List of works - Alessandro Pini

A branched peptide mimotope of the nicotinic receptor binding site is a potent synthetic antidote against the snake neurotoxin alpha-bungarotoxin

scientific article published on 01 August 2002

A novel phage-library-selected peptide inhibits human TNF-α binding to its receptors.

scientific article

A novel tetrabranched antimicrobial peptide that neutralizes bacterial lipopolysaccharide and prevents septic shock in vivo.

scientific article published on 16 November 2009

An antimicrobial molecule mitigates signs of sepsis in vivo and eradicates infections from lung tissue

scientific article published on 20 November 2019

Antimicrobial activity of novel dendrimeric peptides obtained by phage display selection and rational modification

scientific article

Antimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles

scientific article published on 05 June 2019

Bioactive peptides from libraries.

scientific article

Biochemical filtering of a protein-protein docking simulation identifies the structure of a complex between a recombinant antibody fragment and alpha-bungarotoxin

scientific article

Branched peptides as therapeutics

scientific article

Characterization of the branched antimicrobial peptide M6 by analyzing its mechanism of action and in vivo toxicity.

scientific article

Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate

scientific article published on 6 July 2017

D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions

scientific article published on 11 July 2015

Design and in vitro evaluation of branched peptide conjugates: turning nonspecific cytotoxic drugs into tumor-selective agents.

scientific article published in April 2010

Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel.

scientific article

Diagnostics of myasthenic syndromes: detection of anti-AChR and anti-MuSK antibodies

scientific article published in October 2017

Efficacy and toxicity of the antimicrobial peptide M33 produced with different counter-ions

scientific article published on 8 October 2011

Esculentin(1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas aeruginosa.

scientific article

Esculentin-1a-Derived Peptides Promote Clearance of Pseudomonas aeruginosa Internalized in Bronchial Cells of Cystic Fibrosis Patients and Lung Cell Migration: Biochemical Properties and a Plausible Mode of Action

scientific article published on 26 September 2016

Hierarchical affinity maturation of a phage library derived antibody for the selective removal of cytomegalovirus from plasma.

scientific article published on August 1997

Immunomodulatory and Anti-inflammatory Activity in Vitro and in Vivo of a Novel Antimicrobial Candidate

scientific article published on 07 October 2016

In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate

scientific article published on 12 May 2016

Insights into the role of sulfated glycans in cancer cell adhesion and migration through use of branched peptide probe

scientific article

Investigations into the killing activity of an antimicrobial peptide active against extensively antibiotic-resistant K. pneumon iae and P. aeruginosa.

scientific article published on 2 June 2017

Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens

scientific article

Mimotopes of the nicotinic receptor binding site selected by a combinatorial peptide library.

scientific article published in June 2001

Models of In-Vivo Bacterial Infections for the Development of Antimicrobial Peptide-based Drugs

scientific article

Molecular basis of branched peptides resistance to enzyme proteolysis

scientific article published on 01 March 2007

Near-infrared quantum dots labelled with a tumor selective tetrabranched peptide for in vivo imaging.

scientific article published on 3 March 2018

Neurotensin branched peptide as a tumor-targeting agent for human bladder cancer.

scientific article published on 23 April 2015

Oligo-branched peptides for tumor targeting: from magic bullets to magic forks

scientific article published on 01 February 2009

Phage display and colony filter screening for high-throughput selection of antibody libraries.

scientific article

Phage display of antibody fragments.

scientific article

Site-specific pegylation of an antimicrobial peptide increases resistance to Pseudomonas aeruginosa elastase

scientific article published on 08 February 2014

Solubility improvement of an anthrax toxin peptide inhibitor by rational amino acid randomization.

scientific article

Stable peptide inhibitors prevent binding of lethal and oedema factors to protective antigen and neutralize anthrax toxin in vivo

scientific article

Strategies for the construction and use of peptide and antibody libraries displayed on phages

scientific article

Synergistic activity profile of an antimicrobial peptide against multidrug-resistant and extensively drug-resistant strains of Gram-negative bacterial pathogens

scientific article published on 8 February 2017

Synthesis and biological activity of stable branched neurotensin peptides for tumor targeting

scientific article published on 31 August 2007

Target-selective drug delivery through liposomes labeled with oligobranched neurotensin peptides

scientific article published on 02 March 2011

The GAG-specific branched peptide NT4 reduces angiogenesis and invasiveness of tumor cells.

scientific article

The development of antimicrobial peptides as new antibacterial drugs.

scientific article published on December 2013

The proteome speciation of an immortalized cystic fibrosis cell line: New perspectives on the pathophysiology of the disease.

scientific article published on 29 September 2017

Tumor imaging with tetrabranched neurotensin.

scientific article published in January 2009

Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug

scientific article

Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity

scientific article published on 18 September 2019

List of works by Alessandro Pini

A branched peptide mimotope of the nicotinic receptor binding site is a potent synthetic antidote against the snake neurotoxin alpha-bungarotoxin

A novel phage-library-selected peptide inhibits human TNF-α binding to its receptors.

A novel tetrabranched antimicrobial peptide that neutralizes bacterial lipopolysaccharide and prevents septic shock in vivo.

An antimicrobial molecule mitigates signs of sepsis in vivo and eradicates infections from lung tissue

Antimicrobial activity of novel dendrimeric peptides obtained by phage display selection and rational modification

Antimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles

Bioactive peptides from libraries.

Biochemical filtering of a protein-protein docking simulation identifies the structure of a complex between a recombinant antibody fragment and alpha-bungarotoxin

Branched peptides as therapeutics

Characterization of the branched antimicrobial peptide M6 by analyzing its mechanism of action and in vivo toxicity.

Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate

D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions

Design and in vitro evaluation of branched peptide conjugates: turning nonspecific cytotoxic drugs into tumor-selective agents.

Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel.

Diagnostics of myasthenic syndromes: detection of anti-AChR and anti-MuSK antibodies

Efficacy and toxicity of the antimicrobial peptide M33 produced with different counter-ions

Esculentin(1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas aeruginosa.

Esculentin-1a-Derived Peptides Promote Clearance of Pseudomonas aeruginosa Internalized in Bronchial Cells of Cystic Fibrosis Patients and Lung Cell Migration: Biochemical Properties and a Plausible Mode of Action

Hierarchical affinity maturation of a phage library derived antibody for the selective removal of cytomegalovirus from plasma.

Immunomodulatory and Anti-inflammatory Activity in Vitro and in Vivo of a Novel Antimicrobial Candidate

In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate

Insights into the role of sulfated glycans in cancer cell adhesion and migration through use of branched peptide probe

Investigations into the killing activity of an antimicrobial peptide active against extensively antibiotic-resistant K. pneumon iae and P. aeruginosa.

Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens

Mimotopes of the nicotinic receptor binding site selected by a combinatorial peptide library.

Models of In-Vivo Bacterial Infections for the Development of Antimicrobial Peptide-based Drugs

Molecular basis of branched peptides resistance to enzyme proteolysis

Near-infrared quantum dots labelled with a tumor selective tetrabranched peptide for in vivo imaging.

Neurotensin branched peptide as a tumor-targeting agent for human bladder cancer.

Oligo-branched peptides for tumor targeting: from magic bullets to magic forks

Phage display and colony filter screening for high-throughput selection of antibody libraries.

Phage display of antibody fragments.

Site-specific pegylation of an antimicrobial peptide increases resistance to Pseudomonas aeruginosa elastase

Solubility improvement of an anthrax toxin peptide inhibitor by rational amino acid randomization.

Stable peptide inhibitors prevent binding of lethal and oedema factors to protective antigen and neutralize anthrax toxin in vivo

Strategies for the construction and use of peptide and antibody libraries displayed on phages

Synergistic activity profile of an antimicrobial peptide against multidrug-resistant and extensively drug-resistant strains of Gram-negative bacterial pathogens

Synthesis and biological activity of stable branched neurotensin peptides for tumor targeting

Target-selective drug delivery through liposomes labeled with oligobranched neurotensin peptides

The GAG-specific branched peptide NT4 reduces angiogenesis and invasiveness of tumor cells.

The development of antimicrobial peptides as new antibacterial drugs.

The proteome speciation of an immortalized cystic fibrosis cell line: New perspectives on the pathophysiology of the disease.

Tumor imaging with tetrabranched neurotensin.

Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug

Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity