno-associated viral vectors.

scientific article

Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis.

scientific article published in January 1999

Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes

scientific article

Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation

scientific article

Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation

scientific article published on 01 October 1998

IκBα and IκBβpossess injury context–specific functions that uniquely influence hepatic NF-κB induction and inflammation

scholarly article by Chenguang Fan et al published 1 February 2005 in Journal of Clinical Investigation

JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation

scientific article published on 8 January 2008

Lef1 Transcription Factor Expression Defines Airway Progenitor Cell Targets for In Utero Gene Therapy of Submucosal Gland in Cystic Fibrosis ⬇️

scientific article published on June 1, 1998

Longitudinal noninvasive monitoring of transcription factor activation in cardiovascular regulatory nuclei using bioluminescence imaging

scientific article published on 29 January 2008

Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets.

scientific article

Lysozyme secretion by submucosal glands protects the airway from bacterial infection.

scientific article published on 3 March 2005

MUC5B and MUC7 Are Differentially Expressed in Mucous and Serous Cells of Submucosal Glands in Human Bronchial Airways ⬇️

scientific article published on July 1, 1998

Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity.

scientific article published on March 1998

Mechanisms of submucosal gland morphogenesis in the airway.

scientific article

Methods for adenovirus-mediated gene transfer to airway epithelium

scientific article published in January 1997

Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR ⬇️

scientific article published on August 1, 1993

Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development

scientific article published on 26 January 2017

NADPH Oxidases Are Essential for Macrophage Differentiation

scientific article published on 3 August 2016

New animal models of cystic fibrosis: what are they teaching us?

scientific article published on November 2011

New models of the tracheal airway define the glandular contribution to airway surface fluid and electrolyte composition.

scientific article

New technologies for genetic manipulation of animal models: Forum introduction

scientific article

Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells ⬇️

scientific article published on October 1, 1998

Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins

scientific article published on 24 February 2016

Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes

scientific article

Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy.

scientific article published on 2 May 2006

Nuclear transfer of M-phase ferret fibroblasts synchronized with the microtubule inhibitor demecolcine.

scientific article published in December 2005

Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers

scientific article published on 20 April 2015

Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells

scientific article published on September 1999

Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells.

scientific article published in June 1998

PITX2 and beta-catenin interactions regulate Lef-1 isoform expression.

scientific article

PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter

scientific article

Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets

scientific article published on 20 January 2018

Pancreatic pathophysiology in cystic fibrosis

scientific article

Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

scientific article published on 01 January 2002

Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication

scientific article published on 25 January 2017

Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS.

scientific article

Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia.

scientific article

Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions.

scientific article published on September 2013

Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy.

scientific article

Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer

scientific article

Progenitor cells in proximal airway epithelial development and regeneration

scientific article

Progenitor cells of the adult human airway involved in submucosal gland development.

scientific article published in July 1995

Progress and prospects: techniques for site-directed mutagenesis in animal models.

scientific article

Progress toward generating a ferret model of cystic fibrosis by somatic cell nuclear transfer

scientific article

Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a.

scientific article published in October 1994

Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins

scientific article published on 23 February 2015

Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets

scientific article

Rate limiting steps of AAV transduction and implications for human gene therapy.

scientific article

Real-Time Monitoring of Insulin Using a Graphene Field-Effect Transistor Aptameric Nanosensor.

scientific article

Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction ⬇️

scientific article published on December 1, 1997

Recombinant AAV-mediated gene delivery using dual vector heterodimerization.

scientific article published on January 2002

Reconstitution of tracheal grafts with a genetically modified epithelium ⬇️

scientific article published on December 15, 1991

Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation.

scientific article

Redox modifier genes in amyotrophic lateral sclerosis in mice.

scientific article

Redox-modulating gene therapies for human diseases

scientific article published on 01 June 2001

Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways

scientific article published on 14 January 2016

Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function.

scientific article published on September 2008

Retroviral gene transfer into rat tracheal grafts

scientific article published on 01 March 1992

Retrovirus vector-targeted inducible expression of human beta-interferon gene to B-cells.

scientific article published on October 1990

Selective suppression of cervical cancer Hela cells by 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from the fruit of Lycium barbarum L.

scientific article published on 19 August 2010

Signaling components of redox active endosomes: the redoxosomes.

scientific article

Signaling role of intracellular iron in NF-kappaB activation

scientific article published on 11 March 2003

Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter.

scientific article

Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal.

scientific article published on 22 September 2016

Sox2 modulates Lef-1 expression during airway submucosal gland development.

scientific article published on 31 January 2014

Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD

scientific article published on 01 December 2004

Stem cell niches in the mouse airway.

scientific article published in June 2001

Stem cells in the lung.

scientific article published on January 2006

Structural analysis of adeno-associated virus transduction circular intermediates.

scientific article published in August 1999

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium

scientific article published on 12 April 2018

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.

scientific article

Submucosal glands are the predominant site of CFTR expression in the human bronchus

scientific article published on 01 November 1992

Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia.

scientific article

The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies

scientific article published on 04 March 2014

The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease

scientific article (publication date: December 2014)

The glandular stem/progenitor cell niche in airway development and repair.

scientific article published on August 2008

The lung as a metabolic factory for gene therapy.

scientific article

The porcine lung as a potential model for cystic fibrosis

scientific article published on 16 May 2008

The role of LEF1 in endometrial gland formation and carcinogenesis

scientific article

Therapeutic approaches for ischemia/reperfusion injury in the liver.

scientific article

Trans-splicing vectors expand the packaging limits of adeno-associated virus for gene therapy applications.

scientific article published on January 2003

Transcriptional analysis of the human ornithine aminotransferase promoter ⬇️

scientific article published on January 15, 1991

Transfer of the CFTR Gene to the Lung of Nonhuman Primates with E1-Deleted, E2a-Defective Recombinant Adenoviruses: A Preclinical Toxicology Study ⬇️

scientific article published on July 1, 1995

Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.

scientific article published on 11 November 2002

Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors.

scientific article published on March 2002

Ultrastructural localization of variant forms of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial of xenografts.

scientific article published on July 1994

Unique biologic properties of recombinant AAV1 transduction in polarized human airway epithelia.

scientific article

Unique characteristics of AAV1, 2, and 5 viral entry, intracellular trafficking, and nuclear import define transduction efficiency in HeLa cells.

scientific article published on 28 June 2011

Validation of a radioimmunoassay of serum trypsin-like immunoreactivity in ferrets

scientific article published on 02 May 2018

Vector-Specific Complementation Profiles of Two Independent Primary Defects in Cystic Fibrosis Airways ⬇️

scholarly article by Y Zhang et al published 20 March 1998 in Human Gene Therapy

Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size.

scientific article

Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands

scientific article published on 24 June 2016

Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.

scientific article

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.

scientific article published on 7 February 2007

Xenograft model of the CF airway.

scientific article published in January 2002

rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion

scientific article published on 25 January 2006

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