List of works - Haico van Attikum

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.

scientific article published on 19 July 2016

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.

scientific article published on 27 February 2017

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

scientific article

A genetic interaction map centered on cohesin reveals auxiliary factors in sister chromatid cohesion

scientific article published on 16 April 2020

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

scientific article

ATP-dependent chromatin remodeling and DNA double-strand break repair.

scientific article

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice

scientific article published on 29 June 2017

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.

scientific article

Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.

scientific article published on 8 March 2017

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

scientific article published on 13 November 2020

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response Regulators

scientific article published in 2024

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition

scientific article published on 30 September 2015

Chromatin and the DNA damage response: the cancer connection.

scientific article published on 03 July 2011

Close encounters of the RNF8th kind: when chromatin meets DNA repair ⬇️

scientific article published on March 29, 2012

Crosstalk between histone modifications during the DNA damage response.

scientific article

DDB2 promotes chromatin decondensation at UV-induced DNA damage

scientific article published on 9 April 2012

DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance.

scientific article published on October 2017

Dissection of DNA damage responses using multiconditional genetic interaction maps

scientific article

Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.

scientific article

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

scientific article published on 01 March 2021

Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies

scientific article published on 17 June 2021

Functional Analysis of Missense Variants in the Putative Breast Cancer Susceptibility Gene XRCC2.

scientific article

Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2

scientific article published on 22 November 2019

Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription

scientific article published on 07 November 2019

Genome-wide association data reveal a global map of genetic interactions among protein complexes

scientific article

Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription

scientific article

Improved functional overview of protein complexes using inferred epistatic relationships.

scientific article

Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.

scientific article published on August 2002

Insertional mutagenesis in yeasts using T-DNA from Agrobacterium tumefaciens.

scientific article published in April 2002

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

scientific article published on 11 June 2018

Meta-analysis of DNA double-strand break response kinetics

scientific article published on 22 November 2017

Non-homologous end-joining proteins are required for Agrobacterium T-DNA integration

scientific article

NuRD alert! NuRD regulates the DNA damage response

scientific article published on 01 April 2011

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

scientific article

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

scientific article published on 14 August 2019

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.

scientific article

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks

scientific article published on 30 March 2020

PHF6 promotes non-homologous end joining and G2 checkpoint recovery

scientific article published on 29 November 2019

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling

scientific article

Proteomic analysis identifies novel binding partners of BAP1

scientific article published on 30 September 2021

Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair

scientific article (publication date: 17 December 2004)

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining

scientific article published on 20 August 2013

Remodeling and spacing factor 1 (RSF1): a rising star in DNA repair

scientific article published on 01 June 2014

Rewiring of genetic networks in response to DNA damage.

scientific article

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.

scientific article published on 26 February 2015

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

scientific article published on 01 June 2018

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

scientific article published in June 2019

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

scientific article

TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.

scientific article published on 12 March 2018

Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation

scientific article

The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA

scientific article published on July 2003

The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage

scientific article

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80

scientific article published on 15 December 2015

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

scientific article

The histone code at DNA breaks: a guide to repair?

scientific article

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

scientific article

Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks

scientific article published on 04 April 2013

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks

scientific article

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

scientific article

ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

scientific article published in October 2016

Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining

scientific article published on 12 November 2021

List of works by Haico van Attikum

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

A genetic interaction map centered on cohesin reveals auxiliary factors in sister chromatid cohesion

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

ATP-dependent chromatin remodeling and DNA double-strand break repair.

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.

Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response Regulators

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition

Chromatin and the DNA damage response: the cancer connection.

Close encounters of the RNF8th kind: when chromatin meets DNA repair ⬇️

Crosstalk between histone modifications during the DNA damage response.

DDB2 promotes chromatin decondensation at UV-induced DNA damage

DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance.

Dissection of DNA damage responses using multiconditional genetic interaction maps

Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies

Functional Analysis of Missense Variants in the Putative Breast Cancer Susceptibility Gene XRCC2.

Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2

Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription

Genome-wide association data reveal a global map of genetic interactions among protein complexes

Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription

Improved functional overview of protein complexes using inferred epistatic relationships.

Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.

Insertional mutagenesis in yeasts using T-DNA from Agrobacterium tumefaciens.

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

Meta-analysis of DNA double-strand break response kinetics

Non-homologous end-joining proteins are required for Agrobacterium T-DNA integration

NuRD alert! NuRD regulates the DNA damage response

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks

PHF6 promotes non-homologous end joining and G2 checkpoint recovery

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling

Proteomic analysis identifies novel binding partners of BAP1

Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining

Remodeling and spacing factor 1 (RSF1): a rising star in DNA repair

Rewiring of genetic networks in response to DNA damage.

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.

Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation

The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA

The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

The histone code at DNA breaks: a guide to repair?

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining