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List of works by Simon J Clark

Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation

scientific article published on 21 January 2016

Age-dependent changes in heparan sulfate in human Bruch's membrane: implications for age-related macular degeneration

scientific article published on 29 July 2014

Age-related macular degeneration and the role of the complement system.

scientific article published on 21 March 2015

Age-related macular degeneration: genome-wide association studies to translation.

scientific article published on 28 May 2015

Associative and structural properties of the region of complement factor H encompassing the Tyr402His disease-related polymorphism and its interactions with heparin

scientific article

C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation

scientific article

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.

scientific article published on October 2010

Complement factor H in host defense and immune evasion.

scientific article published on 10 December 2016

Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement Regulation

scientific article

Development of a microtiter plate-based glycosaminoglycan array for the investigation of glycosaminoglycan-protein interactions.

scientific article

Enrichment of Bruch's Membrane from Human Donor Eyes

scientific article published on 15 November 2015

Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8.

scientific article published on 5 May 2007

Genetic variants in the complement system predisposing to age-related macular degeneration: a review

scientific article

His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form

scientific article published in Journal of Biological Chemistry

Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration.

scientific article published on 10 October 2014

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

scientific article

Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration

scientific article published on 07 February 2020

Induction of Chemokine Secretion and Monocyte Migration by Human Choroidal Melanocytes in Response to Proinflammatory Cytokines.

scientific article published in December 2016

Loss-of-Function Mutations in the CFH Gene Affecting Alternatively Encoded Factor H-like 1 Protein Cause Dominant Early-Onset Macular Drusen

scientific article published on 21 March 2019

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera

scientific article

Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration.

scientific article published in January 2015

Shiga toxin activates complement and binds factor H: evidence for an active role of complement in hemolytic uremic syndrome

scientific article (publication date: 15 May 2009)

Structural basis for complement factor H linked age-related macular degeneration

scientific article

The eye as a complement dysregulation hotspot.

scientific article

The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells

scientific article published on 9 February 2007

The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation.

scientific article

The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?

scientific article published on 07 December 2013

Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

article

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