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List of works by Tadashi Eguchi

23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone.

scientific article

A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics

scientific article published on 25 October 2011

A Unique Amino Transfer Mechanism for Constructing the β-Amino Fatty Acid Starter Unit in the Biosynthesis of the Macrolactam Antibiotic Cremimycin

scientific article published on 06 September 2013

A Unique Pathway for the 3-Aminobutyrate Starter Unit from l-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine

scientific article published on 28 August 2012

A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and 1H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase.

scientific article

A new family of glucose-1-phosphate/glucosamine-1-phosphate nucleotidylyltransferase in the biosynthetic pathways for antibiotics.

scientific article

A new method for enzymatic preparation of isopentenyladenine-type and trans-zeatin-type cytokinins with radioisotope-labeling

scientific article published in May 2003

A novel ether core lipid with H-shaped C80-isoprenoid hydrocarbon chain from the hyperthermophilic methanogen Methanothermus fervidus.

scientific article published in February 1998

A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.

scientific article published on 6 June 2013

Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs

scientific article published on 12 October 2015

An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

scientific article published on 23 April 2019

Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis

scientific article published on 06 April 2020

Biochemical characterization and structural insight into aliphatic β-amino acid adenylation enzymes IdnL1 and CmiS6.

scientific article

Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum

scientific article published on 01 June 2006

Biosynthesis of natural products containing β-amino acids.

scientific article

C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration

scientific article published on 12 July 2018

Carbon-free production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus PCC 7942.

scientific article published on 3 January 2018

Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin

scientific article published on 01 January 2009

Characterization of Radical SAM Adenosylhopane Synthase, HpnH, which Catalyzes the 5'-Deoxyadenosyl Radical Addition to Diploptene in the Biosynthesis of C35 Bacteriohopanepolyols

scientific article published on 19 November 2019

Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis

scholarly article by Fumitaka Kudo et al published 17 September 2014 in Journal of the American Chemical Society

Characterization of polyphosphate glucokinase SCO5059 from Streptomyces coelicolor A3(2).

scientific article published on 7 November 2013

Coenzyme Activity of NAD Analogs for 3-Isopropylmalate Dehydrogenase from Thermus thermophilus HB8

scientific article published on 01 January 1999

Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor

scientific article

Crystallization and X-ray analysis of 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics.

scientific article

Crystallization and preliminary X-ray analysis of isopentenyl diphosphate isomerase from Methanocaldococcus jannaschii.

scientific article published on 23 December 2010

Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster

article

Enzymatic preparation of neomycin C from ribostamycin.

scientific article published on 28 August 2009

Epimerization at C-3′′ in Butirosin Biosynthesis by an NAD+-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF

scientific article published on 19 January 2015

Five-Membered Cyclitol Phosphate Formation by a myo-Inositol Phosphate Synthase Orthologue in the Biosynthesis of the Carbocyclic Nucleoside Antibiotic Aristeromycin.

scientific article published on 31 August 2016

Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme

scientific article published on 20 July 2017

Functional Characterization of 3-Aminobenzoic Acid Adenylation Enzyme PctU and UDP-N-Acetyl-d-Glucosamine: 3-Aminobenzoyl-ACP Glycosyltransferase PctL in Pactamycin Biosynthesis

scientific article published on 20 August 2019

Functional analysis of type 1 isopentenyl diphosphate isomerase from Halobacterium sp. NRC-1.

scientific article published on 7 October 2007

Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin

scientific article published on 18 November 2019

Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

scientific article published on 02 April 2019

Generation of incednine derivatives by mutasynthesis

scientific article published on 04 June 2020

Genome Mining Reveals Two Novel Bacterial Sesquiterpene Cyclases: (−)-Germacradien-4-ol and (−)-epi-α-Bisabolol Synthases from Streptomyces citricolor

scientific article published on 01 October 2011

Genome Mining of the Hitachimycin Biosynthetic Gene Cluster: Involvement of a Phenylalanine-2,3-aminomutase in Biosynthesis

article

Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase ⬇️

article

Giant vesicles from 72-membered macrocyclic archaeal phospholipid analogues: initiation of vesicle formation by molecular recognition between membrane components

scientific article published on 01 September 2000

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.

scientific article published on 13 June 2017

Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3.

scientific article published on 7 August 2013

Importance of specific hydrogen-bond donor-acceptor interactions for the key carbocycle-forming reaction catalyzed by 2-deoxy-scyllo-inosose synthase in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics.

scientific article

Inhibition of type 2 isopentenyl diphosphate isomerase from Methanocaldococcus jannaschii by a mechanism-based inhibitor of type 1 isopentenyl diphosphate isomerase.

scientific article

Inhibition of vitamin D3-induced cell differentiation by interferon-gamma in HL-60 cells determined by a nitroblue tetrazolium reduction test

scientific article published on 01 November 1995

Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids

scientific article

Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.

scientific article

Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin

scientific article

Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis.

scientific article published on 9 September 2016

Mechanistic and stereochemical studies on Ferrier reaction by means of chirally deuterated glucose

Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis

scientific article

NAD+ -Dependent Dehydrogenase PctP and Pyridoxal 5'-Phosphate Dependent Aminotransferase PctC Catalyze the First Postglycosylation Modification of the Sugar Intermediate in Pactamycin Biosynthesis

scientific article published on 17 November 2017

Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host. ⬇️

scientific article published on 21 January 2015

Overproduction and substrate specificity of 3-isopropylmalate dehydrogenase from Thiobacillus ferrooxidans

scientific article published on 01 February 1998

Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis inStreptomyces graminofaciensA-8890

scientific article published on 08 January 2016

Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

scientific article published on 01 November 2018

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

scientific article published on 21 May 2019

Role of glutamate 243 in the active site of 2-deoxy-scyllo-inosose synthase from Bacillus circulans

scientific article published on 10 October 2006

Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis.

scientific article

Stereochemistry in the Reaction of the myo-Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis

scientific article published on 13 December 2019

Stereochemistry of reduction in digeranylgeranylglycerophospholipid reductase involved in the biosynthesis of archaeal membrane lipids from Thermoplasma acidophilum

scientific article published on 01 February 2007

Stereostructure of a novel cytotoxic 18-membered macrolactone antibiotic FD-891

scientific article published on 01 October 2002

Structural Analysis of the Glycine Oxidase Homologue CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis

scientific article published on 04 June 2019

Structural Basis of Protein–Protein Interactions between a trans-Acting Acyltransferase and Acyl Carrier Protein in Polyketide Disorazole Biosynthesis

scientific article published on 13 June 2018

Structural Diversity of the Membrane Core Lipids of Extreme Halophiles

scientific article published on 01 January 1998

Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an α,β-unsaturated thioester.

scientific article published on 18 May 2017

Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+

scientific article

Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor

scientific article

Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

scientific article published on February 2016

Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis.

scientific article published on 4 September 2017

Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin

scientific article published on 28 March 2007

Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase.

scientific article

Substrate specificity of Chondroitinase ABC I based on analyses of biochemical reactions and crystal structures in complex with disaccharides

scientific article published on 01 December 2021

Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3'-deoxygenation of aminoglycoside antibiotics.

scientific article

Synthesis and biological activity of (22E,25R)- and (22,25S)-22-dehydro- 1 alpha,25-dihydroxy-26-methylvitamin D3

scientific article published on 01 May 1990

The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.

scientific article published on 22 September 2014

The crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substrates

scientific article

The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells

scientific article published on 10 July 2009

Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway.

scientific article

Total Synthesis of Archaeal 36-Membered Macrocyclic Diether Lipid

scientific article published on 01 April 1997

Unique Solvent-Dependent Atropisomerism of a Novel Cytotoxic Naphthoxanthene Antibiotic FD-594

scientific article published on 01 July 1999

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