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List of works by Karen J Shaw

A novel family of Escherichia coli toxin-antitoxin gene pairs

scientific article published on November 2003

Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome

scientific article

Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium.

scientific article

Analysis of beta-glucans and chitin in a Saccharomyces cerevisiae cell wall mutant using high-performance liquid chromatography.

scientific article published in August 1994

Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase.

scientific article

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus

scientific article

Comparison of the changes in global gene expression of Escherichia coli induced by four bactericidal agents.

scientific article published in January 2003

Correlation between aminoglycoside resistance profiles and DNA hybridization of clinical isolates.

scientific article published on November 1991

Determination of aminoglycoside resistance mechanisms of Enterobacteriaceae isolated from a hospital in Hong Kong with antibiogram and genotyping.

scientific article

Diversity of aminoglycoside resistance in Enterobacter cloacae in Greece

scientific article published on February 1, 1992

Elevated Linezolid Resistance in Clinical cfr -Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3 ⬇️

scientific article published on September 13, 2010

Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis.

scientific article published on 5 March 2007

Evernimicin (SCH27899) inhibits a novel ribosome target site: analysis of 23S ribosomal DNA mutants.

scientific article published on November 2000

Genetic Environment and Stability of cfr in Methicillin-Resistant Staphylococcus aureus CM05 ⬇️

scientific article published on October 24, 2011

Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins ⬇️

scientific article published on May 1, 1992

Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center

scientific article published on 18 August 2014

Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design

scientific article

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.

scientific article published on 12 June 2013

In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.

scientific article published on 6 October 2008

In vitro and in vivo Evaluation of the Antifungal Activity of APX001A/APX001 Against Candida auris

scientific article published on 8 January 2018

Low Fitness Cost of the Multidrug Resistance Gene cfr ⬇️

scientific article published on June 6, 2011

Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action.

scientific article

Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.

scientific article published on 5 October 2009

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis

scientific article published on 06 March 2007

Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).

scientific article published on 14 September 2009

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.

scientific article published on 8 December 2012

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

scientific article

Regulated secretion of MuGM-CSF in Saccharomyces cerevisiae via GAL1:MF alpha 1 prepro sequences

scientific article published on 01 March 1988

Results of the surveillance of Tedizolid activity and resistance program: in vitro susceptibility of gram-positive pathogens collected in 2011 and 2012 from the United States and Europe.

scientific article published on 30 August 2014

Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment

scientific article published on 01 September 2004

Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.

scientific article published on 13 September 2010

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines

scientific article

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines

scientific article

Tedizolid for the management of human infections: in vitro characteristics.

scientific article published on January 2014

Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains

scientific article published on 06 March 2007

The oxazolidinones: past, present, and future.

scientific article published on December 2011

Transcriptional profiling and drug discovery.

scientific article published on October 2003

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents

scientific article (publication date: 2013)

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