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List of works by Jonathan J Keats

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis

scientific article published in January 2019

An integrated framework for reporting clinically relevant biomarkers from paired tumor/normal genomic and transcriptomic sequencing data in support of clinical trials in personalized medicine

scientific article

Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.

scientific article

Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma

scientific article published on 17 March 2021

Clonal competition with alternating dominance in multiple myeloma.

scientific article

Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

scientific article published on 12 June 2020

Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases.

scientific article published on 22 November 2017

Daratumumab induces CD38 internalization and impairs myeloma cell adhesion

scientific article published on 23 July 2018

Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting

scientific article published on 16 April 2020

Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution.

scientific article published on 14 June 2007

Early Relapse Risk in Newly Diagnosed Multiple Myeloma Patients Characterized by Next-Generation Sequencing

scientific article published on 02 July 2020

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

scientific article published on 09 September 2021

Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma

scientific article

Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalities

scientific article published on 3 February 2012

High somatic mutation and neoantigen burden are correlated with decreased progression-free survival in multiple myeloma

scientific article published on 22 September 2017

High-resolution genomic analysis in Waldenström's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomas

scientific article (publication date: March 2009)

Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia

scientific article (publication date: 15 April 2009)

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

scientific article published on 08 June 2018

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

scientific article published on 03 October 2002

Initial genome sequencing and analysis of multiple myeloma

scientific article

Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma.

scientific article published on 23 June 2017

Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma

scientific article published on 29 March 2018

MYC dysregulation in the progression of multiple myeloma

scientific article published on 22 August 2019

Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma Cells ⬇️

scientific article published on December 22, 2011

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

scientific article published on 23 April 2019

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

scientific article

Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications

scientific article published on 17 November 2021

Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.

scientific article

RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.

scientific article published in April 2017

RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5 ⬇️

scientific article published on February 2, 2011

Spontaneous remission in a patient with t(4;14) translocation multiple myeloma

scientific article published on 05 October 2009

Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma.

scientific article published on November 2006

The CCND1 c.870G risk allele is enriched in individuals of African ancestry with plasma cell dyscrasias

scientific article published on 16 March 2020

The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

scientific article published on 14 July 2020

The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma.

scientific article published on 10 December 2007

Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination

scientific article published on 08 October 2019

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

scientific article published in October 2017

VIII International Myeloma Workshop, Banff Springs Hotel, Banff, Alberta, Canada, 4–8 May 2001 ⬇️

scientific article published on September 1, 2001

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

scientific article

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

scientific article published in January 2014

Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma

scientific article published on 12 October 2015

Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma

scientific article published on September 2013

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