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List of works by Caroline C Klaver

A 3-year follow-up study of atropine treatment for progressive myopia in Europeans

scientific article published on 21 September 2020

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

scientific article

A comparative study of atypical and melanocytic naevi on the tropical island Cura??ao and in The Netherlands ⬇️

scientific article published on June 1, 1995

A genetic epidemiologic study of candidate genes involved in the optic nerve head morphology

scientific article

A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.

scientific article

A genome-wide association study of optic disc parameters

scientific article

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

scientific article published on 21 December 2015

A method of drusen measurement based on the geometry of fundus reflectance

scientific article

Accuracy of Four Commonly Used Color Vision Tests in the Identification of Cone Disorders

scientific article published on 01 April 2013

Age-Specific Prevalence and Causes of Blindness and Visual Impairment in an Older Population

scientific article published on 01 May 1998

Age-related maculopathy: its genetic basis.

scientific article

Antiplatelet and anticoagulant drugs do not affect visual outcome in neovascular age-related macular degeneration in the BRAMD trial.

scientific article published on 9 January 2018

Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

scientific article published on 02 July 2013

Association of Axial Length With Risk of Uncorrectable Visual Impairment for Europeans With Myopia.

scientific article

Association of Genetic Variants with Primary Open-Angle Glaucoma among Individuals with African Ancestry

scientific article published on 01 November 2019

Association of Smoking and CFH and ARMS2 Risk Variants With Younger Age at Onset of Neovascular Age-Related Macular Degeneration.

scientific article published on May 2015

Association of cognitive functioning with retinal nerve fiber layer thickness.

scientific article

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

scientific article published in Nature Communications

Axial length growth and the risk of developing myopia in European children.

scientific article published on 19 December 2017

Causes and consequences of inherited cone disorders.

scientific article published on 22 May 2014

Characterizing the Impact of Off-Axis Scan Acquisition on the Reproducibility of Total Retinal Thickness Measurements in SDOCT Volumes.

scientific article published on 31 July 2015

Clinical Course, Genetic Etiology, and Visual Outcome in Cone and Cone–Rod Dystrophy ⬇️

scientific article published on January 20, 2012

Clinical Implications of Old and New Genes for Open-Angle Glaucoma

article

Clinical course of cone dystrophy caused by mutations in the RPGR gene

scientific article

Common genetic determinants of intraocular pressure and primary open-angle glaucoma

scientific article

Common genetic variants associated with open-angle glaucoma

scientific article published on 22 March 2011

Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract

scientific article published on 11 December 2020

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration

scientific article

Complement component C3 and risk of age-related macular degeneration

scientific article published on 24 January 2009

Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration

scientific article

Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans

scientific article

Concurrent Loss of Chromosome Arm 1p and Chromosome 3 Predicts a Decreased Disease-Free Survival in Uveal Melanoma Patients

scientific article published on 01 July 2005

Cone-rod dystrophy can be a manifestation of Danon disease

scientific article published in May 2012

Course of Visual Decline in Relation to the Best1 Genotype in Vitelliform Macular Dystrophy

scientific article published on 09 April 2010

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

scientific article

Design of a frailty index among community living middle-aged and older people: The Rotterdam study

scientific article published on 12 December 2016

Diagnostic exome sequencing in 266 Dutch patients with visual impairment.

scientific article

Differences in clinical presentation of primary open-angle glaucoma between African and European populations

scientific article published on 08 February 2021

Distribution of Central Corneal Thickness and Its Association With Intraocular Pressure: The Rotterdam Study ⬇️

scientific article published on June 1, 1997

Duke-Elder's Views on Prognosis, Prophylaxis, and Treatment of Myopia: Way Ahead of His Time.

scientific article

Effectiveness study of atropine for progressive myopia in Europeans.

scientific article

Epidemiology of age-related maculopathy.

scientific article published on January 1995

Epidemiology of age-related maculopathy: a review

scientific article published on January 1, 2003

Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

article

Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1.

scientific article

Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies

scientific article published on 12 September 2011

Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age.

scientific article published on 22 October 2013

Familial aggregation of age-related maculopathy

scientific article published on 01 December 1997

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report.

scientific article published on 20 January 2017

Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration ⬇️

scientific article published on July 1, 1998

Genetic Risk of Primary Open-angle Glaucoma

scientific article published on 01 December 1998

Genetic Testing and Clinical Characterization of Patients with Cone-Rod Dystrophy ⬇️

scientific article published on December 1, 2010

Genetic architecture of open angle glaucoma and related determinants

scientific article published on 7 November 2010

Genetic contributions to glaucoma: heritability of intraocular pressure, retinal nerve fiber layer thickness, and optic disc morphology

scientific article

Genetic etiology and clinical consequences of complete and incomplete achromatopsia.

scientific article published on 9 July 2009

Genetic risk of rhegmatogenous retinal detachment: a familial aggregation study.

scientific article

Genetic variants in microRNAs and their binding sites within gene 3'UTRs associate with susceptibility to age-related macular degeneration.

scientific article published on 10 April 2017

Genetics of macular dystrophies and implications for age-related macular degeneration.

scientific article

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

scientific article

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

scientific article published on 06 January 2013

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

scientific article published on 28 May 2018

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

scientific article published on 19 March 2020

Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area

article

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium

scientific article

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

scientific article

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci

scientific article

Genotypic and Phenotypic Characteristics of CRB1-Associated Retinal Dystrophies: A Long-Term Follow-up Study

scientific article published on 13 March 2017

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes

scientific journal article

Heterogeneity of the genetic risk in age-related macular disease

scientific article published on 01 March 2005

Heterozygous Deep-Intronic Variants and Deletions inABCA4in Persons with Retinal Dystrophies and One ExonicABCA4Variant

Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma

scientific article

High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study

scientific article published on 11 January 2013

Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders.

scientific article

IMPG2-associated retinitis pigmentosa displays relatively early macular involvement.

scientific article published on 29 May 2014

Identification of a candidate gene for astigmatism

scientific journal article

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

scientific article published on 15 September 2013

Incidence of glaucomatous visual field loss after two decades of follow-up: the Rotterdam Study

scientific article

Is age-related maculopathy associated with Alzheimer's Disease? The Rotterdam Study.

scientific article published in November 1999

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

scientific article

Long-term follow-up in enhanced s-cone syndrome

scientific article

Long-term longitudinal changes in axial length in the Caucasian myopic and hyperopic population with a phakic intraocular lens

scientific article published on 29 October 2020

Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

scientific article published on 03 June 2021

Low serum vitamin D is associated with axial length and risk of myopia in young children

scientific article published on 08 March 2016

Macrophages feel their age in macular degeneration.

scientific article published on November 2007

Maternal uniparental isodisomy of chromosome 6 reveals a TULP1 mutation as a novel cause of cone dysfunction.

scientific article published on 15 March 2013

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

scientific article published on 30 March 2020

Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology

scientific article published on 28 January 2015

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

scientific article published on 29 March 2016

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

scientific article

Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error

scientific article

Method for segmentation of the layers in the outer retina.

scientific article published on August 2015

Multi-trait genome-wide association study identifies new loci associated with optic disc parameters

scientific article published on 27 November 2019

Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration

scientific article published on 17 March 2012

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

scientific article published on 20 January 2020

Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa.

scientific article

Mutations in MFSD8, encoding a lysosomal membrane protein, are associated with nonsyndromic autosomal recessive macular dystrophy

scientific article published on 13 September 2014

Myopia management in the Netherlands

scientific article published on 01 March 2020

Myopia, a growing health problem

scientific article

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error

scientific article

Novel Genetic Loci Associated With Retinal Microvascular Diameter

scientific article published on 13 November 2015

Optimisation of an automated drusen-quantifying software for the analysis of drusen distribution in patients with age-related macular degeneration ⬇️

scientific article published on January 11, 2013

Osteoporotic vertebral fractures during pregnancy: be aware of a potential underlying genetic cause

scientific article published on 13 January 2014

Patient-reported utilities in bilateral visual impairment from amblyopia and age-related macular degeneration.

scientific article

Phenotypic features of patients with NR2E3 mutations.

scientific article published in January 2009

Pigmentary Irregularities and Optic Disc Edema After Heart Transplantation

scientific article published on 01 October 1995

Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.

scientific article

Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium

scientific article published on 10 October 2013

Predictive Value of Multiple Genetic Testing for Age-Related Macular Degeneration

scientific article published on 01 September 2007

Prevalence of Amblyopia and Refractive Errors in an Unscreened Population of Children

scientific article published on 01 November 2012

Progressive loss of cones in achromatopsia: an imaging study using spectral-domain optical coherence tomography.

scientific article published on 23 June 2010

Re: Sundaram et al.: Retinal structure and function in achromatopsia: implications for gene therapy (Ophthalmology 2014;121:234-45).

scientific article published in May 2014

Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa.

scientific article published on June 2006

Reducing the Genetic Risk of Age-Related Macular Degeneration With Dietary Antioxidants, Zinc, and ω-3 Fatty Acids

scientific article published on 01 June 2011

Retinal microvasculature and cardiovascular health in childhood

scientific article

Retinal neurodegeneration and brain MRI markers: the Rotterdam Study

scientific article published on 14 September 2017

Retinal phenotypes in patients homozygous for the G1961E mutation in the ABCA4 gene.

scientific article

Retinal vascular calibers associate differentially with cerebral gray matter and white matter atrophy

scientific article

Risk Alleles in CFH and ARMS2 Are Independently Associated with Systemic Complement Activation in Age-related Macular Degeneration

scientific article published on 30 November 2011

Risk factors for age-related macular degeneration: Pooled findings from three continents.

scientific article published in April 2001

Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization

scientific article published on 07 January 2020

Seven new loci associated with age-related macular degeneration

scientific article

Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

scientific article

Smoking Is Also Associated With Age-Related Macular Degeneration in Persons Aged 85 Years and Older: The Rotterdam Study

scientific article published on 01 July 1997

Subclinical vascular disease and the risk of parkinsonism: The Rotterdam Study

scientific article published on 28 June 2017

Symptoms and findings predictive for the development of new retinal breaks

scientific article published in April 2005

The Generation R Study: Biobank update 2015.

scientific article published on 21 December 2014

The Generation R Study: design and cohort update 2017

scientific article published on 09 January 2017

The RD5000 database: facilitating clinical, genetic, and therapeutic studies on inherited retinal diseases

scientific article (publication date: November 2014)

The Rotterdam Study: 2016 objectives and design update

scientific article

The SERPING1 gene and age-related macular degeneration

scientific article published on September 2009

The SERPING1 gene and age-related macular degeneration

article

The effect of light deprivation in patients with Stargardt disease.

scientific article published on 11 February 2015

The efficacy of microarray screening for autosomal recessive retinitis pigmentosa in routine clinical practice

scientific article published on 28 April 2015

The genetics of age-related macular degeneration.

scientific article

The retinal microcirculation in migraine: The Rotterdam Study.

scientific article published on January 2017

The spectrum of phenotypes caused by variants in the CFH gene.

scientific article

Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene

scientific article

Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene

scientific article

Thyroid function and age-related macular degeneration: a prospective population-based cohort study--the Rotterdam Study

scientific article published on 23 April 2015

Usefulness of Combining Complement Factor H and C-Reactive Protein Genetic Profiles for Predicting Myocardial Infarction (from the Rotterdam Study)

scientific article published on 26 June 2007

Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people

scientific article

Visual Prognosis in USH2A-Associated Retinitis Pigmentosa Is Worse for Patients with Usher Syndrome Type IIa Than for Those with Nonsyndromic Retinitis Pigmentosa

scientific article

Visual consequences of refractive errors in the general population.

scientific article

Whole-Exome Sequencing Identifies Biallelic IDH3A Variants as a Cause of Retinitis Pigmentosa Accompanied by Pseudocoloboma.

scientific article

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