List of works - Timo Rieg

A High-throughput method for measurement of glomerular filtration rate in conscious mice

scientific article published on 10 May 2013

A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.

scientific article

ATP and adenosine in the local regulation of water transport and homeostasis by the kidney

scientific article

Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

scientific article

Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus

scientific article published on 10 March 2009

Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite

scientific article published on 25 October 2006

Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla

scientific article

Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin–Induced Diarrhea

scientific article published on 01 October 2019

Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC

scientific article

Adenylyl cyclase 6 is required for maintaining acid–base homeostasis

article

Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha

scientific article published on March 2007

Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models

scientific article published on 7 November 2015

Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function

scientific article published on 13 May 2009

Body mass-specific Na+, K+-ATPase activity in the medullary thick ascending limb - implications for species-dependent urine concentrating mechanisms

scientific article published on 3 January 2018

Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3

scientific article

Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling

scientific article

Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney.

scientific article

Connecting type A intercalated cell metabolic state to V-ATPase function: phosphorylation does matter!

scientific article published on 31 July 2013

Contribution of NHE3 and dietary phosphate to lithium pharmacokinetics

scientific article published on 09 November 2018

Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.

scientific article

Development of SGLT1 and SGLT2 inhibitors

article

Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone.

scientific article

Different actions of protein kinase C isoforms alpha and epsilon on gastric acid secretion

scientific article published on July 2002

Functional consequences at the single-nephron level of the lack of adenosine A1 receptors and tubuloglomerular feedback in mice

scientific article published on 6 February 2004

Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney

scientific article

Genetic deletion of connexin 37 causes polyuria and polydipsia

scientific article published on 17 December 2020

Holding Tight and Staying True: Generation of a new tamoxifen-inducible, principal cell-specific mouse

scientific article published on 10 January 2018

Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia.

scientific article

Kidney function in mice: thiobutabarbital versus alpha-chloralose anesthesia.

scientific article published on 30 September 2004

Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus

scientific article published on 14 November 2012

Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption.

scientific article published on 15 June 2007

Multiple organic anion transporters contribute to net renal excretion of uric acid

scientific article

NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification

scientific article published in 2022

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion

scientific article published on 28 November 2011

Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice

scientific article

Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3.

scientific article

Organic anion transporter 3 contributes to the regulation of blood pressure

scientific article published on 28 May 2008

Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt

scientific article published on 18 June 2008

Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.

scientific article published on 23 January 2008

P2Y receptors and kidney function.

scientific article

P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion

scientific article

P2Y₂ receptor activation decreases blood pressure via intermediate conductance potassium channels and connexin 37

scientific article published on 8 January 2015

Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone

scientific article

Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function

scientific article published on 13 August 2019

Purinergic inhibition of ENaC produces aldosterone escape

scientific article

Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter

scientific article published on 28 June 2019

Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice

scientific article

Regulation of nephron water and electrolyte transport by adenylyl cyclases

scientific article

Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system

scientific article

Renal phosphate wasting in the absence of adenylyl cyclase 6

scientific article

Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade

scientific article

Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis

scientific article

Reply to "Reduced NHE3 activity results in congenital diarrhea and can predispose to inflammatory bowel disease".

scientific article published in March 2017

Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine

scientific article published on 8 December 2004

SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.

scientific article

SGLT2 mediates glucose reabsorption in the early proximal tubule.

scientific article

Sodium-glucose cotransport

scientific article published on September 2015

Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1.

scientific article published on 17 February 2006

The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion

scientific article published on 20 June 2007

Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity.

scientific article published on 21 January 2009

Unravelling a role for KCNQ1 in K+ recycling and gastric acid secretion

scientific article published in September 2009

Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors

scientific article published on 16 January 2008

What does sodium-glucose co-transporter 1 inhibition add: Prospects for dual inhibition

scientific article published on 01 April 2019

List of works by Timo Rieg

A High-throughput method for measurement of glomerular filtration rate in conscious mice

A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.

ATP and adenosine in the local regulation of water transport and homeostasis by the kidney

Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus

Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite

Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla

Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin–Induced Diarrhea

Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC

Adenylyl cyclase 6 is required for maintaining acid–base homeostasis

Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha

Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models

Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function

Body mass-specific Na+, K+-ATPase activity in the medullary thick ascending limb - implications for species-dependent urine concentrating mechanisms

Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3

Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling

Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney.

Connecting type A intercalated cell metabolic state to V-ATPase function: phosphorylation does matter!

Contribution of NHE3 and dietary phosphate to lithium pharmacokinetics

Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.

Development of SGLT1 and SGLT2 inhibitors

Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone.

Different actions of protein kinase C isoforms alpha and epsilon on gastric acid secretion

Functional consequences at the single-nephron level of the lack of adenosine A1 receptors and tubuloglomerular feedback in mice

Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney

Genetic deletion of connexin 37 causes polyuria and polydipsia

Holding Tight and Staying True: Generation of a new tamoxifen-inducible, principal cell-specific mouse

Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia.

Kidney function in mice: thiobutabarbital versus alpha-chloralose anesthesia.

Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus

Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption.

Multiple organic anion transporters contribute to net renal excretion of uric acid

NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion

Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice

Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3.

Organic anion transporter 3 contributes to the regulation of blood pressure

Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt

Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.

P2Y receptors and kidney function.

P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion

P2Y₂ receptor activation decreases blood pressure via intermediate conductance potassium channels and connexin 37

Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone

Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function

Purinergic inhibition of ENaC produces aldosterone escape

Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter

Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice

Regulation of nephron water and electrolyte transport by adenylyl cyclases

Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system

Renal phosphate wasting in the absence of adenylyl cyclase 6

Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade

Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis

Reply to "Reduced NHE3 activity results in congenital diarrhea and can predispose to inflammatory bowel disease".

Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine

SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.

SGLT2 mediates glucose reabsorption in the early proximal tubule.

Sodium-glucose cotransport

Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1.

The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion

Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity.

Unravelling a role for KCNQ1 in K+ recycling and gastric acid secretion

Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors

What does sodium-glucose co-transporter 1 inhibition add: Prospects for dual inhibition