List of works - Josh Lauring

A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting

scientific article published on January 2007

A Polycythemia Vera JAK2 Mutation Masquerading as a Duodenal Cancer Mutation.

scientific article published in December 2016

A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

scientific article published in July 2003

BEAMing sheds light on drug resistance

scientific article published on 7 November 2011

Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma

article

Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA.

scientific article

Detection of cancer DNA in plasma of patients with early-stage breast cancer.

scientific article

ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients

scientific article published on 10 August 2015

Engineering targeted chromosomal amplifications in human breast epithelial cells

scientific article published on 23 June 2015

Evolving Role of the Estrogen Receptor as a Predictive Biomarker: ESR1 Mutational Status and Endocrine Resistance in Breast Cancer

scientific article

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine

scientific article published on January 2013

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

scientific article

GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

scientific article published on 20 October 2017

HER2 missense mutations have distinct effects on oncogenic signaling and migration.

scientific article in 2015

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

scientific article published on 08 August 2019

Human cell line model for cancer-associated KRAS noncoding SNP.

scientific article published on February 2014

Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer.

scientific article published on 3 August 2016

Ki-67 is required for maintenance of cancer stem cells but not cell proliferation.

scientific article published on 28 January 2016

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation

scientific article

Knockin of mutant PIK3CA activates multiple oncogenic pathways

scientific article

MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.

scientific article

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

scientific article

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

scientific article

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

scientific article published on November 2011

PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.

scientific article

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity.

scientific article published on 11 February 2017

Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

scientific article published on 31 May 2017

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

scientific article published on January 2016

Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity

scientific article published on 17 December 2015

Rediagnosis of Lung Cancer as NUT Midline Carcinoma Based on Clues From Tumor Genomic Profiling

scientific article published on 01 May 2018

Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation

scientific article published on 11 April 2013

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

scientific article published on 23 December 2015

TORn in Two Over Breast Cancer Drug Resistance.

scientific article published in January 2013

Tamoxifen-stimulated growth of breast cancer due to p21 loss

scholarly article

The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation

scientific article

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

scientific article

The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer

scientific article

Using cancer genomics to guide clinical decisions.

scientific article

List of works by Josh Lauring

A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting

A Polycythemia Vera JAK2 Mutation Masquerading as a Duodenal Cancer Mutation.

A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

BEAMing sheds light on drug resistance

Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma

Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA.

Detection of cancer DNA in plasma of patients with early-stage breast cancer.

ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients

Engineering targeted chromosomal amplifications in human breast epithelial cells

Evolving Role of the Estrogen Receptor as a Predictive Biomarker: ESR1 Mutational Status and Endocrine Resistance in Breast Cancer

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

HER2 missense mutations have distinct effects on oncogenic signaling and migration.

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation

Human cell line model for cancer-associated KRAS noncoding SNP.

Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer.

Ki-67 is required for maintenance of cancer stem cells but not cell proliferation.

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation

Knockin of mutant PIK3CA activates multiple oncogenic pathways

MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity.

Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity

Rediagnosis of Lung Cancer as NUT Midline Carcinoma Based on Clues From Tumor Genomic Profiling

Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

TORn in Two Over Breast Cancer Drug Resistance.

Tamoxifen-stimulated growth of breast cancer due to p21 loss

The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer

Using cancer genomics to guide clinical decisions.