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List of works by Nicholas J Clemons

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

scientific article published on 14 December 2020

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

scientific article published on 17 July 2015

Advances in understanding the pathogenesis of Barrett's esophagus

scientific article

Barrett's esophagus: cancer and molecular biology.

scientific article published on October 2013

Bridging the molecular divide: Alcohol-induced downregulation of PAX9 and tumour development.

scientific article published on 18 January 2018

Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma

scientific article

Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.

scientific article published on January 2014

Correction: Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

scientific article published on 18 March 2020

Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced DNA damage ⬇️

scientific article published on 01 May 2022

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

scientific article published in 2022

Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

scientific article published on 04 November 2019

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma

scientific article published on 01 August 2020

Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.

scientific article

Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells.

scientific article

Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.

scientific article published on 15 September 2004

Inhibiting system xC- and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers.

scientific article published on 5 July 2017

Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

scientific article published on 28 March 2017

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

scientific article published on 18 February 2015

Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer.

scientific article published on 28 June 2013

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

scientific article published on 15 July 2021

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

scientific article published on 15 November 2010

Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma.

scientific article published on 27 June 2010

Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis

scientific article

Preclinical models for the study of Barrett's carcinogenesis

scientific article published on 05 July 2018

Preclinical models of esophageal adenocarcinoma for drug development

scientific article published on December 2016

Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction

scientific article

Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.

scientific article published on 11 October 2012

Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

scientific article

TGF-beta signaling and its targeted therapy in gastrointestinal cancers

scientific article published on 01 September 2018

TRAIL-induced apoptosis is enhanced by heat shock protein 70 expression

scientific article

The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis

scientific article

Translational research on Barrett's esophagus.

scientific article published in September 2014

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