List of works - Kazuo Takayama

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

scientific article published on 8 December 2012

<i>In vivo</i> gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics

scientific article published on 31 December 2020

A unique view of SARS-COV-2 through the lens of ORF8 protein

scientific article

Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells

scientific article published on October 2010

An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2

scientific article published in 2022

Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria

scientific article

Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria

Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2

Application of perfluoropolyether elastomers in microfluidic drug metabolism assays

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus

Autoimmunity roots of the thrombotic events after COVID-19 vaccination

Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2

Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses such as SARS-CoV-2

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision

scientific article published on 27 November 2013

COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?

scientific article published in 2021

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era

publication published on 07 April 2021

Cell response analysis in SARS-CoV-2 infected bronchial organoids

scientific article published on 30 May 2022

Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance

scientific article published on 27 February 2020

Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

scientific article published on 07 April 2022

Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

scientific article published on 30 November 2017

Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells

Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene.

scientific article published on 6 May 2014

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.

scientific article published on 21 November 2018

Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction

scientific article

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.

scientific article published on 8 November 2011

Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX.

scientific article

Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips

Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function

Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function

scientific article published on 02 December 2021

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research

scientific article published on 18 January 2018

Establishment of MDR1-knockout human induced pluripotent stem cell line

scientific article published on 10 February 2020

Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

scientific article published on 21 November 2019

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening

scientific article published in 2022

Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids

Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection

Expression of coxsackievirus and adenovirus receptor separates hematopoietic and cardiac progenitor cells in fetal liver kinase 1-expressing mesoderm

scientific article published on 11 March 2015

FGF signal is not required for hepatoblast differentiation of human iPS cells

article published in 2019

Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools

Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells

scientific article

Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System

Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine

scientific article published on 01 January 2020

Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction

scientific article published on 19 June 2019

Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy

scientific article published on 12 January 2018

Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

scientific article published on 02 February 2017

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

scientific article

Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening

scientific article published on 26 October 2016

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

scientific article published on 29 May 2012

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.

scientific article

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.

scientific article published on 08 December 2015

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells

scientific article published on 8 September 2017

Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells.

scientific article published on 21 December 2016

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system.

scientific article

Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling.

scientific article published on 24 April 2017

Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B.

scientific article published in February 2018

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection.

scientific article published on 04 April 2017

Implications derived from S-protein variants of SARS-CoV-2 from six continents

scientific article published on 24 September 2021

In Vitro and Animal Models for SARS-CoV-2 research

scientific article published on 30 May 2020

Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression

scientific article published on January 2017

Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices

Introductions to the Community: Early-Career Researchers in the Time of COVID-19

scientific article published on 01 December 2020

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

scientific article published on 16 February 2017

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells.

scientific article published on 18 April 2016

Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes

scientific article published on 03 October 2013

Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology

Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells

scientific article published on 08 April 2019

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells

scientific article

Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin

Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria

scientific article published in 2021

Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin

scientific article published in 2022

Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2

scientific article published in 2021

Optimal human iPS cell culture method for efficient hepatic differentiation

article

Organ-on-a-chip models for elucidating the cellular biology of infectious diseases

Overview of key molecular and pharmacological targets for diabetes and associated diseases

Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution

scientific article

Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies

scientific article published on 01 January 2019

Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies

scientific article published on 01 January 2019

Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

scientific article published on 23 July 2020

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

scientific article published on 13 December 2020

Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas

scientific article

Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells

scientific article published on 12 October 2016

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes.

scientific article

Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis

scientific article

Protective Face Masks: Current Status and Future Trends

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

SARS-CoV-2 research using human pluripotent stem cells and organoids

State-of-the-art in respiratory disease research using respiratory organoids

State-of-the-art liver disease research using liver-on-a-chip

Targeting LIN28: a new hope in prostate cancer theranostics

The Structural Basis of Accelerated Host Cell Entry by SARS-CoV-2<sup>†</sup>

scientific article published on 02 December 2020

The importance of accessory protein variants in the pathogenicity of SARS-CoV-2

scientific article published in 2022

The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19

The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

scientific article

Therapeutic Potential of Cannabinoids on Tumor Microenvironment: A Molecular Switch in Neoplasia Transformation

Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling

scientific article published on 02 January 2020

Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure.

scientific article

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models

scientific article published in 2023

Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

scientific article published on 10 November 2011

Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

scientific article published in 2022

List of works by Kazuo Takayama

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

<i>In vivo</i> gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics

A unique view of SARS-COV-2 through the lens of ORF8 protein

Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells

An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2

Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria

Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria

Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2

Application of perfluoropolyether elastomers in microfluidic drug metabolism assays

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus

Autoimmunity roots of the thrombotic events after COVID-19 vaccination

Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2

Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses such as SARS-CoV-2

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision

COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era

Cell response analysis in SARS-CoV-2 infected bronchial organoids

Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance

Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells

Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene.

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.

Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.

Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX.

Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips

Emergence of Unique SARS-CoV-2 ORF10 Variants and Their Impact on Protein Structure and Function

Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research

Establishment of MDR1-knockout human induced pluripotent stem cell line

Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening

Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids

Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection

Expression of coxsackievirus and adenovirus receptor separates hematopoietic and cardiac progenitor cells in fetal liver kinase 1-expressing mesoderm

FGF signal is not required for hepatoblast differentiation of human iPS cells

Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools

Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells

Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System

Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine

Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction

Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy

Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells

Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells.

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system.

Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling.

Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B.

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection.

Implications derived from S-protein variants of SARS-CoV-2 from six continents

In Vitro and Animal Models for SARS-CoV-2 research

Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression

Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices

Introductions to the Community: Early-Career Researchers in the Time of COVID-19

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells.

Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes

Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology

Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells

Non-Uniform Aspects of SARS-CoV-2 Intraspecies Evolution Reopen Questions on Its Origin

Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria

Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin

Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2

Optimal human iPS cell culture method for efficient hepatic differentiation

Organ-on-a-chip models for elucidating the cellular biology of infectious diseases

Overview of key molecular and pharmacological targets for diabetes and associated diseases