List of works - Gareth J Jenkins

A Newly Developed Nested PCR Assay for the Detection of Helicobacter pylori in the Oral Cavity.

scientific article published on 24 March 2015

A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity

scientific article published on 26 July 2016

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells.

scientific article published on 6 November 2017

A study of ENU-induced mutagenesis in the mouse using the restriction site mutation (RSM) assay

scientific article published on 01 January 1999

A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies.

scientific article published on 15 December 2017

Acute dosing and p53-deficiency promote cellular sensitivity to DNA methylating agents.

scientific article

An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health

scientific article published on 05 August 2020

Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridization

scientific article

Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer.

scientific article published on 27 May 2009

Application of the restriction site mutation technique toN-methyl-N-nitrosourea-induced mutations in the rat ⬇️

scientific article published on January 1, 1998

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.

scientific article published on 27 March 2014

Barrett's esophagus: prevalence-incidence and etiology-origins

scientific article published in September 2011

Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints ⬇️

scientific article

Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma.

scientific article published on November 2003

Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus.

scientific article published on May 2003

Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent

scientific article published on 27 March 2014

Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease.

scientific article published on 11 October 2017

Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity

scientific article

Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett's oesophagus.

scientific article

DNA hypermethylation as a predictor of extramural vascular invasion (EMVI) in rectal cancer.

scientific article published on 20 December 2017

Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: The potential role of anti-oxidants in Barrett's oesophagus

scientific article published on 11 August 2006

Detection of p53 mutations in precancerous gastric tissue ⬇️

scientific article published on October 6, 2003

Developing a blood-based gene mutation assay as a novel biomarker for oesophageal adenocarcinoma

article

Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.

scientific article

Do dose response thresholds exist for genotoxic alkylating agents?

scientific article

Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology.

scientific article published on April 2003

Enhanced restriction site mutation (RSM) analysis of 1,2-dimethylhydrazine induced mutations, using endogenous p53 intron sequences.

scientific article published on May 1997

Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and may represent a biomarker of histological progression in Barrett's esophagus (BE).

scientific article

Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.

scientific article

Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma.

scientific article published on 27 January 2009

Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia

scientific article

Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype.

scientific article

Generation of locus-specific probes for interphase fluorescence in situ hybridisation--application in Barrett's esophagus.

scientific article

Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer

scientific article

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™) ⬇️

scientific article

Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries ⬇️

scientific article published on 14 August 2015

Genotoxic thresholds, DNA repair, and susceptibility in human populations.

scientific article

Genotoxins induce binucleation in L5178Y and TK6 cells

scientific article

Genotypic mutation analysis in the p53 gene of benzo[a]pyrene-treated European flounder (Platichthys flesus)

scientific article published on 01 June 2000

Human papillomavirus infection in Barrett's oesophagus in the UK: an infrequent event.

scientific article published on 21 August 2008

Immunohistochemical study of nuclear factor-kappaB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers.

scientific article published on 12 January 2007

In vitro and ex vivo models of extended reflux exposure demonstrate that weakly acidic mixed reflux heightens NF-kB-mediated gene expression.

scientific article published on 10 December 2010

In vitro and in vivo extrapolations of genotoxin exposures: consideration of factors which influence dose-response thresholds

scientific article published on 01 January 2000

In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials

scientific article published on 13 February 2019

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines ⬇️

scientific article published on September 28, 2011

Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) are important mediators of reflux-induced cell signalling in esophageal cells.

scientific article

Inverse restriction site mutation (iRSM) analysis. Mutation detection involving the formation of restriction enzyme sites in target genes

scientific article published on 01 January 1999

Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro

article

Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N-methyl-N-nitrosourea

scientific article

Is Nickel Chloride really a Non-Genotoxic Carcinogen?

scientific article

Molecular changes consistent with increased proliferation and invasion are common in rectal cancer.

scientific article published in October 2011

Mutation analysis using the restriction site mutation (RSM) assay

scientific article published on 01 September 1998

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage

scientific article published on 11 November 2010

NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.

scientific article published on 08 May 2009

No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

scientific article

Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis

scientific article

PCR-based methodology for the determination of the photoprotection afforded by sunscreen application

scientific article published on 01 December 2000

Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

scientific article

Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study

scientific article published on 18 October 2018

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

scientific article published on 4 April 2014

Reflux composition influences the level of NF-κB activation and upstream kinase preference in oesophageal adenocarcinoma cells

scientific article

Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study.

scientific article published in April 2008

Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies

scientific article published on 18 August 2018

Restriction site mutation (RSM) analysis of 2-acetylaminofluorene (2-AAF)-induced mouse liver mutations and comparison with the measurement of in vivo micronucleus induction in the bone marrows of (2-AAF)-treated mice

scientific article published on 01 January 2000

Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer.

scientific article published on 22 July 2015

Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties.

scientific article published on 20 January 2012

The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS.

scientific article

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

scientific article

The detection of mutations induced in vitro in the human p53 gene by hydrogen peroxide with the restriction site mutation (RSM) assay.

scientific article

The jury is still out on the safety of silver nanoparticles

scientific article

The polymerase inhibition assay: A methodology for the identification of DNA-damaging agents.

scientific article

The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile

scientific article

The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles.

scientific article

The role of secondary bile acids in neoplastic development in the oesophagus.

scientific article published on April 2010

Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487.

scientific article published on 8 August 2009

List of works by Gareth J Jenkins

A Newly Developed Nested PCR Assay for the Detection of Helicobacter pylori in the Oral Cavity.

A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells.

A study of ENU-induced mutagenesis in the mouse using the restriction site mutation (RSM) assay

A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies.

Acute dosing and p53-deficiency promote cellular sensitivity to DNA methylating agents.

An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health

Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridization

Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer.

Application of the restriction site mutation technique toN-methyl-N-nitrosourea-induced mutations in the rat ⬇️

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.

Barrett's esophagus: prevalence-incidence and etiology-origins

Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints ⬇️

Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma.

Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus.

Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent

Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease.

Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity

Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett's oesophagus.

DNA hypermethylation as a predictor of extramural vascular invasion (EMVI) in rectal cancer.

Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: The potential role of anti-oxidants in Barrett's oesophagus

Detection of p53 mutations in precancerous gastric tissue ⬇️

Developing a blood-based gene mutation assay as a novel biomarker for oesophageal adenocarcinoma

Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.

Do dose response thresholds exist for genotoxic alkylating agents?

Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology.

Enhanced restriction site mutation (RSM) analysis of 1,2-dimethylhydrazine induced mutations, using endogenous p53 intron sequences.

Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and may represent a biomarker of histological progression in Barrett's esophagus (BE).

Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.

Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma.

Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia

Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype.

Generation of locus-specific probes for interphase fluorescence in situ hybridisation--application in Barrett's esophagus.

Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™) ⬇️

Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries ⬇️

Genotoxic thresholds, DNA repair, and susceptibility in human populations.

Genotoxins induce binucleation in L5178Y and TK6 cells

Genotypic mutation analysis in the p53 gene of benzo[a]pyrene-treated European flounder (Platichthys flesus)

Human papillomavirus infection in Barrett's oesophagus in the UK: an infrequent event.

Immunohistochemical study of nuclear factor-kappaB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers.

In vitro and ex vivo models of extended reflux exposure demonstrate that weakly acidic mixed reflux heightens NF-kB-mediated gene expression.

In vitro and in vivo extrapolations of genotoxin exposures: consideration of factors which influence dose-response thresholds

In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines ⬇️

Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) are important mediators of reflux-induced cell signalling in esophageal cells.

Inverse restriction site mutation (iRSM) analysis. Mutation detection involving the formation of restriction enzyme sites in target genes

Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro

Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N-methyl-N-nitrosourea

Is Nickel Chloride really a Non-Genotoxic Carcinogen?

Molecular changes consistent with increased proliferation and invasion are common in rectal cancer.

Mutation analysis using the restriction site mutation (RSM) assay

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage

NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.

No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis

PCR-based methodology for the determination of the photoprotection afforded by sunscreen application

Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

Reflux composition influences the level of NF-κB activation and upstream kinase preference in oesophageal adenocarcinoma cells

Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study.

Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies

Restriction site mutation (RSM) analysis of 2-acetylaminofluorene (2-AAF)-induced mouse liver mutations and comparison with the measurement of in vivo micronucleus induction in the bone marrows of (2-AAF)-treated mice

Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer.

Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties.

The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS.

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

The detection of mutations induced in vitro in the human p53 gene by hydrogen peroxide with the restriction site mutation (RSM) assay.

The jury is still out on the safety of silver nanoparticles

The polymerase inhibition assay: A methodology for the identification of DNA-damaging agents.

The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile

The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles.

The role of secondary bile acids in neoplastic development in the oesophagus.

Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487.