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List of works by Sam Alsford

A fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma brucei

scientific article published on 01 October 1996

A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.

scientific article published on 4 January 2007

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

scientific article

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

scientific article (publication date: May 2014)

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.

scientific article published on 31 August 2012

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

scientific article published on 25 July 2019

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.

scientific article published on 12 September 2016

Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.

scientific article published on 23 November 2015

Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA

scientific article

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

scientific article

DNA breaks as triggers for antigenic variation in African trypanosomes

scientific article published on 08 June 2009

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1.

scientific article published on 18 January 2018

Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest

scientific article published on 23 January 2007

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

scientific article

Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.

scientific article published on 29 May 2012

Genetic dissection of drug resistance in trypanosomes

scientific article

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

scientific article published on 11 December 2014

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6 ⬇️

scientific article published on November 18, 2010

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

scientific article

High-throughput decoding of antitrypanosomal drug efficacy and resistance

scientific article published on 25 January 2012

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

scientific article

Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis.

scientific article

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

scientific article published on 26 November 2018

Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes

scientific article

Multiplex analysis of RNA interference defects in Trypanosoma brucei

scientific article published on January 2005

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions

scientific article (publication date: 2012)

Nicotinic acetylcholine receptors on the surface of the blood fluke Schistosoma

scientific article published on 01 April 1995

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.

scientific article published on 5 July 2017

RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei.

scientific article published on 21 January 2007

Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.

scientific article published on 17 April 2013

Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms

scientific article published on 01 August 1998

Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei

scientific article published on 7 June 2008

Subverting lysosomal function in Trypanosoma brucei

scientific article published on August 2015

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

scientific article published on 6 September 2005

Trypanosomatid histones.

scientific article published in July 2004

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.

scientific article published on 9 July 2008

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

scientific article published on 25 May 2016

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